Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.4 -- Acting on the CH-NH(2) group of donors → 1.4.3 -- With oxygen as acceptor

Synonyms: ophio-amino-acid oxidase (ambiguous), L-amino acid:O₂ oxidoreductase, new yellow enzyme

Systematic Name: D-amino-acid:oxygen oxidoreductase (deaminating)

Unification Links: BRENDA:1.4.3.3, ENZYME:1.4.3.3, IUBMB-ExplorEnz:1.4.3.3

Reaction:
a D-amino acid + H₂O + dioxygen → a 2-oxo carboxylate + ammonium + hydrogen peroxide

Unofficial Reactions:
D-lysine + H₂O + dioxygen → 6-amino-2-oxohexanoate + ammonium + hydrogen peroxide,
glycine + H₂O + dioxygen → glyoxylate + ammonium + hydrogen peroxide

Enzymes and Genes:
D-amino acid oxidase: DAO ( Homo sapiens )

Summary:
A flavoprotein (FAD). Wide specificity for D-amino acids. Also acts on glycine.

Citations: [Massey61, Dixon65, Dixon65a]

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References

Dixon65: Dixon M, Kleppe K (1965). "D-amino acid oxidase. 3. Effect of pH." Biochim Biophys Acta 96;383-9. PMID: 14314379

Dixon65a: Dixon M, Kleppe K (1965). "D-amino acid oxidase. I. Dissociation and recombination of the holoenzyme." Biochim Biophys Acta 96;357-67. PMID: 14314378

Massey61: Massey V, Palmer G, Bennett R (1961). "The purification and some properties of D-amino acid oxidase." Biochim Biophys Acta 48;1-9. PMID: 13767909

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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