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The Structural And Functional Diversity Of The Myosin Family Of Actin-Based Molecular Motors

  • Chapter
Myosins

Part of the book series: Proteins and Cell Regulation ((PROR,volume 7))

Abstract

In this chapter, a broad overview of the myosin family of actin-based motors with respect to diversity of myosin-domain structures and cellular functions will be outlined.It is meant as a backdrop for the more detailed discussions of the various myosin classes found in the chapters that follow. This is not intended to be a comprehensive review;rather selected examples will be discussed to highlight the remarkable structural and functional diversity within this family of actin-filament-based molecular motors.

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References

  • Al-Haddad, A., M. A. Shonn, B. Redlich, A. Blocker, J. K. Burkhardt, H. Yu, J. A. Hammer, 3rd, D. G. Weiss, W. Steffen, G. Griffiths, and S. A. Kuznetsov. (2001). Myosin va bound to phagosomes binds to f-actin and delays microtubule-dependent motility. Mol Biol Cell 12, 2742–55.

    PubMed  CAS  Google Scholar 

  • Ali, M. Y., E. B. Krementsova, G. G. Kennedy, R. Mahaffy, T. D. Pollard, K. M. Trybus, and D. M. Warshaw. (2007). Myosin Va maneuvers through actin intersections and diffuses along microtubules. Proc Natl Acad Sci USA 104, 4332–6.

    Article  PubMed  CAS  Google Scholar 

  • Araki, N. (2006). Role of microtubules and myosins in Fc gamma receptor-mediated phagocytosis. Front Biosci 11, 1479–90.

    Article  PubMed  CAS  Google Scholar 

  • Barral, D.C., and M.C. Seabra. (2004). The melanosome as a model to study organelle motility in mammals. Pigment Cell Res 17, 111–8.

    Article  PubMed  Google Scholar 

  • Bement, W.M., and M.S. Mooseker. (1995). TEDS rule: a molecular rationale for differential regulation of myosins by phosphorylation of the heavy chain head. Cell Motil Cytoskeleton 31, 87–92.

    Article  PubMed  CAS  Google Scholar 

  • Berg, J. S., B. C. Powell, and R. E. Cheney. (2001). A millennial myosin census. Mol Biol Cell 12, 780–94.

    PubMed  CAS  Google Scholar 

  • Bose, A., S. Robida, P. S. Furcinitti, A. Chawla, K. Fogarty, S. Corvera, and M. P. Czech. (2004). Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway. Mol Cell Biol 24, 5447–58.

    Article  PubMed  CAS  Google Scholar 

  • Bridgman, P. C. (1999). Myosin Va movements in normal and dilute-lethal axons provide support for a dual filament motor complex. J Cell Biol 146, 1045–60.

    Article  PubMed  CAS  Google Scholar 

  • Brown, M. E., and P. C. Bridgman. (2003). Retrograde flow rate is increased in growth cones from myosin IIB knockout mice. J Cell Sci 116, 1087–94.

    Article  PubMed  CAS  Google Scholar 

  • Buss, F., J. Kendrick-Jones, C. Lionne, A. E. Knight, G. P. Cote, and J. P. Luzio. (1998). The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation. J Cell Biol 143, 1535–45.

    Article  PubMed  CAS  Google Scholar 

  • Buss, F., G. Spudich, and J. Kendrick-Jones. (2004). Myosin VI: cellular functions and motor properties. Annu Rev Cell Dev Biol 20, 649–76.

    Article  PubMed  CAS  Google Scholar 

  • Cameron, R. S., C. Liu, A. S. Mixon, J. P. Pihkala, R. J. Rahn, and P. L. Cameron. (2007). Myosin16b: The COOH-tail region directs localization to the nucleus and overexpression delays S-phase progression. Cell Motil Cytoskeleton 64, 19–48.

    Article  PubMed  CAS  Google Scholar 

  • Cao, T. T., W. Chang, S. E. Masters, and M. S. Mooseker. (2004). Myosin-Va binds to and mechanochemically couples microtubules to actin filaments. Mol Biol Cell 15:151–61.

    Article  PubMed  CAS  Google Scholar 

  • Cheney, R. E., and M. S. Mooseker. (1992). Unconventional myosins. Curr Opin Cell Biol 4, 27–35.

    Article  PubMed  CAS  Google Scholar 

  • Cheney, R. E., M. A. Riley, and M. S. Mooseker. (1993). Phylogenetic analysis of the myosin superfamily. Cell Motil Cytoskeleton 24, 215–23.

    Article  PubMed  CAS  Google Scholar 

  • Chuang, C. H., A. E. Carpenter, B. Fuchsova, T. Johnson, P. de Lanerolle, and A. S. Belmont. (2006). Long-range directional movement of an interphase chromosome site. Curr Biol 16, 825–31.

    Article  PubMed  CAS  Google Scholar 

  • Clark, R., M. A. Ansari, S. Dash, M. A. Geeves, and L. M. Coluccio. (2005). Loop 1 of transducer region in mammalian class I myosin, Myo1b, modulates actin affinity, ATPase activity, and nucleotide access. J Biol Chem 280, 30935–42.

    Article  PubMed  CAS  Google Scholar 

  • Cox, D., J. S. Berg, M. Cammer, J. O. Chinegwundoh, B. M. Dale, R. E. Cheney, and S. Greenberg. (2002). Myosin X is a downstream effector of PI(3)K during phagocytosis. Nat Cell Biol 4, 469–77.

    PubMed  CAS  Google Scholar 

  • Dance, A. L., M. Miller, S. Seragaki, P. Aryal, B. White, L. Aschenbrenner, and T. Hasson. (2004). Regulation of myosin-VI targeting to endocytic compartments. Traffic. 5, 798–813.

    Article  PubMed  CAS  Google Scholar 

  • D’Andrea, L. D., and L. Regan. (2003). TPR proteins: the versatile helix. Trends Biochem Sci 28, 655–62.

    Article  PubMed  CAS  Google Scholar 

  • de Lanerolle, P., T. Johnson, and W. A. Hofmann. (2005). Actin and myosin I in the nucleus: what next? Nat Struct Mol Biol 12, 742–6.

    Article  PubMed  CAS  Google Scholar 

  • Dekker-Ohno, K., S. Hayasaka, Y. Takagishi, S. Oda, N. Wakasugi, K. Mikoshiba, M. Inouye, and H. Yamamura. (1996). Endoplasmic reticulum is missing in dendritic spines of Purkinje cells of the ataxic mutant rat. Brain Res 714, 226–30.

    Article  PubMed  CAS  Google Scholar 

  • Delprat, B., V. Michel, R. Goodyear, Y. Yamasaki, N. Michalski, A. El-Amraoui, I. Perfettini, P. Legrain, G. Richardson, J.P. Hardelin, and C. Petit. (2005). Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly. Hum Mol Genet 14, 401–10.

    Article  PubMed  CAS  Google Scholar 

  • Diefenbach, T. J., V. M. Latham, D. Yimlamai, C. A. Liu, I. M. Herman, and D. G. Jay. (2002). Myosin1c and myosin IIB serve opposing roles in lamellipodial dynamics of the neuronal growth cone. J Cell Biol 158, 1207–17.

    Article  PubMed  CAS  Google Scholar 

  • Dunn, T. A., S. Chen, D. A. Faith, J. L. Hicks, E. A. Platz, Y. Chen, C. M. Ewing, J. Sauvageot, W. B. Isaacs, A. M. De Marzo, and J. Luo. (2006). A novel role of myosin VI in human prostate cancer. Am J Pathol 169, 1843–54.

    Article  PubMed  CAS  Google Scholar 

  • Durrwang, U., S. Fujita-Becker, M. Erent, F. J. Kull, G. Tsiavaliaris, M. A. Geeves, and D. J. Manstein. (2006). Dictyostelium myosin-IE is a fast molecular motor involved in phagocytosis. J Cell Sci. 119, 550–8.

    Article  PubMed  CAS  Google Scholar 

  • Eichler, T. W., T. Kogel, N. V. Bukoreshtliev, and H. H. Gerdes. (2006). The role of myosin Va in secretory granule trafficking and exocytosis. Biochem Soc Trans 34, 671–4.

    Article  PubMed  CAS  Google Scholar 

  • El-Amraoui, A., J. S. Schonn, P. Kussel-Andermann, S. Blanchard, C. Desnos, J. P. Henry, U. Wolfrum, F. Darchen, and C. Petit. (2002). MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes. EMBO Rep 3, 463–70.

    Article  PubMed  CAS  Google Scholar 

  • Engqvist-Goldstein, A. E., and D. G. Drubin. (2003). Actin assembly and endocytosis: from yeast to mammals. Annu Rev Cell Dev Biol 19, 287–332.

    Article  PubMed  CAS  Google Scholar 

  • Espindola, F. S., D. M. Suter, L. B. Partata, T. Cao, J. S. Wolenski, R. E. Cheney, S. M. King, and M. S. Mooseker. (2000). The light chain composition of chicken brain myosin-Va: calmodulin, myosin-II essential light chains, and 8-kDa dynein light chain/PIN. Cell Motil Cytoskeleton 47, 269–81.

    Article  PubMed  CAS  Google Scholar 

  • Espreafico, E. M., R. E. Cheney, M. Matteoli, A. A. Nascimento, P. V. De Camilli, R. E. Larson, and M. S. Mooseker. (1992). Primary structure and cellular localization of chicken brain myosin-V (p190), an unconventional myosin with calmodulin light chains. J Cell Biol 119, 1541–57.

    Article  PubMed  CAS  Google Scholar 

  • Estrada, P., J. Kim, J. Coleman, L. Walker, B. Dunn, P. Takizawa, P. Novick, and S. Ferro-Novick. (2003). Myo4p and She3p are required for cortical ER inheritance in Saccharomyces cerevisiae. J Cell Biol 163, 1255–66.

    Article  PubMed  CAS  Google Scholar 

  • Evans, L. L., A. J. Lee, P. C. Bridgman, and M. S. Mooseker. (1998). Vesicle-associated brain myosin-V can be activated to catalyze actin-based transport. JCell Sci 111 (Pt 14), 2055–66.

    CAS  Google Scholar 

  • Fath, K. R. (2005). Characterization of myosin-II binding to Golgi stacks in vitro. Cell Motil Cytoskeleton 60, 222–35.

    Article  PubMed  CAS  Google Scholar 

  • Foth, B. J., M. C. Goedecke, and D. Soldati. (2006). New insights into myosin evolution and classification. Proc Natl Acad Sci USA 103, 3681–6.

    Article  PubMed  CAS  Google Scholar 

  • Frank, D. J., S. R. Martin, B. N. Gruender, Y. S. Lee, R. A. Simonette, P. M. Bayley, K. G. Miller, and K. M. Beckingham. (2006). Androcam is a tissue-specific light chain for myosin VI in the Drosophila testis. J Biol Chem 281, 24728–36.

    Article  PubMed  CAS  Google Scholar 

  • Fujita-Becker, S., G. Tsiavaliaris, R. Ohkura, T. Shimada, D. J. Manstein, and K. Sutoh. (2006). Functional characterization of the N-terminal region of myosin-2. J Biol Chem 281, 36102–9.

    Article  PubMed  CAS  Google Scholar 

  • Geisbrecht, E. R., and D. J. Montell. (2002). Myosin VI is required for E-cadherin-mediated border cell migration. Nat Cell Biol 4, 616–20.

    PubMed  CAS  Google Scholar 

  • Gibbs, D., S. M. Azarian, C. Lillo, J. Kitamoto, A. E. Klomp, K. P. Steel, R. T. Libby, and D. S. Williams. (2004). Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes. J Cell Sci 117, 6473–83.

    Article  PubMed  CAS  Google Scholar 

  • Gibbs, D., J. Kitamoto, and D. S. Williams. (2003). Abnormal phagocytosis by retinal pigmented epithelium that lacks myosin VIIa, the Usher syndrome 1B protein. Proc Natl Acad Sci USA 100, 6481–6.

    Article  PubMed  CAS  Google Scholar 

  • Gill, T., J. Aulds, and M. E. Schmitt. (2006). A specialized processing body that is temporally and asymmetrically regulated during the cell cycle in Saccharomyces cerevisiae. J Cell Biol 173, 35–45.

    Article  PubMed  CAS  Google Scholar 

  • Gillespie, P. G., and J. L. Cyr. (2004). Myosin-1c, the hair cell’s adaptation motor. Annu Rev Physiol 66, 521–45.

    Article  PubMed  CAS  Google Scholar 

  • Gonsalvez, G. B., C. R. Urbinati, and R. M. Long. (2005). RNA localization in yeast: moving towards a mechanism. Biol Cell 97, 75–86.

    Article  PubMed  CAS  Google Scholar 

  • Goodson, H. V., and S. C. Dawson. (2006). Multiplying myosins. Proc Natl Acad Sci USA 103, 3498–9.

    Article  PubMed  CAS  Google Scholar 

  • Goodson, H. V., and J. A. Spudich. (1993). Molecular evolution of the myosin family: relationships derived from comparisons of amino acid sequences. Proc Natl Acad Sci USA 90, 659–63.

    Article  PubMed  CAS  Google Scholar 

  • Grosshans, B. L., H. Grotsch, D. Mukhopadhyay, I. M. Fernandez, J. Pfannstiel, F. Z. Idrissi, J. Lechner, H. Riezman, and M. I. Geli. (2006). TEDS site phosphorylation of the yeast myosins I is required for ligand-induced but not for constitutive endocytosis of the G protein-coupled receptor Ste2p. J Biol Chem 281, 11104–14.

    Article  PubMed  CAS  Google Scholar 

  • Hasson, T. (2003). Myosin VI: two distinct roles in endocytosis. J Cell Sci 116, 3453–61.

    Article  PubMed  CAS  Google Scholar 

  • Heintzelman, M. B. (2006). Cellular and molecular mechanics of gliding locomotion in eukaryotes. Int Rev Cytol 251, 79–129.

    PubMed  CAS  Google Scholar 

  • Herm-Gotz, A., S. Weiss, R. Stratmann, S. Fujita-Becker, C. Ruff, E. Meyhofer, T. Soldati, D. J. Manstein, M. A. Geeves, and D. Soldati. (2002). Toxoplasma gondii myosin A and its light chain: a fast, single-headed, plus-end-directed motor. Embo J. 21, 2149–58.

    Article  PubMed  CAS  Google Scholar 

  • Hofmann, W. A., T. Johnson, M. Klapczynski, J. L. Fan, and P. de Lanerolle. (2006a). From transcription to transport: emerging roles for nuclear myosin I. Biochem Cell Biol 84, 418–26.

    Article  CAS  Google Scholar 

  • Hofmann, W. A., G. M. Vargas, R. Ramchandran, L. Stojiljkovic, J.A. Goodrich, and P. de Lanerolle. (2006b). Nuclear myosin I is necessary for the formation of the first phosphodiester bond during transcription initiation by RNA polymerase II. J Cell Biochem 99, 1001–9.

    Article  CAS  Google Scholar 

  • Holt, J. P., K. Bottomly and M. S. Moosekar. (2007). Assessment of myosin II, Va, VI and VIIa loss of function on endocytosis and endocytic vesicle motility in bone marrow-derived dendritic cells. Cell Motil Cytoskeleton. In press.

    Google Scholar 

  • Hozumi, S., R. Maeda, K. Taniguchi, M. Kanai, S. Shirakabe, T. Sasamura, P. Speder, S. Noselli, T. Aigaki, R. Murakami, and K. Matsuno. (2006). An unconventional myosin in Drosophila reverses the default handedness in visceral organs. Nature 440, 798–802.

    Article  PubMed  CAS  Google Scholar 

  • Huang, J. D., S. T. Brady, B. W. Richards, D. Stenolen, J. H. Resau, N. G. Copeland, and N. A. Jenkins. (1999). Direct interaction of microtubule- and actin-based transport motors. Nature 397, 267–70.

    Article  PubMed  CAS  Google Scholar 

  • Hwang, K. J., F. Mahmoodian, J. A. Ferretti, E. D. Korn, and J. M. Gruschus. (2007). Intramolecular interaction in the tail of Acanthamoeba myosin IC between the SH3 domain and a putative pleckstrin homology domain. Proc Natl Acad Sci USA 104, 784–9.

    Article  PubMed  CAS  Google Scholar 

  • Ingber, D. E. (2004). The mechanochemical basis of cell and tissue regulation. Mech Chem Biosyst 1, 53–68.

    PubMed  CAS  Google Scholar 

  • Ingber, D. E. (2006). Cellular mechanotransduction: putting all the pieces together again. Faseb J 20, 811–27.

    Article  PubMed  CAS  Google Scholar 

  • Inoue, A., J. Saito, R. Ikebe, and M. Ikebe. (2002). Myosin IXb is a single-headed minus-end-directed processive motor. Nat Cell Biol 4, 302–6.

    Article  PubMed  CAS  Google Scholar 

  • Isogawa, Y., T. Kon, T. Inoue, R. Ohkura, H. Yamakawa, O. Ohara, and K. Sutoh. (2005). The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site. Biochemistry 44, 6190–6.

    Article  PubMed  CAS  Google Scholar 

  • Ivarsson, R., X. Jing, L. Waselle, R. Regazzi, and E. Renstrom. (2005). Myosin 5a controls insulin granule recruitment during late-phase secretion. Traffic 6, 1027–35.

    Article  PubMed  CAS  Google Scholar 

  • Jansen, R. P., C. Dowzer, C. Michaelis, M. Galova, and K. Nasmyth. (1996). Mother cell-specific HO expression in budding yeast depends on the unconventional myosin myo4p and other cytoplasmic proteins. Cell 84, 687–97.

    Article  PubMed  CAS  Google Scholar 

  • Janssen, K. P., and M. Schleicher. (2001). Dictyostelium discoideum: a genetic model system for the study of professional phagocytes. Profilin, phosphoinositides and the lmp gene family in Dictyostelium. Biochim Biophys Acta 1525, 228–33.

    CAS  Google Scholar 

  • Jerdeva, G. V., K. Wu, F. A. Yarber, C. J. Rhodes, D. Kalman, J. E. Schechter, and S. F. Hamm-Alvarez. (2005). Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells. J Cell Sci 118, 4797–812.

    Article  PubMed  CAS  Google Scholar 

  • Jonsdottir, G. A., and R. Li. (2004). Dynamics of yeast Myosin I: evidence for a possible role in scission of endocytic vesicles. Curr Biol 14, 1604–9.

    Article  PubMed  CAS  Google Scholar 

  • Jung, E. J., G. Liu, W. Zhou, and X. Chen. (2006). Myosin VI is a mediator of the p53-dependent cell survival pathway. Mol Cell Biol 26, 2175–86.

    Article  PubMed  CAS  Google Scholar 

  • Kahle, M., J. Pridalova, M. Spacek, R. Dzijak, and P. Hozak. (2007). Nuclear myosin is ubiquitously expressed and evolutionary conserved in vertebrates. Histochem Cell Biol 127, 139–48.

    Article  PubMed  CAS  Google Scholar 

  • Kalhammer, G., M. Bähler, F. Schmitz, J. Jockel, and C. Block. (1997). Ras-binding domains: predicting function versus folding. FEBS Lett 414, 599–602.

    Article  PubMed  CAS  Google Scholar 

  • Kalil, K., and E. W. Dent. (2004). Hot +TIPS: guidance cues signal directly to microtubules. Neuron 42, 877–9.

    Article  PubMed  CAS  Google Scholar 

  • Kalil, K., and E. W. Dent. (2005). Touch and go: guidance cues signal to the growth cone cytoskeleton. Curr Opin Neurobiol 15, 521–6.

    Article  PubMed  CAS  Google Scholar 

  • Kempler, K., J. Toth, R. Yamashita, G. Mapel, K. Robinson, H. Cardasis, S. Stevens, J. R. Sellers, and B. A. Battelle. (2007). Loop 2 of Limulus myosin III Is phosphorylated by protein kinase A and autophosphorylation. Biochemistry 46(14), 4280–4293.

    Article  PubMed  CAS  Google Scholar 

  • Kim, S. V., W. Z. Mehal, X. Dong, V. Heinrich, M. Pypaert, I. Mellman, M. Dembo, M. S. Mooseker, D. Wu, and R. A. Flavell. (2006). Modulation of cell adhesion and motility in the immune system by Myo1f. Science 314, 136–9.

    Article  PubMed  CAS  Google Scholar 

  • Kollmar, M. (2006). Thirteen is enough: the myosins of Dictyostelium discoideum and their light chains. BMC Genomics 7, 183.

    Article  PubMed  Google Scholar 

  • Komaba, S., A. Inoue, S. Maruta, H. Hosoya, and M. Ikebe. (2003). Determination of human myosinIII as a motor protein having a protein kinase activity. J Biol Chem 278, 21352–60.

    Article  PubMed  CAS  Google Scholar 

  • Korn, E. D. (2000). Coevolution of head, neck, and tail domains of myosin heavy chains. Proc Natl Acad Sci USA 97, 12559–64.

    Article  PubMed  CAS  Google Scholar 

  • Krendel, M., and M. S. Mooseker. (2005). Myosins: tails (and heads) of functional diversity. Physiology (Bethesda) 20, 239–51.

    CAS  Google Scholar 

  • Krendel, M., E. K. Osterweil, and M. S. Mooseker. (2007). Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis. FEBS Lett 581, 644–50.

    Article  PubMed  CAS  Google Scholar 

  • Kros, C. J., W. Marcotti, S. M. van Netten, T. J. Self, R. T. Libby, S. D. Brown, G. P. Richardson, and K. P. Steel. (2002). Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations. Nat Neurosci 5, 41–7.

    Article  PubMed  CAS  Google Scholar 

  • Kuroda, T. S., and M. Fukuda. (2005). Identification and biochemical analysis of Slac2-c/MyRIP as a Rab27A-, myosin Va/VIIa-, and actin-binding protein. Methods Enzymol 403, 431–44.

    PubMed  CAS  Google Scholar 

  • Kussel-Andermann, P., A. El-Amraoui, S. Safieddine, J. P. Hardelin, S. Nouaille, J. Camonis, and C. Petit. (2000a). Unconventional myosin VIIA is a novel A-kinase-anchoring protein. J Biol Chem 275, 29654–9.

    Article  CAS  Google Scholar 

  • Kussel-Andermann, P., A. El-Amraoui, S. Safieddine, S. Nouaille, I. Perfettini, M. Lecuit, P. Cossart, U. Wolfrum, and C. Petit. (2000b). Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex. Embo J 19, 6020–9.

    Article  CAS  Google Scholar 

  • Langford, G. M. (2002). Myosin-V, a versatile motor for short-range vesicle transport. Traffic 3, 859–65.

    Article  PubMed  CAS  Google Scholar 

  • Lawrence, C. J., R. K. Dawe, K. R. Christie, D. W. Cleveland, S. C. Dawson, S. A. Endow, L. S. Goldstein, H. V. Goodson, N. Hirokawa, J. Howard, R. L. Malmberg, J. R. McIntosh, H. Miki, T. J. Mitchison, Y. Okada, A. S. Reddy, W. M. Saxton, M. Schliwa, J. M. Scholey, R. D. Vale, C. E. Walczak, and L. Wordeman. (2004). A standardized kinesin nomenclature. J Cell Biol 167, 19–22.

    Article  PubMed  CAS  Google Scholar 

  • Lise, M. F., T. P. Wong, A. Trinh, R. M. Hines, L. Liu, R. Kang, D. J. Hines, J. Lu, J. R. Goldenring, Y. T. Wang, and A. El-Husseini. (2006). Involvement of myosin Vb in glutamate receptor trafficking. J Biol Chem 281, 3669–78.

    Article  PubMed  CAS  Google Scholar 

  • Lister, I., S. Schmitz, M. Walker, J. Trinick, F. Buss, C. Veigel, and J. Kendrick-Jones. (2004). A monomeric myosin VI with a large working stroke. Embo J. 23, 1729–38.

    Article  PubMed  CAS  Google Scholar 

  • Lovy-Wheeler, A., L. Cardenas, J. G. Kunkel, and P. K. Hepler. (2007). Differential organelle movement on the actin cytoskeleton in lily pollen tubes. Cell Motil Cytoskeleton 64, 217–32.

    Article  PubMed  Google Scholar 

  • Mao, Y., C. Rauskolb, E. Cho, W. L. Hu, H. Hayter, G. Minihan, F. N. Katz, and K. D. Irvine. (2006). Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila. Development 133, 2539–51.

    Article  PubMed  CAS  Google Scholar 

  • Matsui, Y. (2003). Polarized distribution of intracellular components by class V myosins in Saccharomyces cerevisiae. Int Rev Cytol 229, 1–42.

    PubMed  CAS  Google Scholar 

  • Mermall, V., N. Bonafe, L. Jones, J. R. Sellers, L. Cooley, and M. S. Mooseker. (2005). Drosophila myosin V is required for larval development and spermatid individualization. Dev Biol 286, 238–55.

    Article  PubMed  CAS  Google Scholar 

  • Montell, C., and G. M. Rubin. (1988). The Drosophila ninaC locus encodes two photoreceptor cell specific proteins with domains homologous to protein kinases and the myosin heavy chain head. Cell 52, 757–72.

    Article  PubMed  CAS  Google Scholar 

  • Morgan, N. S., M. B. Heintzelman, and M. S. Mooseker. (1995). Characterization of myosin-IA and myosin-IB, two unconventional myosins associated with the Drosophila brush border cytoskeleton. Dev Biol 172, 51–71.

    Article  PubMed  CAS  Google Scholar 

  • Morgan, N. S., D. M. Skovronsky, S. Artavanis-Tsakonas, and M. S. Mooseker. (1994). The molecular cloning and characterization of Drosophila melanogaster myosin-IA and myosin-IB. J Mol Biol 239, 347–56.

    Article  PubMed  CAS  Google Scholar 

  • Muller, M., A. Heuck, and D. Niessing. (2007). Directional mRNA transport in eukaryotes: lessons from yeast. Cell Mol Life Sci 64, 171–80.

    Article  PubMed  CAS  Google Scholar 

  • Nalavadi, V., M. Nyitrai, C. Bertolini, N. Adamek, M. A. Geeves, and M. Bähler. (2005). Kinetic mechanism of myosin IXB and the contributions of two class IX-specific regions. J Biol Chem 280, 38957–68.

    Article  PubMed  CAS  Google Scholar 

  • Neco, P., A. Gil, M. Del Mar Frances, S. Viniegra, and L. M. Gutierrez. (2002). The role of myosin in vesicle transport during bovine chromaffin cell secretion. Biochem J 368, 405–13.

    Article  PubMed  CAS  Google Scholar 

  • Neco, P., D. Giner, S. Viniegra, R. Borges, A. Villarroel, and L. M. Gutierrez. (2004). New roles of myosin II during vesicle transport and fusion in chromaffin cells. J Biol Chem 279, 27450–7.

    Article  PubMed  CAS  Google Scholar 

  • Nedvetsky, P. I., E. Stefan, S. Frische, K. Santamaria, B. Wiesner, G. Valenti, J. A. Hammer, 3rd, S. Nielsen, J. R. Goldenring, W. Rosenthal, and E. Klussmann. (2007). A role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle. Traffic 8(2), 110–123.

    Article  PubMed  CAS  Google Scholar 

  • Ng, K. P., T. Kambara, M. Matsuura, M. Burke, and M. Ikebe. (1996). Identification of myosin III as a protein kinase. Biochemistry 35, 9392–9.

    Article  PubMed  CAS  Google Scholar 

  • Nishikawa, M., S. Nishikawa, A. Inoue, A. H. Iwane, T. Yanagida, and M. Ikebe. (2006). A unique mechanism for the processive movement of single-headed myosin-IX. Biochem Biophys Res Commun 343, 1159–64.

    Article  PubMed  CAS  Google Scholar 

  • Norbury, C. C. (2006). Drinking a lot is good for dendritic cells. Immunology 117, 443–51.

    Article  PubMed  CAS  Google Scholar 

  • O’Connell C, B., M. J. Tyska, and M. S. Mooseker. (2007). Myosin at work: Motor adaptations for a variety of cellular functions. Biochim Biophys Acta 1773(5), 615–630.

    Article  PubMed  CAS  Google Scholar 

  • Ohashi, S., K. Koike, A. Omori, S. Ichinose, S. Ohara, S. Kobayashi, T.A. Sato, and K. Anzai. (2002). Identification of mRNA/protein (mRNP) complexes containing Puralpha, mStaufen, fragile X protein, and myosin Va and their association with rough endoplasmic reticulum equipped with a kinesin motor. J Biol Chem 277, 37804–10.

    Article  PubMed  CAS  Google Scholar 

  • Ohyama, A., Y. Komiya, and M. Igarashi. (2001). Globular tail of myosin-V is bound to vamp/synaptobrevin. Biochem Biophys Res Commun 280, 988–91.

    Article  PubMed  CAS  Google Scholar 

  • Ostap, E. M., P. Maupin, S. K. Doberstein, I. C. Baines, E. D. Korn, and T. D. Pollard. (2003). Dynamic localization of myosin-I to endocytic structures in Acanthamoeba. Cell Motil Cytoskeleton 54, 29–40.

    Article  PubMed  CAS  Google Scholar 

  • Osterweil, E., D. G. Wells, and M. S. Mooseker. (2005). A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis. J Cell Biol 168, 329–38.

    Article  PubMed  CAS  Google Scholar 

  • Parker, R., and U. Sheth. (2007). P bodies and the control of mRNA translation and degradation. Mol Cell 25, 635–46.

    Article  PubMed  CAS  Google Scholar 

  • Patel, K. G., C. Liu, P. L. Cameron, and R. S. Cameron. (2001). Myr 8, a novel unconventional myosin expressed during brain development associates with the protein phosphatase catalytic subunits 1alpha and 1gamma1. J Neurosci 21, 7954–68.

    PubMed  CAS  Google Scholar 

  • Percipalle, P., and A. K. Farrants. (2006). Chromatin remodelling and transcription: be-WICHed by nuclear myosin 1. Curr Opin Cell Biol 18, 267–74.

    Article  PubMed  CAS  Google Scholar 

  • Petritsch, C., G. Tavosanis, C. W. Turck, L. Y. Jan, and Y. N. Jan. (2003). The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. Dev Cell 4, 273–81.

    Article  PubMed  CAS  Google Scholar 

  • Pollard, T. D., and E. D. Korn. (1973a). Acanthamoeba myosin. I. Isolation from Acanthamoeba castellani of an enzyme similar to muscle myosin. J Biol Chem 248, 4682–90.

    CAS  Google Scholar 

  • Pollard, T. D., and E. D. Korn. (1973b). Acanthamoeba myosin. II. Interaction with actin and with a new cofactor protein required for actin activation of Mg$2 +$ adenosine triphosphatase activity. J Biol Chem 248, 4691–7.

    CAS  Google Scholar 

  • Pollard, T. D., W. S. Stafford, and M. E. Porter. (1978). Characterization of a second myosin from Acanthamoeba castellani. J Biochem 253 (13), 4798–4808.

    CAS  Google Scholar 

  • Porter, J. A., B. Minke, and C. Montell. (1995). Calmodulin binding to Drosophila NinaC required for termination of phototransduction. Embo J. 14, 4450–9.

    PubMed  CAS  Google Scholar 

  • Porter, J. A., M. Yu, S. K. Doberstein, T. D. Pollard, and C. Montell. (1993). Dependence of calmodulin localization in the retina on the NINAC unconventional myosin. Science 262, 1038–42.

    Article  PubMed  CAS  Google Scholar 

  • Post, P. L., M. J. Tyska, C. B. O’Connell, K. Johung, A. Hayward, and M. S. Mooseker. (2002). Myosin-IXb is a single-headed and processive motor. J Biol Chem 277, 11679–83.

    Article  PubMed  CAS  Google Scholar 

  • Prekeris, R., and D. M. Terrian. (1997). Brain myosin V is a synaptic vesicle-associated motor protein: evidence for a Ca$2 +$-dependent interaction with the synaptobrevin-synaptophysin complex. J Cell Biol 137, 1589–601.

    Article  PubMed  CAS  Google Scholar 

  • Puthalakath, H., A. Villunger, L. A. O’Reilly, J. G. Beaumont, L. Coultas, R. E. Cheney, D. C. Huang, and A. Strasser. (2001). Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science 293, 1829–32.

    Article  PubMed  CAS  Google Scholar 

  • Rao, M. V., L. J. Engle, P. S. Mohan, A. Yuan, D. Qiu, A. Cataldo, L. Hassinger, S. Jacobsen, V. M. Lee, A. Andreadis, J. P. Julien, P. C. Bridgman, and R. A. Nixon. (2002). Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density. J Cell Biol 159, 279–90.

    Article  PubMed  CAS  Google Scholar 

  • Rayment, I., W. R. Rypniewski, K. Schmidt-Base, R. Smith, D.R. Tomchick, M. M. Benning, D. A. Winkelmann, G. Wesenberg, and H. M. Holden. (1993). Three-dimensional structure of myosin subfragment-1: a molecular motor [see comments]. Science 261, 50–8.

    Article  PubMed  CAS  Google Scholar 

  • Reck-Peterson, S. L., D. W. Provance, M. S. Mooseker, and J. A. Mercer. (2000). Class V Myosins. Biochimica et Biophysica Acta 1496, 36–51.

    Google Scholar 

  • Reed, B. C., C. Cefalu, B. H. Bellaire, J. A. Cardelli, T. Louis, J. Salamon, M. A. Bloecher, and R. C. Bunn. (2005). GLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and myosin VI: evidence supporting an adapter function for GLUT1CBP. Mol Biol Cell 16, 4183–201.

    Article  PubMed  CAS  Google Scholar 

  • Reinhard, J., A. A. Scheel, D. Diekmann, A. Hall, C. Ruppert, and M. Bähler. (1995). A novel type of myosin implicated in signalling by rho family GTPases. Embo J 14, 697–704.

    PubMed  CAS  Google Scholar 

  • Rey, M., A. Valenzuela-Fernàndez, A. Urzainqui, M. Yànez-Mò, M. Pèrez-Martìnez, P. Penela, F. Mayor, Jr., and F. Sànchez-Madrid. (2007). Myosin IIA is involved in the endocytosis of CXCR4 induced by SDF-1α. J Cell Sci 120, 1126–33.

    Article  PubMed  CAS  Google Scholar 

  • Richards, T.A., and T. Cavalier-Smith. (2005). Myosin domain evolution and the primary divergence of eukaryotes. Nature 436, 1113–8.

    Article  PubMed  CAS  Google Scholar 

  • Rodriguez, O. C., A. W. Schaefer, C. A. Mandato, P. Forscher, W. M. Bement, and C. M. Waterman-Storer. (2003). Conserved microtubule-actin interactions in cell movement and morphogenesis. Nat Cell Biol 5, 599–609.

    Article  PubMed  CAS  Google Scholar 

  • Rose, S. D., T. Lejen, L. Casaletti, R. E. Larson, T. D. Pene, and J. M. Trifaro. (2003). Myosins II and V in chromaffin cells: myosin V is a chromaffin vesicle molecular motor involved in secretion. J Neurochem 85, 287–98.

    PubMed  CAS  Google Scholar 

  • Rudolf, R., T. Kogel, S. A. Kuznetsov, T. Salm, O. Schlicker, A. Hellwig, J. A. Hammer, 3rd, and H. H. Gerdes. (2003). Myosin Va facilitates the distribution of secretory granules in the F-actin rich cortex of PC12 cells. J Cell Sci 116, 1339–48.

    Article  PubMed  CAS  Google Scholar 

  • Sahlender, D. A., R. C. Roberts, S. D. Arden, G. Spudich, M. J. Taylor, J. P. Luzio, J. Kendrick-Jones, and F. Buss. (2005). Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis. J Cell Biol 169, 285–95.

    Article  PubMed  CAS  Google Scholar 

  • Schmid, M., A. Jaedicke, T. G. Du, and R. P. Jansen. (2006). Coordination of endoplasmic reticulum and mRNA localization to the yeast bud. Curr Biol 16, 1538–43.

    Article  PubMed  CAS  Google Scholar 

  • Shepard, K. A., A. P. Gerber, A. Jambhekar, P. A. Takizawa, P. O. Brown, D. Herschlag, J. L. DeRisi, and R. D. Vale. (2003). Widespread cytoplasmic mRNA transport in yeast: identification of 22 bud-localized transcripts using DNA microarray analysis. Proc Natl Acad Sci USA 100, 11429–34.

    Article  PubMed  CAS  Google Scholar 

  • Simon, J. P., T. H. Shen, I. E. Ivanov, D. Gravotta, T. Morimoto, M. Adesnik, and D. D. Sabatini. (1998). Coatomer, but not P200/myosin II, is required for the in vitro formation of trans-Golgi network-derived vesicles containing the envelope glycoprotein of vesicular stomatitis virus. Proc Natl Acad Sci USA 95, 1073–8.

    Article  PubMed  CAS  Google Scholar 

  • Sokac, A. M., C. Schietroma, C. B. Gundersen, and W. M. Bement. (2006). Myosin-1c couples assembling actin to membranes to drive compensatory endocytosis. Dev Cell 11, 629–40.

    Article  PubMed  CAS  Google Scholar 

  • Soni, L. E., C. M. Warren, C. Bucci, D. J. Orten, and T. Hasson. (2005). The unconventional myosin-VIIa associates with lysosomes. Cell Motil Cytoskeleton 62, 13–26.

    Article  PubMed  CAS  Google Scholar 

  • Sotelo-Silveira, J. R., A. Calliari, M. Cardenas, E. Koenig, and J. R. Sotelo. (2004). Myosin Va and kinesin II motor proteins are concentrated in ribosomal domains (periaxoplasmic ribosomal plaques) of myelinated axons. J Neurobiol 60, 187–96.

    Article  PubMed  CAS  Google Scholar 

  • Sotelo-Silveira, J. R., A. Calliari, A. Kun, E. Koenig, and J. R. Sotelo. (2006). RNA trafficking in axons. Traffic 7, 508–15.

    Article  PubMed  CAS  Google Scholar 

  • Speder, P., G. Adam, and S. Noselli. (2006). Type ID unconventional myosin controls left-right asymmetry in Drosophila. Nature 440, 803–7.

    Article  PubMed  CAS  Google Scholar 

  • Speder, P., and S. Noselli. (2007). Left-right asymmetry: class I myosins show the direction. Curr Opin Cell Biol 19(1), 82–87.

    Article  PubMed  CAS  Google Scholar 

  • Stöffler, H. E., and M. Bähler. (1998). The ATPase activity of Myr3, a rat myosin I, is allosterically inhibited by its own tail domain and by Ca$2 +$ binding to its light chain calmodulin. J Biol Chem 273, 14605–11.

    Article  PubMed  Google Scholar 

  • Stow, J. L., K. R. Fath, and D. R. Burgess. (1998). Budding roles for myosin II on the Golgi. Trends Cell Biol 8, 138–41.

    Article  PubMed  CAS  Google Scholar 

  • Sun, Y., A. C. Martin, and D. G. Drubin. (2006). Endocytic internalization in budding yeast requires coordinated actin nucleation and myosin motor activity. Dev Cell 11, 33–46.

    Article  PubMed  CAS  Google Scholar 

  • Swanson, J. A., M. T. Johnson, K. Beningo, P. Post, M. Mooseker, and N. Araki. (1999). A contractile activity that closes phagosomes in macrophages. J Cell Sci 112 (Pt 3), 307–16.

    PubMed  CAS  Google Scholar 

  • Sweeney, H. L., and A. Houdusse. (2007). What can myosin VI do in cells? Curr Opin Cell Biol 19(1), 57–66.

    Article  PubMed  CAS  Google Scholar 

  • Swiatecka-Urban, A., C. Boyd, B. Coutermarsh, K. H. Karlson, R. Barnaby, L. Aschenbrenner, G. M. Langford, T. Hasson, and B.A. Stanton. (2004). Myosin VI regulates endocytosis of the cystic fibrosis transmembrane conductance regulator. J Biol Chem 279, 38025–31.

    Article  PubMed  CAS  Google Scholar 

  • Takagishi, Y., S. Oda, S. Hayasaka, K. Dekker-Ohno, T. Shikata, M. Inouye, and H. Yamamura. (1996). The dilute-lethal (dl) gene attacks a Ca$2 +$ store in the dendritic spine of Purkinje cells in mice. Neurosci Lett 215, 169–72.

    PubMed  CAS  Google Scholar 

  • Takizawa, P. A., A. Sil, J. R. Swedlow, I. Herskowitz, and R. D. Vale. (1997). Actin-dependent localization of an RNA encoding a cell-fate determinant in yeast. Nature 389, 90–3.

    Article  PubMed  CAS  Google Scholar 

  • Thompson, R. F., and G. M. Langford. (2002). Myosin superfamily evolutionary history. Anat Rec 268, 276–89.

    Article  PubMed  CAS  Google Scholar 

  • Titus, M. A. (1999). A class VII unconventional myosin is required for phagocytosis. Curr Biol 9, 1297–303.

    Article  PubMed  CAS  Google Scholar 

  • Titus, M. A. (2000). The role of unconventional myosins in Dictyostelium endocytosis. J Eukaryot Microbiol 47, 191–6.

    Article  PubMed  CAS  Google Scholar 

  • Titus, M. A. (2005a). A conserved role for myosin VII in adhesion. Novartis Found Symp 269, 16–24; discussion 24–34, 223–30.

    Article  CAS  Google Scholar 

  • Titus, M. A. (2005b). Evolution: a treasure trove of motors. Nature 436, 1097–9.

    Article  CAS  Google Scholar 

  • Togo, T., and R. A. Steinhardt. (2004). Nonmuscle myosin IIA and IIB have distinct functions in the exocytosis-dependent process of cell membrane repair. Mol Biol Cell 15, 688–95.

    Article  PubMed  CAS  Google Scholar 

  • Tyska, M. J., A. T. Mackey, J. D. Huang, N. G. Copeland, N. A. Jenkins, and M. S. Mooseker. (2005). Myosin-1a is critical for normal brush border structure and composition. Mol Biol Cell 16, 2443–57.

    Article  PubMed  CAS  Google Scholar 

  • Tyska, M. J., and M. S. Mooseker. (2002). MYO1A (brush border myosin I) dynamics in the brush border of LLC-PK1-CL4 cells. Biophys J 82, 1869–83.

    Article  PubMed  CAS  Google Scholar 

  • Tyska, M. J., and M. S. Mooseker. (2004). A role for myosin-1A in the localization of a brush border disaccharidase. J Cell Biol 165, 395–405.

    Article  PubMed  CAS  Google Scholar 

  • van Duffelen, M., L. R. Chrin, and C. L. Berger. (2005). Kinetics of structural changes in the relay loop and SH3 domain of myosin. Biochem Biophys Res Commun 329, 563–72.

    Article  PubMed  CAS  Google Scholar 

  • Varadi, A., T. Tsuboi, and G. A. Rutter. (2005). Myosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cells. Mol Biol Cell 16, 2670–80.

    Article  PubMed  CAS  Google Scholar 

  • Velichkova, M., J. Guttman, C. Warren, L. Eng, K. Kline, A. W. Vogl, and T. Hasson. (2002). A human homologue of Drosophila kelch associates with myosin-VIIa in specialized adhesion junctions. Cell Motil Cytoskeleton 51, 147–64.

    Article  PubMed  CAS  Google Scholar 

  • Villace, P., R. M. Marion, and J. Ortin. (2004). The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs. Nucleic Acids Res 32, 2411–20.

    Article  PubMed  CAS  Google Scholar 

  • Vreugde, S., C. Ferrai, A. Miluzio, E. Hauben, P. C. Marchisio, M. P. Crippa, M. Bussi, and S. Biffo. (2006). Nuclear myosin VI enhances RNA polymerase II-dependent transcription. Mol Cell 23, 749–55.

    Article  PubMed  CAS  Google Scholar 

  • Wagner, M. C., B. L. Blazer-Yost, J. Boyd-White, A. Srirangam, J. Pennington, and S. Bennett. (2005). Expression of the unconventional myosin Myo1c alters sodium transport in M1 collecting duct cells. Am J Physiol Cell Physiol 289, C120–9.

    Article  PubMed  CAS  Google Scholar 

  • Wang, F. S., J. S. Wolenski, R. E. Cheney, M. S. Mooseker, and D. G. Jay. (1996). Function of myosin-V in filopodial extension of neuronal growth cones. Science 273, 660–3.

    Article  PubMed  CAS  Google Scholar 

  • Wang, Q., M. A. Deloia, Y. Kang, C. Litchke, N. Zhang, M. A. Titus, and K. J. Walters. (2007). The SH3 domain of a M7 interacts with its C-terminal proline-rich region. Protein Sci 16(2):189–196.

    Article  PubMed  CAS  Google Scholar 

  • Warner, C. L., A. Stewart, J. P. Luzio, K. P. Steel, R. T. Libby, J. Kendrick-Jones, and F. Buss. (2003). Loss of myosin VI reduces secretion and the size of the Golgi in fibroblasts from Snell’s waltzer mice. Embo J 22, 569–79.

    Article  PubMed  CAS  Google Scholar 

  • Watanabe, M., K. Nomura, A. Ohyama, R. Ishikawa, Y. Komiya, K. Hosaka, E. Yamauchi, H. Taniguchi, N. Sasakawa, K. Kumakura, T. Ushiki, O. Sato, M. Ikebe, and M. Igarashi. (2005). Myosin-Va regulates exocytosis through the submicromolar Ca$2 +$-dependent binding of syntaxin-1A. Mol Biol Cell 16, 4519–30.

    Article  PubMed  CAS  Google Scholar 

  • Weber, K. L., A. M. Sokac, J. S. Berg, R. E. Cheney, and W. M. Bement. (2004). A microtubule-binding myosin required for nuclear anchoring and spindle assembly. Nature 431, 325–9.

    Article  PubMed  CAS  Google Scholar 

  • Weiss, I. M., V. Schonitzer, N. Eichner, and M. Sumper. (2006). The chitin synthase involved in marine bivalve mollusk shell formation contains a myosin domain. FEBS Lett 580, 1846–52.

    Article  PubMed  CAS  Google Scholar 

  • Wirth, J. A., K. A. Jensen, P. L. Post, W. M. Bement, and M. S. Mooseker. (1996). Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail. J Cell Sci. 109 (Pt 3), 653–61.

    PubMed  CAS  Google Scholar 

  • Wu, X., X. Xiang, and J. A. Hammer, 3rd. (2006). Motor proteins at the microtubule plus-end. Trends Cell Biol 16, 135–43.

    Article  PubMed  CAS  Google Scholar 

  • Yang, C., M. Pring, M. A. Wear, M. Huang, J. A. Cooper, T. M. Svitkina, and S. H. Zigmond. (2005). Mammalian CARMIL inhibits actin filament capping by capping protein. Dev Cell 9, 209–21.

    Article  PubMed  CAS  Google Scholar 

  • Yokota, E., C. Yukawa, S. Muto, S. Sonobe, and T. Shimmen. (1999). Biochemical and immunocytochemical characterization of two types of myosins in cultured tobacco bright yellow-2 cells. Plant Physiol 121, 525–34.

    Article  PubMed  CAS  Google Scholar 

  • Yoshida, H., W. Cheng, J. Hung, D. Montell, E. Geisbrecht, D. Rosen, J. Liu, and H. Naora. (2004). Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer. Proc Natl Acad Sci USA 101, 8144–9.

    Article  PubMed  CAS  Google Scholar 

  • Yoshimura, A., R. Fujii, Y. Watanabe, S. Okabe, K. Fukui, and T. Takumi. (2006). Myosin-Va facilitates the accumulation of mRNA/protein complex in dendritic spines. Curr Biol 16, 2345–51.

    Article  PubMed  CAS  Google Scholar 

  • Zhang, H., J. S. Berg, Z. Li, Y. Wang, P. Lang, A. D. Sousa, A. Bhaskar, R. E. Cheney, and S. Stromblad. (2004). Myosin-X provides a motor-based link between integrins and the cytoskeleton. Nat Cell Biol 6, 523–31.

    Article  PubMed  CAS  Google Scholar 

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Mooseker, M.S., Foth, B.J. (2008). The Structural And Functional Diversity Of The Myosin Family Of Actin-Based Molecular Motors. In: Myosins. Proteins and Cell Regulation, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6519-4_1

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