Parent Class:

EC-Numbers → 2 -- Transferases → 2.1 -- Transferring one-carbon groups → 2.1.1 -- Methyltransferases

Synonyms: EcoRI methylase, DNA 5-cytosine methylase, DNA cytosine C⁵ methylase, DNA cytosine methylase, DNA methylase (ambiguous), DNA methyltransferase (ambiguous), DNA transmethylase (ambiguous), DNA-cytosine 5-methylase, DNA-cytosine methyltransferase, HpaII methylase, HpaII′ methylase, M.BsuRIa, M.BsuRIb, Type II DNA methylase, cytosine 5-methyltransferase, cytosine DNA methylase, cytosine DNA methyltransferase, cytosine-specific DNA methyltransferase, deoxyribonucleate methylase (ambiguous), deoxyribonucleate methyltransferase (ambiguous), deoxyribonucleic (cytosine-5-)-methyltransferase, deoxyribonucleic acid (cytosine-5-)-methyltransferase, deoxyribonucleic acid methylase (ambiguous), deoxyribonucleic acid methyltransferase (ambiguous), deoxyribonucleic acid modification methylase (ambiguous), deoxyribonucleic methylase (ambiguous), methylphosphotriester-DNA methyltransferase (ambiguous), modification methylase (ambiguous), restriction-modification system (ambiguous), site-specific DNA-methyltransferase (cytosine-specific), DNA-(cytosine C₅)-methylase

Systematic Name: S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase

Unification Links: BRENDA:2.1.1.37, ENZYME:2.1.1.37, IUBMB-ExplorEnz:2.1.1.37

Reaction:
a cytosine in DNA + S-adenosyl-L-methionine → a 5-methylcytosine in DNA + S-adenosyl-L-homocysteine + H⁺

Enzymes and Genes:
DNA-cytosine methyltransferase: dcm ( Escherichia coli K-12 substr. MG1655 )
DNA (cytosine-5) methyltransferase: Dnmt1 ( Rattus norvegicus )

Citations: [Gold64, Kalousek69, Sneider75, Roy75, Turnbull76, Simon78, Yuan81, Roberts90, Kessler90]

---

References

Gold64: Gold M, Hurwitz J (1964). "The enzymatic methylation of ribonucleic acid and deoxyribonucleic acid. V. Purification and properties of the deoxyribonucleic acid-methylating activity of Escherichia coli." J Biol Chem 239;3858-65. PMID: 14257620

Kalousek69: Kalousek F, Morris NR (1969). "The purification and properties of deoxyribonucleic acid methylase from rat spleen." J Biol Chem 244(5);1157-63. PMID: 4975067

Kessler90: Kessler C, Manta V (1990). "Specificity of restriction endonucleases and DNA modification methyltransferases a review (Edition 3)." Gene 92(1-2);1-248. PMID: 2172084

Roberts90: Roberts RJ (1990). "Restriction enzymes and their isoschizomers." Nucleic Acids Res 18 Suppl;2331-65. PMID: 2159140

Roy75: Roy PH, Weissbach A (1975). "DNA methylase from HeLa cell nuclei." Nucleic Acids Res 2(10);1669-84. PMID: 1187340

Simon78: Simon D, Grunert F, von Acken U, Doring HP, Kroger H (1978). "DNA-methylase from regenerating rat liver: purification and characterisation." Nucleic Acids Res 5(6);2153-67. PMID: 673848

Sneider75: Sneider TW, Teague WM, Rogachevsky LM (1975). "S-adenosylmethionine: DNA-cytosine 5-methyltransferase from a Novikoff rat hepatoma cell line." Nucleic Acids Res 2(10);1685-700. PMID: 171625

Turnbull76: Turnbull JF, Adams RL (1976). "DNA methylase: purification from ascites cells and the effect of various DNA substrates on its activity." Nucleic Acids Res 3(3);677-95. PMID: 131936

Yuan81: Yuan R (1981). "Structure and mechanism of multifunctional restriction endonucleases." Annu Rev Biochem 50;285-319. PMID: 6267988

---

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
Page generated by Pathway Tools version 28.0 (software by SRI International) on Sat Apr 27, 2024, BIOCYC17.