Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.2 -- Acting on the aldehyde or oxo group of donors → 1.2.1 -- With NAD(+) or NADP(+) as acceptor

Systematic Name: aryl-aldehyde:NAD⁺ oxidoreductase

Unification Links: BRENDA:1.2.1.29, ENZYME:1.2.1.29, IUBMB-ExplorEnz:1.2.1.29

Reaction:
an aromatic aldehyde + NAD⁺ + H₂O = an aromatic carboxylate + NADH + 2 H⁺

Unofficial Reactions:
syringaldehyde + NAD⁺ + H₂O → syringate + NADH + 2 H⁺,
(-)-dehydrodiconiferyl aldehyde + NAD⁺ + H₂O → (-)-dehydrodiconiferyl acid + NADH + 2 H⁺,
4-nitrobenzaldehyde + NAD⁺ + H₂O → 4-nitrobenzoate + NADH + 2 H⁺,
p-cumic aldehyde + NAD⁺ + H₂O → p-cumate + NADH + 2 H⁺

Summary:
Oxidizes a number of aromatic aldehydes, but not aliphatic aldehydes.

Citations: [Raison66]

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References

Raison66: Raison JK, Henson G, Rienits KG (1966). "The oxidation of gentisaldehyde by nicotinamide-adenine dinucleotide-specific, aromatic aldehyde dehydrogenase from rabbit liver." Biochim Biophys Acta 118(2);285-98. PMID: 4289834

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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