Parent Class:

EC-Numbers → 6 -- Ligases → 6.2 -- Forming carbon-sulfur bonds → 6.2.1 -- Acid--thiol ligases

Synonyms: NcsB2

Systematic Name: 2-hydroxy-7-methoxy-5-methyl-1-naphthoate:CoA ligase

Unification Links: BRENDA:6.2.1.43, ENZYME:6.2.1.43, IUBMB-ExplorEnz:6.2.1.43

Reaction:
ATP + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + coenzyme A → AMP + 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA + diphosphate

Summary:
The enzyme from the bacterium Streptomyces carzinostaticus is involved in the attachment of the 2-hydroxy-7-methoxy-5-methyl-1-naphthoate moiety of the antitumor antibiotic neocarzinostatin. In vitro the enzyme also catalyses the activation of other 1-naphthoic acid analogues, e.g. 2-hydroxy-5-methyl-1-naphthoate or 2,7-dihydroxy-5-methyl-1-naphthoate.

Citations: [Cooke07]

---

References

Cooke07: Cooke HA, Zhang J, Griffin MA, Nonaka K, Van Lanen SG, Shen B, Bruner SD (2007). "Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin." J Am Chem Soc 129(25);7728-9. PMID: 17539640

---

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
Page generated by Pathway Tools version 28.0 (software by SRI International) on Sun Apr 28, 2024, BIOCYC16.