Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.15 -- Acting on superoxide as acceptor → 1.15.1 -- Acting on superoxide as acceptor

Synonyms: superoxidase dismutase, copper-zinc superoxide dismutase, Cu-Zn superoxide dismutase, ferrisuperoxide dismutase, superoxide dismutase I, superoxide dismutase II, SOD, Cu,Zn-SOD, Mn-SOD, Fe-SOD, SODF, SODS, SOD-1, SOD-2, SOD-3, SOD-4, hemocuprein, erythrocuprein, cytocuprein, cuprein, hepatocuprein

Systematic Name: superoxide:superoxide oxidoreductase

Unification Links: BRENDA:1.15.1.1, ENZYME:1.15.1.1, IUBMB-ExplorEnz:1.15.1.1

Reaction:
2 superoxide + 2 H⁺ → hydrogen peroxide + dioxygen

Enzymes and Genes:
superoxide dismutase (Mn): sodA ( Escherichia coli K-12 substr. MG1655 )
superoxide dismutase (Fe): sodB ( Escherichia coli K-12 substr. MG1655 )
superoxide dismutase (Cu-Zn): sodC ( Escherichia coli K-12 substr. MG1655 )
extracellular superoxide dismutase [Cu-Zn]: SOD3 ( Homo sapiens )
superoxide dismutase [Mn]: SOD2 ( Homo sapiens )
superoxide dismutase [Cu-Zn]: SOD1 ( Homo sapiens )
superoxide dismutase (Fe): AB518002 ( Burkholderia sp. AK-5 )
superoxide dismutase (Mn): MSD1 ( Arabidopsis thaliana col )
superoxide dismutase (Cu-Zn): CSD3 ( Arabidopsis thaliana col )
superoxide dismutase (Cu-Zn): CSD2 ( Arabidopsis thaliana col )
superoxide dismutase (Cu-Zn): CSD1 ( Arabidopsis thaliana col )
superoxide dismutase (Fe): FSD3 ( Arabidopsis thaliana col )
superoxide dismutase (Fe): FSD2 ( Arabidopsis thaliana col )
superoxide dismutase (Fe): FSD1 ( Arabidopsis thaliana col )

Summary:
A metalloprotein; also known as erythrocuprein, hemocuprein or cytocuprein. Enzymes from most eukaryotes contain both copper and zinc; those from mitochondria and most prokaryotes contain manganese or iron.

Citations: [Keele71, Sawada72, Vance72]

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References

Keele71: Keele BB, McCord JM, Fridovich I (1971). "Further characterization of bovine superoxide dismutase and its isolation from bovine heart." J Biol Chem 246(9);2875-80. PMID: 4324341

Sawada72: Sawada Y, Oyama T, Yamazaki I (1972). "Preparation and physicochemical properties of green pea superoxide dismutase." Biochim Biophys Acta 268(2);305-12. PMID: 4337330

Vance72: Vance PG, Keele BB, Rajagopalan KV (1972). "Superoxide dismutase from Streptococcus mutans. Isolation and characterization of two forms of the enzyme." J Biol Chem 247(15);4782-6. PMID: 4559499

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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