Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.3 -- Acting on the CH-CH group of donors → 1.3.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: lanosterol Δ²⁴-reductase

Systematic Name: sterol:NADP⁺ Δ²⁴-oxidoreductase

Unification Links: BRENDA:1.3.1.72, ENZYME:1.3.1.72, IUBMB-ExplorEnz:1.3.1.72

Reaction:
lathosterol + NADP⁺ ← 5α-cholesta-7,24-dien-3β-ol + NADPH + H⁺

Unofficial Reactions:
cycloartanol + NADP⁺ ← cycloartenol + NADPH + H⁺,
4α-methyl-5α-cholesta-8-en-3-ol + NADP⁺ ← 4α-methyl-zymosterol + NADPH + H⁺,
cholesterol + NADP⁺ ← desmosterol + NADPH + H⁺,
24,25-dihydrolanosterol + NADP⁺ ← lanosterol + NADPH + H⁺,
4,4-dimethyl-5α-cholesta-8-en-3β-ol + NADP⁺ ← 14-demethyllanosterol + NADPH + H⁺

Enzymes and Genes:
Δ²⁴-sterol reductase: DHCR24 ( Homo sapiens )

Summary:
Acts on a range of steroids with a 24(25)-double bond, including lanosterol, desmosterol and zymosterol.

Citations: [Bae97]

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References

Bae97: Bae SH, Paik YK (1997). "Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase." Biochem J 326 ( Pt 2);609-16. PMID: 9291139

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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