Chapter 3
Chapter 3. Osteoclast Biology and Bone Resorption
F. Patrick Ross,
F. Patrick Ross
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F. Patrick Ross,
F. Patrick Ross
Search for more papers by this author
Book Author(s):ASBMR,
Summary
This chapter contains sections titled:
Cell Biology of the Osteoclast
Integrin Signaling
Small Gtpases
Factors Regulating Osteoclast Formation and/or Function
References
- Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ 1999 Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 20: 345–357.
- Boyle WJ, Simonet WS, Lacey DL 2003 Osteoclast differentiation and activation. Nature 423: 337–342.
- Pixley FJ, Stanley ER 2004 CSF-1 regulation of the wandering macrophage: Complexity in action. Trends Cell Biol 14: 628–638.
- Weitzmann MN, Cenci S, Rifas L, Brown C, Pacifici R 2000 IL-7 stimulates osteoclast formation by upregulating the T-cell production of soluble osteoclastogenic cytokines. Blood 96: 1873–1878.
- Kostenuik PJ, Shalhoub V 2001 Osteoprotegerin: A physiological and pharmacological inhibitor of bone resorption. Curr Pharm Des 7: 613–635.
- Teitelbaum SL, Ross FP 2003 Genetic regulation of osteoclast development and function. Nat Rev Genet 4: 638–649.
- Salo J, Lehenkari P, Mulari M, Metsikko K, Vaananen HK 1997 Removal of osteoclast bone resorption products by transcytosis. Science 276: 270–273.
- Stenbeck G, Horton MA 2004 Endocytic trafficking in actively resorbing osteoclasts. J Cell Sci 117: 827–836.
- Hynes RO 2002 Integrins: Bidirectional, allosteric signaling machines. Cell 110: 673–687.
- Ross FP, Teitelbaum SL 2005 αvβ3 and macrophage colony-stimulating factor: Partners in osteoclast biology. Immunol Rev 208: 88–105.
- Teitelbaum SL 2005 Osteoporosis and integrins. J Clin Endocrinol Metab 90: 2466–2468.
- Teitelbaum SL, Abu-Amer Y, Ross FP 1995 Molecular mechanisms of bone resorption. J Cell Biochem 59: 1–10.
- Van Wesenbeeck L, Odgren PR, Coxon FP, Frattini A, Moens P, Perdu B, MacKay CA, Van Hul E, Timmermans JP, Vanhoenacker F, Jacobs R, Peruzzi B, Teti A, Helfrich MH, Rogers MJ, Villa A, Van Hul W 2007 Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans. J Clin Invest 117: 919–930.
- Vaananen HK, Zhao H, Mulari M, Halleen JM 2000 The cell biology of osteoclast function. J Cell Sci 113: 377–381.
- Schwartz MA, Ginsberg MH 2002 Networks and crosstalk: Integrin signalling spreads. Nat Cell Biol 4: E65–E68.
- Horne WC, Sanjay A, Bruzzaniti A, Baron R 2005 The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function. Immunol Rev 208: 106–125.
- Zou W, Kitaura H, Reeve J, Long F, Tybulewicz VLJ, Shattil SJ, Ginsberg MH, Ross FP, Teitelbaum SL 2007 Syk, c-Src, the αvβ3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol 176: 877–888.
- Jaffe AB, Hall A 2005 Rho GTPases: Biochemistry and biology. Annu Rev Cell Dev Biol 21: 247–269.
- Chellaiah MA 2005 Regulation of actin ring formation by rho GTPases in osteoclasts. J Biol Chem 280: 32930–32943.
- Fukuda A, Hikita A, Wakeyama H, Akiyama T, Oda H, Nakamura K, Tanaka S 2005 Regulation of osteoclast apoptosis and motility by small GTPase binding protein Racl. J Bone Miner Res 20: 2245–2253.
- Faccio R, Teitelbaum SL, Fujikawa K, Chappel JC, Zallone A, Tybulewicz VL, Ross FP, Swat W 2005 Vav3 regulates osteoclast function and bone mass. Nat Med 11: 284–290.
- Whyte MP, Obrecht SE, Finnegan PM, Jones JL, Podgornik MN, McAlister WH, Mumm S 2002 Osteoprotegerin deficiency and juvenile Paget's disease. N Engl J Med 347: 175–184.
- Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, Shimamoto G, DeRose M, Elliott R, Colombero A, Tan HL, Trail G, Sullivan J, Davy E, Bucay N, Renshaw-Gegg L, Hughes TM, Hill D, Pattison W, Campbell P, Sander S, Van G, Tarpley J, Derby J, Lee R, Boyle WJ 1997 Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cell 89: 309–319.
- Clines GA, Guise TA 2005 Hypercalcaemia of malignancy and basic research on mechanisms responsible for osteolytic and osteoblastic metastasis to bone. Endocr Relat Cancer 12: 549–583.
- Martin TJ 2002 Manipulating the environment of cancer cells in bone: A novel therapeutic approach. J Clin Invest 110: 1399–1401.
- Zwerina J, Redlich K, Schett G, Smolen JS 2005 Pathogenesis of rheumatoid arthritis: Targeting cytokines. Ann NY Acad Sci 1051: 716–729.
- Zwerina J, Hayer S, Tohidast-Akrad M, Bergmeister H, Redlich K, Feige U, Dunstan C, Kollias G, Steiner G, Smolen J, Schett G 2004 Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: Effects on synovial inflammation, bone erosion, and cartilage destruction. Arthritis Rheum 50: 277–290.
- Takayanagi H 2005 Mechanistic insight into osteoclast differentiation in osteoimmunology. J Mol Med 83: 170–179.
- Key LL, Rodriguiz RM, Willi SM, Wright NM, Hatcher HC, Eyre DR, Cure JK, Griffin PP, Ries WL 1995 Long-term treatment of osteopetrosis with recombinant human interferon gamma. N Engl J Med 332: 1594–1599.
- Cenci S, Toraldo G, Weitzmann MN, Roggia C, Gao Y, Qian WP, Sierra O, Pacifici R 2003 Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-μ-induced class II transactivator. Proc Natl Acad Sci USA 100: 10405–10410.
- Kim MS, Day CJ, Selinger CI, Magno CL, Stephens SRJ, Morrison NA 2006 MCP-1-induced human osteoclast-like cells are tartrate-resistant acid phosphatase, NFATcl, and calcitonin receptor-positive but require receptor activator of NFκB ligand for bone resorption. J Biol Chem 281: 1274–1285.
- Stockinger B, Veldhoen M 2007 Differentiation and function of Th17 T cells. Curr Opin Immunol 19: 281–286.
- Udagawa N 2003 The mechanism of osteoclast differentiation from macrophages: Possible roles of T lymphocytes in osteoclastogenesis. J Bone Miner Metab 21: 337–343.
- Goltzman D, Miao D, Panda DK, Hendy GN 2004 Effects of calcium and of the Vitamin D system on skeletal and calcium homeostasis: Lessons from genetic models. J Steroid Biochem Mol Biol 89–90: 485–489.
- Syed F, Khosla S 2005 Mechanisms of sex steroid effects on bone. Biochem Biophys Res Commun 328: 688–696.
- Eastell R 2005 Role of oestrogen in the regulation of bone turnover at the menarche. J Endocrinol 185: 223–234.
- Canalis E, Bilezikian JP, Angeli A, Giustina A 2004 Perspectives on glucocorticoid-induced osteoporosis. Bone 34: 593–598.
- Weinstein RS, Chen J-R, Powers CC, Stewart SA, Landes RD, Bellido T, Jilka RL, Parfitt AM, Manolagas SC 2002 Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids. J Clin Invest 109: 1041–1048.
- Kobayashi T, Narumiya S 2002 Function of prostanoid receptors: Studies on knockout mice. Prostaglandins Other Lipids Mediat 68–69: 557–573.
- Golden LH, Insogna KL 2004 The expanding role of P13-kinase in bone. Bone 34: 3–12.
- DiNitto JP, Cronin TC, Lambright DG 2003 Membrane recognition and targeting by lipid-binding domains. Sci STKE 2003: re16.
- Nakashima T, Wada T, Penninger JM 2003 RANKL and RANK as novel therapeutic targets for arthritis. Curr Opin Rheumatol 15: 280–287.
- Taubman MA, Valverde P, Han X, Kawai T 2005 Immune response: The key to bone resorption in periodontal disease. J Periodontol 76: 2033–2041.
- Suda T, Arai F, Hirao A 2005 Hematopoietic stem cells and their niche. Trends Immunol 26: 426–433.
- Taichman RS 2005 Blood and bone: Two tissues whose fates are intertwined to create the hematopoietic stem-cell niche. Blood 105: 2631–2639.
- Bendre M, Gaddy D, Nicholas RW, Suva LJ 2003 Breast cancer metastasis to bone: It is not all about PTHrP. Clin Orthop 415(Suppl): S39–S45.
- Hata H 2005 Bone lesions and macrophage inflammatory protein-1 alpha (MIP-la) in human multiple myeloma. Leuk Lymphoma 46: 967–972.
- Kim MS, Day CJ, Morrison NA 2005 MCP-1 is induced by receptor activator of nuclear factor κB ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony-stimulating factor suppression of osteoclast formation. J Biol Chem 280: 16163–16169.
- Seales EC, Micoli KJ, McDonald JM 2006 Calmodulin is a critical regulator of osteoclastic differentiation, function, and survival. J Cell Biochem 97: 45–55.
- Ross FP 2006 M-CSF, c-Fms and signaling in osteoclasts and their precursors. Ann NY Acad Sci 1068: 110–116.
- Rogers MJ 2004 From molds and macrophages to mevalonate: A decade of progress in understanding the molecular mode of action of bisphosphonates. Calcif Tissue Int 75: 451–461.
- Blair HC, Robinson LJ, Zaidi M 2005 Osteoclast signalling pathways. Biochem Biophys Res Commun 328: 728–738.
- Feng X 2005 Regulatory roles and molecular signaling of TNF family members in osteoclasts. Gene 350: 1–13.
- Hershey CL, Fisher DE 2004 Mitf and Tfe3: Members of a b-HLH-ZIP transcription factor family essential for osteoclast development and function. Bone 34: 689–696.
- Lee ZH, Kim H-H 2003 Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts. Biochem Biophys Res Commun 305: 211–214.
- Wagner EF, Eferl R 2005 Fos/AP-1 proteins in bone and the immune system. Immunol Rev 208: 126–140.
