Advanced Review
Nanotechnology platforms for cancer immunotherapy
Zhaogang Yang,
Yifan Ma,
Hai Zhao,
Yuan Yuan,
Betty Y. S. Kim,
Zhaogang Yang
Department of Radiation Oncology, The University of Texas Southwestern Medical Center, Dallas, Texas
Search for more papers by this authorYifan Ma
Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio
Search for more papers by this authorHai Zhao
Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorYuan Yuan
Engineering Research Center for Biomaterials of Ministry of Education, East China University of Science and Technology, Shanghai, China
Search for more papers by this authorCorresponding Author
Betty Y. S. Kim
Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas
Correspondence
Betty Y. S. Kim, Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Email: [email protected];
Search for more papers by this author
Zhaogang Yang,
Yifan Ma,
Hai Zhao,
Yuan Yuan,
Betty Y. S. Kim,
Zhaogang Yang
Department of Radiation Oncology, The University of Texas Southwestern Medical Center, Dallas, Texas
Search for more papers by this authorYifan Ma
Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio
Search for more papers by this authorHai Zhao
Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas
Search for more papers by this authorYuan Yuan
Engineering Research Center for Biomaterials of Ministry of Education, East China University of Science and Technology, Shanghai, China
Search for more papers by this authorCorresponding Author
Betty Y. S. Kim
Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas
Correspondence
Betty Y. S. Kim, Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Email: [email protected];
Search for more papers by this author
Zhaogang Yang and Yifan Ma contributed equally to this study.
Funding information: Congressionally Directed Medical Research Programs, Grant/Award Number: BC181476; National Institute of Neurological Disorders and Stroke, Grant/Award Number: R01 NS104315
Abstract
Various cancer therapies have advanced remarkably over the past decade. Unlike the direct therapeutic targeting of tumor cells, cancer immunotherapy is a new strategy that boosts the host's immune system to detect specific cancer cells for efficient elimination. Nanoparticles incorporating immunomodulatory agents can activate immune cells and modulate the tumor microenvironment to enhance antitumor immunity. Such nanoparticle-based cancer immunotherapies have received considerable attention and have been extensively studied in recent years. This review thus focuses on nanoparticle-based platforms (especially naturally derived nanoparticles and synthetic nanoparticles) utilized in recent advances; summarizes delivery systems that incorporate various immune-modulating agents, including peptides and nucleic acids, immune checkpoint inhibitors, and other small immunostimulating agents; and introduces combinational cancer immunotherapy with nanoparticles, especially nanoparticle-based photo-immunotherapy and nanoparticle-based chemo-immunotherapy. Undoubtedly, the recent studies introduced in this review prove that nanoparticle-incorporated cancer immunotherapy is a highly promising treatment modality for patients with cancer. Nonetheless further research is needed to solve safety concerns and improve efficacy of nanoplatform-based cancer immunotherapy for future clinical application.
This article is categorized under:
- Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
Graphical Abstract
Immune actions in the cycle of cancer immunotherapy. Nanomaterials can be engineered to improve cancer immunotherapies by targeting multiple immune activating and suppressive processes along the immunological cascade to improve its effectiveness in patients.
CONFLICT OF INTEREST
The authors have declared no conflicts of interest for this article.
Supporting Information
| Filename | Description |
|---|---|
| wnan1590-sup-0001-Supinfo.docWord document, 9.2 MB | Appendix S1: Supplementary Material |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
FURTHER READING
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