Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.5 -- Acting on the CH-NH group of donors → 1.5.3 -- With oxygen as acceptor

Synonyms: FAP2

Systematic Name: L-saccharopine:oxygen oxidoreductase (L-glutamate-forming)

Unification Links: BRENDA:1.5.3.18, ENZYME:1.5.3.18, IUBMB-ExplorEnz:1.5.3.18

Reaction:
L-saccharopine + dioxygen + H₂O → (S)-2-amino-6-oxohexanoate + L-glutamate + hydrogen peroxide

Enzymes and Genes:
L-saccharopine oxidase: fap2 ( Schizosaccharomyces pombe )

Summary:
The enzyme is involved in pipecolic acid biosynthesis. A flavoprotein (FAD).

Citations: [Wickwire90, Yoshida04]

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References

Wickwire90: Wickwire BM, Wagner C, Broquist HP (1990). "Pipecolic acid biosynthesis in Rhizoctonia leguminicola. II. Saccharopine oxidase: a unique flavin enzyme involved in pipecolic acid biosynthesis." J Biol Chem 265(25);14748-53. PMID: 2394693

Yoshida04: Yoshida N, Akazawa S, Katsuragi T, Tani Y (2004). "Characterization of two fructosyl-amino acid oxidase homologs of Schizosaccharomyces pombe." J Biosci Bioeng 97(4);278-80. PMID: 16233628

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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