MetaCyc EC 6.2.1.22 -- [citrate (pro-3S)-lyase] ligase

Parent Class: EC-Numbers → 6 -- Ligases → 6.2 -- Forming carbon-sulfur bonds → 6.2.1 -- Acid--thiol ligases

Synonyms: citrate lyase ligase, citrate lyase synthetase, acetate: SH-[acyl-carrier-protein] enzyme ligase (AMP), acetate:HS-citrate lyase ligase, acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming), acetate:[citrate-(pro-3S)-lyase](thiol-form) ligase (AMP-forming)

Systematic Name: acetate:holo-[citrate-(pro-3S)-lyase] ligase (AMP-forming)

Unification Links: BRENDA:6.2.1.22, ENZYME:6.2.1.22, IUBMB-ExplorEnz:6.2.1.22

Reaction:
holo [citrate lyase acyl-carrier protein] + acetate + ATP → acetyl-holo [citrate lyase acyl-carrier protein] + AMP + diphosphate

Enzymes and Genes:
[citrate [pro-3S]-lyase] ligase: citC ( Klebsiella pneumoniae )

Summary:
Both this enzyme and EC 2.3.1.49, deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase, acetylate and activate EC 4.1.3.6, citrate (pro-3S)-lyase.

Citations: [Schmellenkamp74, Antranikian82, Quentmeier85, Antranikian85]

References

Antranikian82: Antranikian G, Gottschalk G (1982). "Copurification of citrate lyase and citrate lyase ligase from Rhodopseudomonas gelatinosa and subsequent separation of the two enzymes." Eur J Biochem 126(1);43-7. PMID: 7128585

Antranikian85: Antranikian G, Herzberg C, Gottschalk G (1985). "Covalent modification of citrate lyase ligase from Clostridium sphenoides by phosphorylation/dephosphorylation." Eur J Biochem 153(2);413-20. PMID: 3935436

Quentmeier85: Quentmeier A, Antranikian G (1985). "Characterization of citrate lyase from Clostridium sporosphaeroides." Arch Microbiol 141(1);85-90. PMID: 3994485

Schmellenkamp74: Schmellenkamp H, Eggerer H (1974). "Mechanism of enzymic acetylation of des-acetyl citrate lyase." Proc Natl Acad Sci U S A 71(5);1987-91. PMID: 4365579

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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