Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.1 -- Acting on the CH-OH group of donors → 1.1.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: β-hydroxy-β-methylglutaryl coenzyme A reductase (ambiguous), β-hydroxy-β-methylglutaryl CoA-reductase (ambiguous), 3-hydroxy-3-methylglutaryl coenzyme A reductase (ambiguous), hydroxymethylglutaryl coenzyme A reductase (ambiguous)

Systematic Name: (R)-mevalonate:NAD⁺ oxidoreductase (CoA-acylating)

Unification Links: BRENDA:1.1.1.88, ENZYME:1.1.1.88, IUBMB-ExplorEnz:1.1.1.88

Reaction:
(R)-mevalonate + coenzyme A + 2 NAD⁺ ↔ (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H⁺

Enzymes and Genes:
hydroxymethylglutaryl-CoA reductase: Daci_0287 ( Delftia acidovorans SPH-1 )
hydroxymethylglutaryl-CoA reductase: mvaA ( Pseudomonas sp. mevalonii )

Citations: [Fimognari65]

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References

Fimognari65: Fimognari GM, Rodwell VW (1965). "Substrate-Competitive Inhibition of Bacterial Mevalonate: Nicotinamide-Adenine Dinucleotide Oxidoreductase (acylating CoA)." Biochemistry 4(10);2086-2090.

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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