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Cholera Dynamics and the Emergence of Pandemic Vibrio cholerae

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Vibrio spp. Infections

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1404))

Abstract

Cholera is a severe diarrheal disease caused by the aquatic bacterium Vibrio cholerae. Interestingly, to date, only one major clade has emerged to cause pandemic disease in humans: the clade that encompasses the strains from the O1 and O139 serogroups. In this chapter, we provide a comprehensive perspective on the virulence factors and mobile genetic elements (MGEs) associated with the emergence of pandemic V. cholerae strains and highlight novel findings such as specific genomic background or interactions between MGEs that explain their confined distribution. Finally, we discuss pandemic cholera dynamics contextualizing them within the evolution of the bacterium.

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Acknowledgments

This work was supported by a National Science Foundation CAREER award (#2045671) and a Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Disease award (#1021977) to S.A.M.

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Authors and Affiliations

  1. Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA

    Deepak Balasubramanian, Mario López-Pérez & Salvador Almagro-Moreno

  2. National Center for Integrated Coastal Research, University of Central Florida, Orlando, FL, USA

    Deepak Balasubramanian, Mario López-Pérez & Salvador Almagro-Moreno

  3. Evolutionary Genomics Group, División de Microbiología, Universidad Miguel Hernández, Alicante, Spain

    Mario López-Pérez

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  1. Deepak Balasubramanian
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  2. Mario López-Pérez
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  3. Salvador Almagro-Moreno
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Correspondence to Salvador Almagro-Moreno .

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  1. Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, USA

    Salvador Almagro-Moreno

  2. Department of Biology, The City College of New York, New York, NY, USA

    Stefan Pukatzki

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Balasubramanian, D., López-Pérez, M., Almagro-Moreno, S. (2023). Cholera Dynamics and the Emergence of Pandemic Vibrio cholerae. In: Almagro-Moreno, S., Pukatzki, S. (eds) Vibrio spp. Infections. Advances in Experimental Medicine and Biology, vol 1404. Springer, Cham. https://doi.org/10.1007/978-3-031-22997-8_7

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