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Basics of the Cytoskeleton: Myosins

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Cytoskeleton and Human Disease

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Abstract

The myosin superfamily of molecular motors plays essential roles in a wide variety of cellular processes by virtue of their ability to generate force and motion through an ATP-driven cyclic interaction with actin filaments. We provide an overview of the structure, function, and biophysical properties that are common to most characterized myosins and also include examples of how myosins are adapted to perform specific cellular functions. Since many myosins are implicated in disease conditions, a complete understanding of their cellular roles and biophysical properties is critical for developing treatments for these diseases.

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Authors and Affiliations

  1. Department of Cellular and Molecular Physiology, The Penn State College of Medicine, 500 University Dr, 17033, Hershey, PA, USA

    Christopher M. Yengo

  2. Department of Biology, University of North Carolina Charlotte, 28223, Charlotte, NC, USA

    Judy E. Moore

  3. Department of Biology, University of Richmond, 23173, Richmond, VA, USA

    Omar A. Quintero

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  1. Omar A. Quintero
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  2. Judy E. Moore
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  3. Christopher M. Yengo
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Correspondence to Christopher M. Yengo .

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  1. Australia for Medical Research, Iron Metabolism Program, Children's Cancer Institute, Randwick, New South Wales, Australia

    Maria Kavallaris

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Quintero, O.A., Moore, J.E., Yengo, C.M. (2012). Basics of the Cytoskeleton: Myosins. In: Kavallaris, M. (eds) Cytoskeleton and Human Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-788-0_4

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