MetaCyc EC 3.13.1.1 -- UDP-sulfoquinovose synthase

Parent Class: EC-Numbers → 3 -- Hydrolases → 3.13 -- Acting on carbon-sulfur bonds → 3.13.1 -- Acting on carbon-sulfur bonds

Synonyms: sulfite:UDP-glucose sulfotransferase, UDPsulfoquinovose synthase, UDP-6-sulfo-6-deoxyglucose sulfohydrolase

Systematic Name: UDP-6-sulfo-6-deoxy-α-D-glucose sulfohydrolase

Unification Links: BRENDA:3.13.1.1, ENZYME:3.13.1.1, IUBMB-ExplorEnz:3.13.1.1

Reaction:
UDP-α-D-sulfoquinovopyranose + H2O ← UDP-α-D-glucose + sulfite + H+

Enzymes and Genes:
UDP-sulfoquinovose synthase: sqdB ( Synechococcus elongatus PCC 7942 = FACHB-805 )
UDP-sulfoquinovose synthase: SQD1 ( Arabidopsis thaliana col )

Summary:
Requires NAD+, which appears to oxidize the substrate to UDP-4-dehydroglucose, which dehydrates to UDP-4-dehydro-6-deoxygluc-5-enose, to which sulfite can add; the reaction is completed when the substrate is rehydrogenated at C-4. The enzyme from Arabidopsis thaliana is specific for UDP-Glc and sulfite.

Citations: [Essigmann98, Essigmann99, Mulichak99, Sanda01]

References

Essigmann98: Essigmann B, Guler S, Narang RA, Linke D, Benning C (1998). "Phosphate availability affects the thylakoid lipid composition and the expression of SQD1, a gene required for sulfolipid biosynthesis in Arabidopsis thaliana." Proc Natl Acad Sci U S A 1998;95(4);1950-5. PMID: 9465123

Essigmann99: Essigmann B, Hespenheide BM, Kuhn LA, Benning C (1999). "Prediction of the active-site structure and NAD(+) binding in SQD1, a protein essential for sulfolipid biosynthesis in Arabidopsis." Arch Biochem Biophys 369(1);30-41. PMID: 10462438

Mulichak99: Mulichak AM, Theisen MJ, Essigmann B, Benning C, Garavito RM (1999). "Crystal structure of SQD1, an enzyme involved in the biosynthesis of the plant sulfolipid headgroup donor UDP-sulfoquinovose." Proc Natl Acad Sci U S A 1999;96(23);13097-102. PMID: 10557279

Sanda01: Sanda S, Leustek T, Theisen MJ, Garavito RM, Benning C (2001). "Recombinant Arabidopsis SQD1 converts udp-glucose and sulfite to the sulfolipid head group precursor UDP-sulfoquinovose in vitro." J Biol Chem 2001;276(6);3941-6. PMID: 11073956

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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