Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.8 -- Acting on a sulfur group of donors → 1.8.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: glutathione reductase, glutathione reductase (NADPH), NADPH-glutathione reductase, GSH reductase, GSSG reductase, NADPH-GSSG reductase, glutathione S-reductase, NADPH:oxidized-glutathione oxidoreductase

Systematic Name: glutathione:NADP⁺ oxidoreductase

Unification Links: BRENDA:1.8.1.7, ENZYME:1.8.1.7, IUBMB-ExplorEnz:1.8.1.7

Supersedes EC number: 1.6.4.2

Reaction:
2 glutathione + NADP⁺ ← glutathione disulfide + NADPH + H⁺

Enzymes and Genes:
glutathione reductase: gor ( Escherichia coli K-12 substr. MG1655 )
glutathione reductase: GSR ( Homo sapiens )
glutathione reductase ( Pisum sativum )
glutathione reductase ( Pisum sativum )

Summary:
Activity is dependent on a redox-active disulfide in each of the active centres.

Citations: [Van53, Racker55, Worthington76, Pigiet77, LibrerosMinotta92, Bohme00]

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References

Bohme00: Bohme CC, Arscott LD, Becker K, Schirmer RH, Williams CH (2000). "Kinetic characterization of glutathione reductase from the malarial parasite Plasmodium falciparum. Comparison with the human enzyme." J Biol Chem 275(48);37317-23. PMID: 10969088

LibrerosMinotta92: Libreros-Minotta CA, Pardo JP, Mendoza-Hernandez G, Rendon JL (1992). "Purification and characterization of glutathione reductase from Rhodospirillum rubrum." Arch Biochem Biophys 298(1);247-53. PMID: 1524433

Pigiet77: Pigiet VP, Conley RR (1977). "Purification of thioredoxin, thioredoxin reductase, and glutathione reductase by affinity chromatography." J Biol Chem 252(18);6367-72. PMID: 330529

Racker55: Racker E (1955). "Glutathione reductase from bakers' yeast and beef liver." J Biol Chem 217(2);855-65. PMID: 13271446

Van53: Van Heyninger R, Pirie A (1953). "Reduction of glutathione coupled with oxidative decarboxylation of malate in cattle lens." Biochem J 53(3);436-44. PMID: 13032091

Worthington76: Worthington DJ, Rosemeyer MA (1976). "Glutathione reductase from human erythrocytes. Catalytic properties and aggregation." Eur J Biochem 67(1);231-8. PMID: 9277

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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