Parent Class:

EC-Numbers → 3 -- Hydrolases → 3.1 -- Acting on ester bonds → 3.1.1 -- Carboxylic ester hydrolases

Synonyms: true cholinesterase, choline esterase I, cholinesterase, acetylthiocholinesterase, acetylcholine hydrolase, acetyl.β-methylcholinesterase, AcCholE

Systematic Name: acetylcholine acetylhydrolase

Unification Links: BRENDA:3.1.1.7, ENZYME:3.1.1.7, IUBMB-ExplorEnz:3.1.1.7

Reaction:
acetylcholine + H₂O → acetate + choline + H⁺

Enzymes and Genes:
acetylcholinesterase: ache ( Tetronarce californica )

Summary:
Acts on a variety of acetic esters; also catalyses transacetylations.

Citations: [Nachmansohn51, Zittle55, Bergmann58, Leuzinger68, Ciliv72]

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References

Bergmann58: Bergmann F, Rimon S, Segal R (1958). "Effect of pH on the activity of eel esterase towards different substrates." Biochem J 68(3);493-9. PMID: 13522650

Ciliv72: Ciliv G, Ozand PT (1972). "Human erythrocyte acetylcholinesterase purification, properties and kinetic behavior." Biochim Biophys Acta 284(1);136-56. PMID: 5073758

Leuzinger68: Leuzinger W, Baker AL, Cauvin E (1968). "Acetylcholinesterase. II. Crystallization, absorption spectra, isoionic point." Proc Natl Acad Sci U S A 59(2);620-3. PMID: 5238989

Nachmansohn51: Nachmansohn D, Wilson IB (1951). "The enzymic hydrolysis and synthesis of acetylcholine." Adv Enzymol Relat Subj Biochem 12;259-339. PMID: 14885021

Zittle55: Zittle CA, Dellamonica ES, Custer JH, Krikorian R (1955). "Purification of human red cell acetylcholinesterase by electrophoresis, ultracentrifugation and gradient extraction." Arch Biochem Biophys 56(2);469-75. PMID: 14377597

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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