MetaCyc

Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.5 -- Acting on the CH-NH group of donors → 1.5.3 -- With oxygen as acceptor

Synonyms: L-6-hydroxynicotine oxidase, 6-hydroxy-L-nicotine oxidase, 6-hydroxy-L-nicotine:oxygen oxidoreductase, nctB (gene name)

Systematic Name: (S)-6-hydroxynicotine:oxygen oxidoreductase

Unification Links: BRENDA:1.5.3.5, ENZYME:1.5.3.5, IUBMB-ExplorEnz:1.5.3.5

Reaction:
(S)-6-hydroxynicotine + dioxygen + H₂O → 6-hydroxypseudooxynicotine + hydrogen peroxide

Enzymes and Genes:
(S)-6-hydroxynicotine oxidase: nctB ( Shinella sp. HZN7 )
(S)-6-hydroxynicotine oxidase: 6-HLNO ( Paenarthrobacter nicotinovorans )

Summary:
A flavoprotein (FAD). The enzyme, which participates in nicotine degradation, is specific for the (S) isomer of 6-hydroxynicotine. The bacterium Paenarthrobacter nicotinovorans, in which this enzyme was originally discovered, has a different enzyme that catalyses a similar reaction with the less common (R)-isomer (cf. EC 1.5.3.6, (R)-6-hydroxynicotine oxidase).

Citations: [Decker65, Dai68, Schenk98, Qiu14]