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Myosin18B predicts favorable prognosis of cutaneous squamous-cell carcinoma

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Abstract

Background

Myosin18 family, including Myosin18A (MYO18A) and Myosin18B (MYO18B), are newly-identified Myosins in Myosin superfamily. The expression and function of Myosin18 family in cancer progression is still controversial, and in cutaneous squamous-cell carcinoma (cSCC) is totally unknown.

Objective

To investigate the expression and prognostic significance of Myosin18 family in cSCC.

Methods

In this study, the expressions of MYO18 family, including MYO18A and MYO18B were detected in six pairs of cSCCs and corresponding normal tissues with qRT-PCR. MYO18A and MYO18B expressions and intracellular locations in 80 cSCCs were detected with immunohistochemistry. The clinical significance was evaluated by analyzing the correlation between MYO18 family and clinicopathological factors. The prognostic significance of MYO18 family was estimated by univariate analysis with log-rank test, and by multivariate analysis by Cox-regression model.

Results

The percentages of high MYO18A and MYO18B in cSCC were 43.75% and 36.25%, respectively. High expression of MYO18A (P = 0.035) and MYO18B (P = 0.032) were both associated with less tumor size. MYO18A had no significant influence on sSCC prognosis (P = 0.686), but low expression of MYO18B was proved to be significantly associated with poor outcome of cSCC (P = 0.014). MYO18B was confirmed as an independent prognostic biomarker of cSCC (P = 0.002), indicating the favorable outcome.

Conclusion

The expression of MYO18B was an independent prognostic biomarker of cSCC, predicting the favorable prognosis independently. Investigating the expression of MYO18B can help stratify the subset of high-risk cSCC patients for more potent treatment and post-operational surveillance.

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Authors and Affiliations

  1. Departments of Dermatology, the Second Affiliated Hospital of Shandong First Medical University, Taian, 271000, Shandong, China

    Can Cao, Chao Zhang, Ying Sun & Zhen Mu

  2. Department of Dermatology, Hubei Provincial Hospital of Traditional Chinese Medicine, No.856, Luoyu Road, Hongshan District, Wuhan, 430061, Hubei, China

    Qin Shen

  3. Department of Dermatology, Hubei Provincial Academy of Traditional Chinese Medicine, Wuhan, 430061, Hubei, China

    Qin Shen

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  1. Can Cao
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  2. Chao Zhang
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  3. Ying Sun
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  4. Zhen Mu
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  5. Qin Shen
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Correspondence to Qin Shen.

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Author Can Cao, author Chao Zhang, author Ying Sun, author Zhen Mu, author Qin Shen declare that they have no conflict of interest.

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Ethics Committee of the Second Hospital of Shandong First Medical University, and the Hubei Provincial Hospital of Traditional Chinese Medicine.

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Cao, C., Zhang, C., Sun, Y. et al. Myosin18B predicts favorable prognosis of cutaneous squamous-cell carcinoma. Genes Genom 43, 371–378 (2021). https://doi.org/10.1007/s13258-021-01037-8

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  • DOI: https://doi.org/10.1007/s13258-021-01037-8

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