Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.4 -- Acting on the CH-NH(2) group of donors → 1.4.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: AlaDH, L-alanine dehydrogenase, NAD-linked alanine dehydrogenase, α-alanine dehydrogenase, NAD-dependent alanine dehydrogenase, alanine oxidoreductase, NADH-dependent alanine dehydrogenase

Systematic Name: L-alanine:NAD⁺ oxidoreductase (deaminating)

Unification Links: BRENDA:1.4.1.1, ENZYME:1.4.1.1, IUBMB-ExplorEnz:1.4.1.1

Reaction:
L-alanine + NAD⁺ + H₂O ↔ pyruvate + ammonium + NADH + H⁺

Enzymes and Genes:
L-alanine/glycine dehydrogenase: ald ( Mycobacterium tuberculosis H37Rv )
alanine dehydrogenase: ald ( Phormidium lapideum )
alanine dehydrogenase: aladh ( Klebsiella aerogenes )
L-alanine dehydrogenase ( Bacillus cereus )
L-alanine dehydrogenase: ald ( Bacillus subtilis )
alanine dehydrogenase: GI:13661832 ( Bilophila wadsworthia RZATAU )

Citations: [Pierard60, Oconnor61, Yoshida65]

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References

Oconnor61: O'connor RJ, Halvorson H (1961). "The substrate specificity of L-alanine dehydrogenase." Biochim Biophys Acta 48;47-55. PMID: 13730044

Pierard60: Pierard A, Wiame JM (1960). "[Properties of L(d)-alanine dehydrogenase]." Biochim Biophys Acta 37;490-502. PMID: 14432812

Yoshida65: Yoshida A, Freese E (1965). "Enzymatic properties of alanine dehydrogenase of Bacillus subtilis." Biochim Biophys Acta 96;248-62. PMID: 14298830

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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