Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.3 -- Acting on the CH-CH group of donors → 1.3.99 -- With other, unknown, acceptors

Synonyms: quinaldic acid 4-oxidoreductase

Systematic Name: quinoline-2-carboxylate:acceptor 4-oxidoreductase (hydroxylating)

Unification Links: BRENDA:1.3.99.18, ENZYME:1.3.99.18, IUBMB-ExplorEnz:1.3.99.18

Reaction:
quinaldate + an oxidized electron carrier + H₂O = kynurenate + a reduced two electron carrier + H⁺

Summary:
The enzyme from Pseudomonas sp. AK2 also acts on quinoline-8- carboxylate, whereas that from Serratia marcescens 2CC-1 will oxidize nicotinate; quinaldate is a substrate for both of these enzymes.

2,4,6-Trinitrobenzene sulfonate acid, 1,4-benzoquinone, 1,2- naphthoquinone, nitroblue tetrazolium (NBT), thionine and menadione will serve as an electron acceptor for the former enzyme and ferricyanide for the latter; Meldola blue, iodonitrotetrazolium chloride (INT), phenazine methosulfate (PMS), 2,6- dichlorophenolindophenol (DCPIP) and cytochrome c will act as electron acceptors for both.

Citations: [Sauter93, Fetzner93]

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References

Fetzner93: Fetzner S, Lingens F (1993). "Microbial metabolism of quinoline and related compounds. XVIII. Purification and some properties of the molybdenum- and iron-containing quinaldic acid 4-oxidoreductase from Serratia marcescens 2CC-1." Biol Chem Hoppe Seyler 374(6);363-76. PMID: 8357532

Sauter93: Sauter M, Tshisuaka B, Fetzner S, Lingens F (1993). "Microbial metabolism of quinoline and related compounds. XX. Quinaldic acid 4-oxidoreductase from Pseudomonas sp. AK-2 compared to other procaryotic molybdenum-containing hydroxylases." Biol Chem Hoppe Seyler 374(11);1037-46. PMID: 8292263

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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