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Nuclear Molecular Motors for Active, Directed Chromatin Movement in Interphase Nuclei

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Advances in Nuclear Architecture

Abstract

The nucleus is a highly organised organelle that contains structural elements which interact and control the genome. A few studies have started to undercover a role for actin and myosin isoforms, found in the nucleus, as nuclear motors that actively move individual gene loci, clusters of genes and whole chromosomes within the nucleoplasm. This chapter reviews these few studies, discusses the presence of proteins potentially part of acto-myosin nuclear motors and asks where these studies should aim to head in the future.

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Acknowledgements

We would like to thank the Brunel University Progeria Research Fund for partially funding ISM in her Ph.D. studies.

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Authors and Affiliations

  1. Laboratory of Nuclear and Genomic Health, Centre for Cell and Chromosome Biology, School of Health Sciences and Social Care, Brunel University, Uxbridge, UB8 3PH, London

    Joanna M. Bridger & Ishita S. Mehta

  2. DNA Repair, Recombination and Replication Laboratory, Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, 400 005, Colaba, Mumbai, India

    Ishita S. Mehta

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  1. Joanna M. Bridger
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  2. Ishita S. Mehta
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Correspondence to Joanna M. Bridger .

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  1. Department of Mathematics, Imperial College, Queen's Gate 180, London, SW7 2AZ, United Kingdom

    Niall M. Adams

  2. Div. Molecular Biosciences, Imperial College London, London, SW7 2AZ, United Kingdom

    Paul S. Freemont

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Bridger, J.M., Mehta, I.S. (2011). Nuclear Molecular Motors for Active, Directed Chromatin Movement in Interphase Nuclei. In: Adams, N., Freemont, P. (eds) Advances in Nuclear Architecture. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9899-3_5

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