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Study of GOLPH3: a Potential Stress-Inducible Protein from Golgi Apparatus

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Abstract

Although the Golgi apparatus has been studied extensively for over 100 years, the complex structure-function relationships have yet to be elucidated. It is well known that the Golgi complex plays an important role in the transport, processing, sorting, and targeting of numerous proteins and lipids destined for secretion, plasma membrane, and lysosomes. Increasing evidence suggests that the Golgi apparatus is a sensor and common downstream effector of stress signals in cell death pathways. It undergoes disassembly and fragmentation in several neurological disorders. Recent studies indicate that Golgi phosphoprotein 3 (GOLPH3 also known as GPP34/GMx33/MIDAS), a peripheral membrane protein of trans-Golgi network, represents an exciting new class of oncoproteins involved in cell signal transduction and is potentially mobilized by stress. In this review, we focus on the importance of GOLPH3 in vesicular trafficking, Golgi architecture maintenance, receptor sorting, protein glycosylation, and further discuss its potential in signal sensing in stress response.

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Abbreviations

ALS:

Amyotrophic lateral sclerosis

Arf1-GTP:

Small GTPase ADP-ribosylation factor 1

cAMP:

Cyclic adenosine monophosphate

CAZy:

Carbohydrate Active Enzymes database

CERT:

Ceramide transporter

CI-MPR:

Cation-independent mannose-6-phosphate

CMT2B:

Charcot-Marie-Tooth Type 2B

COPI:

Coat protein complex I

CPEO:

Chronic progressive external ophthalmoplegia

CyD:

Cytochalasin D

EGFR:

Epidermal growth factor receptor

EXT:

Exostosin

FAPP:

Four-phosphate-adaptor protein

FRAP:

Fluorescence recovery after photo-bleaching

GET1/GET2:

Golgi ER trafficking complex 1/2

GIT:

G-protein coupled receptor kinase interactor

GM130:

Golgi matrix 130

GOLPH3:

Golgi phosphoprotein 3

GRASP65:

Golgi reassembly and stacking protein 65

GT:

Glycosyltransferase

LtB:

Latrunculin B

MELAS:

Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes

MIDAS:

Mitochondrial DNA absence sensitive factor

MRCK:

Myotonic dystrophy kinase-related Cdc4-binding kinase

MTOC:

Microtubule-organizing center

mTOR:

Mammalian target of rapamycin

OSBP:

OxySterol binding protein

PAK2:

p21-activated kinase 2

PI4P:

Phosphatidylinositol 4-phosphate

PI4K:

Phosphatidylinositol 4 kinase

PIX:

p21-activated kinase-interacting exchange factor

Rab 7:

Small GTP-binding protein 7

RIC1/YPT6:

Small GTPase complex 1

RLC:

Myosin regulatory light chain

ROS:

Reactive oxygen species

RTK:

Receptor tyrosine kinase

t-SNARE:

Target-membrane-associated soluble N-ethylmaleimide fusion protein attachment protein receptor

SNX:

Sorting nexin accessory proteins

S6K:

p70 ribosomal S6 kinase

TGN:

Trans-Golgi network

TSC:

Tuberosis sclerosis complex

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Acknowledgments

This work was supported by the National Natural Science Foundation (grant 81171239) and National Natural Science Foundation for Young (no. 81301121) China P.R.

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Authors and Affiliations

  1. Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011, People’s Republic of China

    Ting Li, Hong You, Jie Zhang, Yang Chen, Xiangqi Tang, Zheng Jiang, Ranran Tu, Liuwang Zeng, Wei Lu & Zhiping Hu

  2. Department of Emergency, Xiangya Hospital, Central South University, Changsha, 410011, People’s Republic of China

    Xiaoye Mo

  3. Department of Intensive Care Unit, The Second Xiangya Hospital, Central South University, Changsha, 410011, People’s Republic of China

    Wenfang He

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  1. Ting Li
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  2. Hong You
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  3. Jie Zhang
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  10. Liuwang Zeng
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  11. Wei Lu
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Correspondence to Wei Lu or Zhiping Hu.

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Ting Li and Hong You are co-first author.

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Li, T., You, H., Zhang, J. et al. Study of GOLPH3: a Potential Stress-Inducible Protein from Golgi Apparatus. Mol Neurobiol 49, 1449–1459 (2014). https://doi.org/10.1007/s12035-013-8624-2

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  • DOI: https://doi.org/10.1007/s12035-013-8624-2

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