Review
Hydrogels as Emerging Materials for Cornea Wound Healing
Sadjad Khosravimelal,
Mohammadmahdi Mobaraki,
Samane Eftekhari,
Mark Ahearne,
Alexander Marcus Seifalian,
Mazaher Gholipourmalekabadi,
Sadjad Khosravimelal
Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, 1449614535 Iran
Cellular and Molecular Research Centre, Iran University of Medical Sciences, Tehran, 1449614535 Iran
Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, 1449614535 Iran
Search for more papers by this authorMohammadmahdi Mobaraki
Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, 1591634311 Iran
Search for more papers by this authorSamane Eftekhari
Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, 1449614535 Iran
Cellular and Molecular Research Centre, Iran University of Medical Sciences, Tehran, 1449614535 Iran
Search for more papers by this authorMark Ahearne
Trinity Centre for Biomedical Engineering, School of Engineering, Trinity College Dublin, University of Dublin, Dublin, D02 R590 Republic of Ireland
Search for more papers by this authorCorresponding Author
Alexander Marcus Seifalian
Nanotechnology & Regenerative Medicine Commercialization Centre (NanoRegMed Ltd), London BioScience Innovation Centre, London, NW1 0NH UK
E-mail: [email protected], [email protected]
Search for more papers by this authorCorresponding Author
Mazaher Gholipourmalekabadi
Cellular and Molecular Research Centre, Iran University of Medical Sciences, Tehran, 1449614535 Iran
Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, 1449614535 Iran
E-mail: [email protected], [email protected]
Search for more papers by this author
Sadjad Khosravimelal,
Mohammadmahdi Mobaraki,
Samane Eftekhari,
Mark Ahearne,
Alexander Marcus Seifalian,
Mazaher Gholipourmalekabadi,
Sadjad Khosravimelal
Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, 1449614535 Iran
Cellular and Molecular Research Centre, Iran University of Medical Sciences, Tehran, 1449614535 Iran
Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, 1449614535 Iran
Search for more papers by this authorMohammadmahdi Mobaraki
Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, 1591634311 Iran
Search for more papers by this authorSamane Eftekhari
Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, 1449614535 Iran
Cellular and Molecular Research Centre, Iran University of Medical Sciences, Tehran, 1449614535 Iran
Search for more papers by this authorMark Ahearne
Trinity Centre for Biomedical Engineering, School of Engineering, Trinity College Dublin, University of Dublin, Dublin, D02 R590 Republic of Ireland
Search for more papers by this authorCorresponding Author
Alexander Marcus Seifalian
Nanotechnology & Regenerative Medicine Commercialization Centre (NanoRegMed Ltd), London BioScience Innovation Centre, London, NW1 0NH UK
E-mail: [email protected], [email protected]
Search for more papers by this authorCorresponding Author
Mazaher Gholipourmalekabadi
Cellular and Molecular Research Centre, Iran University of Medical Sciences, Tehran, 1449614535 Iran
Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, 1449614535 Iran
E-mail: [email protected], [email protected]
Search for more papers by this authorAbstract
Hydrogel biomaterials have many favorable characteristics including tuneable mechanical behavior, cytocompatibility, optical properties suitable for regeneration and restoration of the damaged cornea tissue. The cornea is a tissue susceptible to various injuries and traumas with a complicated healing cascade, in which conserving its transparency and integrity is critical. Accordingly, the hydrogels’ known properties along with the stimulation of nerve and cell regeneration make them ideal scaffold for corneal tissue engineering. Hydrogels have been used extensively in clinical applications for the repair and replacement of diseased organs. The development and optimizing of novel hydrogels to repair/replace corneal injuries have been the main focus of researches within the last decade. This research aims to critically review in vitro, preclinical, as well as clinical trial studies related to corneal wound healing using hydrogels in the past 10 years, as this is considered as an emerging technology for corneal treatment. Several unique modifications of hydrogels with smart behaviors have undergone early phase clinical trials and showed promising outcomes. Financially, this considers a multibillion dollars industry and with huge interest from medical devices as well as pharmaceutical industries with several products may emerge within the next five years.
Conflict of Interest
The authors declare no conflict of interest.
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