ACS Publications. Most Trusted. Most Cited. Most Read

OR SEARCH CITATIONS

My Activity
Publications
CONTENT TYPES

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:Environ. Sci. Technol. 2016, 50, 10, 5346-5356
RETURN TO ISSUEPREVArticleNEXT

Determination of Environmental Exposure to Microcystin and Aflatoxin as a Risk for Renal Function Based on 5493 Rural People in Southwest China

View Author Information
‡ †Department of Tropical Epidemiology, College of Preventive Medicine, ‡Department of Environmental Hygiene, College of Preventive Medicine, §Department of Health Education, College of Preventive Medicine, ∥Department of Transfusion Medicine, Southwest Hospital, and ⊥Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing, 400038 China
# The Center for Disease Control and Prevention in Fuling District, Chongqing, 408000 China
∇ College of Life Science and Engineering, Chongqing Three Gorges University, Wanzhou, Chongqing, 404100 China
○ Township Central Hospital in Yihe Town, Fuling District, Chongqing, 408104 China
◆ Community Health Service Center in Lidu Town, Fuling District, Chongqing, 408103 China
*Telephone: 86-23-68772309; e-mail: [email protected]
Cite this: Environ. Sci. Technol. 2016, 50, 10, 5346–5356
Publication Date (Web):April 12, 2016
https://doi.org/10.1021/acs.est.6b01062
Copyright © 2016 American Chemical Society
Request reuse permissions

    Article Views

    1096

    Altmetric

    -

    Citations

    67
    LEARN ABOUT THESE METRICS
    Other access options
    Get e-Alerts
    SUBJECTS:

    Abstract

    Abstract Image

    Although the nephrotoxicity of microcystin and aflatoxin has been observed in animal and clinical cases, few population data are available. We conducted a cross-sectional study in Southwest China to investigate the association of renal function indicators (RFIs, including BUN, SCr, and eGFR) with exposure to microcystin and aflatoxin in 5493 members of the general population. Microcystin-LR levels in water and aquatic products and aflatoxin B1 levels in daily foods were measured by ELISA, and individual estimated daily intake (EDI) was assessed on the basis of the measurement and questionnaire. We found that participants with abnormal RFIs had a much higher mean level of microcystin-LR EDI than those with normal RFIs and that there was a significant increasing trend for abnormal rates and odds ratios of RFIs with increasing microcystin-LR EDI quartiles (p for trend = 0.000). Compared with the lowest quartile of microcystin-LR exposure, those in the highest quartile had significantly higher risks of abnormal BUN (OR = 1.80, 95% CI = 1.34–2.42), SCr (OR = 4.58, 95% CI = 2.92–7.21), and eGFR (OR = 4.41, 95% CI = 2.55–7.63), respectively, but no higher risk was found in subjects with higher AFB1 exposure. After adjustment for confounding factors, risk associations with microcystin-LR persisted. Consequently, our results suggest that microcystin, rather than aflatoxin, might be one important risk of renal-function impairment.

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. You can change your affiliated institution below.

    Cited By

    This article is cited by 67 publications.

    1. Shuidong Feng, Shuxiang Deng, Yan Tang, Ying Liu, Yue Yang, Shuaishuai Xu, Peng Tang, Yao Lu, Yanying Duan, Jia Wei, Geyu Liang, Yuepu Pu, Xiang Chen, Minxue Shen, Fei Yang. Microcystin-LR Combined with Cadmium Exposures and the Risk of Chronic Kidney Disease: A Case–Control Study in Central China. Environmental Science & Technology 2022, 56 (22) , 15818-15827. https://doi.org/10.1021/acs.est.2c02287
    2. Jun He, Jun Chen, Feng Chen, Liang Chen, John P. Giesy, Yuming Guo, Gaodao Liang, Xuwei Deng, Wenjing Wang, Ping Xie. Health Risks of Chronic Exposure to Small Doses of Microcystins: An Integrative Metabolomic and Biochemical Study of Human Serum. Environmental Science & Technology 2022, 56 (10) , 6548-6559. https://doi.org/10.1021/acs.est.2c00973
    3. Xiaodi Duan, Toby Sanan, Armah de la Cruz, Xuexiang He, Minghao Kong, Dionysios D. Dionysiou. Susceptibility of the Algal Toxin Microcystin-LR to UV/Chlorine Process: Comparison with Chlorination. Environmental Science & Technology 2018, 52 (15) , 8252-8262. https://doi.org/10.1021/acs.est.8b00034
    4. Wenyi Liu, Lingqiao Wang, Xiaohong Yang, Hui Zeng, Renping Zhang, Chaowen Pu, Chuanfen Zheng, Yao Tan, Yang Luo, Xiaobin Feng, Yingqiao Tian, Guosheng Xiao, Jia Wang, Yujing Huang, Jiaohua Luo, Lei Feng, Feng Wang, Changyou Yuan, Yuan Yao, Zhiqun Qiu, Ji-an Chen, Liping Wu, Qingqing Nong, Hui Lin, and Weiqun Shu . Environmental Microcystin Exposure Increases Liver Injury Risk Induced by Hepatitis B Virus Combined with Aflatoxin: A Cross-Sectional Study in Southwest China. Environmental Science & Technology 2017, 51 (11) , 6367-6378. https://doi.org/10.1021/acs.est.6b05404
    5. Liang Chen, Yufei Hu, Jun He, Jun Chen, John P. Giesy, and Ping Xie . Responses of the Proteome and Metabolome in Livers of Zebrafish Exposed Chronically to Environmentally Relevant Concentrations of Microcystin-LR. Environmental Science & Technology 2017, 51 (1) , 596-607. https://doi.org/10.1021/acs.est.6b03990
    6. Damjana Drobac Backović, Nada Tokodi. Cyanotoxins in food: Exposure assessment and health impact. Food Research International 2024, 184 , 114271. https://doi.org/10.1016/j.foodres.2024.114271
    7. Ebenezer Ofori-Attah, Mai Hashimoto, Mayu Oki, Daisuke Kadowaki. Therapeutic Effect of Natural Products and Dietary Supplements on Aflatoxin-Induced Nephropathy. International Journal of Molecular Sciences 2024, 25 (5) , 2849. https://doi.org/10.3390/ijms25052849
    8. Shang-Chun Li, Li-Hong Gu, Yan-Fang Wang, Li-Mei Wang, Liang Chen, John P. Giesy, Xun Tuo, Wen-Li Xu, Qian-Hui Wu, Yi-Qing Liu, Ming-Huo Wu, Yang-Yang Diao, Hao-Hang Zeng, Qing-Bi Zhang. A proteomic study on gastric impairment in rats caused by microcystin-LR. Science of The Total Environment 2024, 917 , 169306. https://doi.org/10.1016/j.scitotenv.2023.169306
    9. XiaoDie ZHOU, Yue YANG, ShuiDong FENG, Fei YANG. Research progress on intestinal toxicity of microcystins. SCIENTIA SINICA Vitae 2023, 24 https://doi.org/10.1360/SSV-2023-0106
    10. Yingzheng Wang, Pawat Pattarawat, Jiyang Zhang, Eunchong Kim, Delong Zhang, Mingzhu Fang, Elizabeth A. Jannaman, Ye Yuan, Saurabh Chatterjee, Ji-Yong Julie Kim, Geoffrey I. Scott, Qiang Zhang, Shuo Xiao. Effects of Cyanobacterial Harmful Algal Bloom Toxin Microcystin-LR on Gonadotropin-Dependent Ovarian Follicle Maturation and Ovulation in Mice. Environmental Health Perspectives 2023, 131 (6) https://doi.org/10.1289/EHP12034
    11. Xueqiong Yao, Ying Liu, Yue Yang, Yafang Li, Na Hu, Fengmei Song, Fei Yang. Microcystin-LR-Exposure-Induced Kidney Damage by Inhibiting MKK6-Mediated Mitophagy in Mice. Toxins 2023, 15 (6) , 404. https://doi.org/10.3390/toxins15060404
    12. Xing Zhang, Xiaojiao Luo, Wei Huang, Bingyuan Tan, Pengfei Hu, Zhiqiang Xia, G. Douglas Haffner, William D. Taylor, Lianghong Long, Daobin Ji, Yan Zhang, Lei. Zhang. Unique physical processes of canyon reservoirs regulate the timing and size of algal blooms - based on a study in Three Gorges Reservoir. Journal of Hydrology 2023, 621 , 129662. https://doi.org/10.1016/j.jhydrol.2023.129662
    13. Zongxin Zhang, Xingde Du, Shiyu Zhang, Haohao Liu, Yu Fu, Fufang Wang, Huizhen Zhang. Adverse effects of microcystins on sperm: A systematic review. Toxicology 2023, 490 , 153507. https://doi.org/10.1016/j.tox.2023.153507
    14. Saurabh Chatterjee, Madhura More. Cyanobacterial Harmful Algal Bloom Toxin Microcystin and Increased Vibrio Occurrence as Climate-Change-Induced Biological Co-Stressors: Exposure and Disease Outcomes via Their Interaction with Gut–Liver–Brain Axis. Toxins 2023, 15 (4) , 289. https://doi.org/10.3390/toxins15040289
    15. Hong Gao, Na Zhu, Shuxiang Deng, Can Du, Yan Tang, Peng Tang, Shuaishuai Xu, Wenya Liu, Minxue Shen, Xinhua Xiao, Fei Yang. Combination Effect of Microcystins and Arsenic Exposures on CKD: A Case-Control Study in China. Toxins 2023, 15 (2) , 144. https://doi.org/10.3390/toxins15020144
    16. Ying Lin, Rongjing An, Chunli Wu, Huixia Liu, Jing Deng, Hongzhuan Tan, Lizhang Chen, Mengshi Chen, Shujuan Ma. Serum microcystin-LR levels and risk of gestational diabetes mellitus: A Chinese nested case-control study. Frontiers in Endocrinology 2023, 13 https://doi.org/10.3389/fendo.2022.1047866
    17. Liwei Cao, Lizhen Wu, Cheng Li, Yidan Tu, Hao Wu, Bin Shen, Jianxin Meng, Xin‐Qi Hao, Bing Yan, Feng‐yu Li, Fan Xia, Yu Huang. Underwater Superoleophobic‐Oleophilic Chips for Femtomolar Aflatoxins Identification. Chinese Journal of Chemistry 2022, 40 (12) , 1464-1470. https://doi.org/10.1002/cjoc.202100904
    18. Yu. M. Polyak, M. S. Polyak. The role of cyanotoxins in human and animal pathology (а review). Journal of microbiology, epidemiology and immunobiology 2022, 99 (2) , 231-243. https://doi.org/10.36233/0372-9311-230
    19. Rui Cheng, Hui Zhu, Jingfu Wang, Shengnan Hou, Brian Shutes, Baixing Yan. Removal of microcystin (MC-LR) in constructed wetlands integrated with microbial fuel cells: Efficiency, bioelectricity generation and microbial response. Journal of Environmental Management 2022, 309 , 114669. https://doi.org/10.1016/j.jenvman.2022.114669
    20. Kunyang Liu, Xiaonan Zhao, Meihong Guo, Jinling Zhu, Dongmei Li, Jie Ding, Xiaodong Han, Jiang Wu. Microcystin-leucine arginine (MC-LR) induces mouse ovarian inflammation by promoting granulosa cells to produce inflammatory cytokine via activation of cGAS-STING signaling. Toxicology Letters 2022, 358 , 6-16. https://doi.org/10.1016/j.toxlet.2022.01.003
    21. Guanghui Xu, Yang Luo, Dihui Xu, Yuhan Ma, Yabing Chen, Xiaodong Han. Male reproductive toxicity induced by Microcystin-leucine-arginine (MC-LR). Toxicon 2022, 210 , 78-88. https://doi.org/10.1016/j.toxicon.2022.02.007
    22. Ji Zhao, Hong‐Qiang Chen, Hui‐Fang Yang, Xiao‐Yu Li, Wen‐Bin Liu. Gene expression network related to DNA methylation and miRNA regulation during the process of aflatoxin B1‐induced malignant transformation of L02 cells. Journal of Applied Toxicology 2022, 42 (3) , 475-489. https://doi.org/10.1002/jat.4233
    23. Apurva Lad, Joshua D. Breidenbach, Robin C. Su, Jordan Murray, Rebecca Kuang, Alison Mascarenhas, John Najjar, Shivani Patel, Prajwal Hegde, Mirella Youssef, Jason Breuler, Andrew L. Kleinhenz, Andrew P. Ault, Judy A. Westrick, Nikolai N. Modyanov, David J. Kennedy, Steven T. Haller. As We Drink and Breathe: Adverse Health Effects of Microcystins and Other Harmful Algal Bloom Toxins in the Liver, Gut, Lungs and Beyond. Life 2022, 12 (3) , 418. https://doi.org/10.3390/life12030418
    24. Lingqiao Wang, Huidong Jin, Yi Zeng, Yao Tan, Jia Wang, Wenjuan Fu, Weiyan Chen, Ke Cui, Zhiqun Qiu, Ziyuan Zhou. HOXB4 Mis-Regulation Induced by Microcystin-LR and Correlated With Immune Infiltration Is Unfavorable to Colorectal Cancer Prognosis. Frontiers in Oncology 2022, 12 https://doi.org/10.3389/fonc.2022.803493
    25. Chun Pan, Minghao Yan, Haibo Jin, Hongqian Guo, Xiaodong Han. Chronic exposure to MC-LR increases the risks of microcytic anemia: Evidence from human and mice. Environmental Pollution 2021, 288 , 117966. https://doi.org/10.1016/j.envpol.2021.117966
    26. Mohamed F. Abdallah, Wannes H. R. Van Hassel, Mirjana Andjelkovic, Annick Wilmotte, Andreja Rajkovic. Cyanotoxins and Food Contamination in Developing Countries: Review of Their Types, Toxicity, Analysis, Occurrence and Mitigation Strategies. Toxins 2021, 13 (11) , 786. https://doi.org/10.3390/toxins13110786
    27. Ya Ma, Haohao Liu, Xingde Du, Ziang Shi, Xiaohui Liu, Rui Wang, Shiyu Zhang, Zhihui Tian, Linjia Shi, Hongxiang Guo, Huizhen Zhang. Advances in the toxicology research of microcystins based on Omics approaches. Environment International 2021, 154 , 106661. https://doi.org/10.1016/j.envint.2021.106661
    28. Tarana Arman, John Clarke. Microcystin Toxicokinetics, Molecular Toxicology, and Pathophysiology in Preclinical Rodent Models and Humans. Toxins 2021, 13 (8) , 537. https://doi.org/10.3390/toxins13080537
    29. Tarana Arman, Katherine D. Lynch, Michael Goedken, John D. Clarke. Sub-chronic microcystin-LR renal toxicity in rats fed a high fat/high cholesterol diet. Chemosphere 2021, 269 , 128773. https://doi.org/10.1016/j.chemosphere.2020.128773
    30. Hui Zeng, Yao Tan, Lingqiao Wang, Menglong Xiang, Ziyuan Zhou, Ji-an Chen, Jia Wang, Renping Zhang, Yingqiao Tian, Jiaohua Luo, Yujing Huang, Chen Lv, Weiqun Shu, Zhiqun Qiu. Association of serum microcystin levels with neurobehavior of school-age children in rural area of Southwest China: A cross-sectional study. Ecotoxicology and Environmental Safety 2021, 212 , 111990. https://doi.org/10.1016/j.ecoenv.2021.111990
    31. Fei Shen, Yanjuan Xu, Ye Wang, Jing Chen, Junzhe Shi. Rapid determination of microcystins and nodularin in surface water by on-line solid-phase extraction (SPE) with ultra-performance liquid chromatography – tandem mass spectrometry (UPLC-MS/MS). Instrumentation Science & Technology 2021, 49 (2) , 233-243. https://doi.org/10.1080/10739149.2020.1814808
    32. Chun Pan, Ling Zhang, Xiannan Meng, Haixiang Qin, Zou Xiang, Wenyue Gong, Wenxin Luo, Dongmei Li, Xiaodong Han. Chronic exposure to microcystin-LR increases the risk of prostate cancer and induces malignant transformation of human prostate epithelial cells. Chemosphere 2021, 263 , 128295. https://doi.org/10.1016/j.chemosphere.2020.128295
    33. Shiyu Zhang, Xingde Du, Haohao Liu, Michael D. Losiewic, Xinghai Chen, Ya Ma, Rui Wang, Zhihui Tian, Linjia Shi, Hongxiang Guo, Huizhen Zhang. The latest advances in the reproductive toxicity of microcystin-LR. Environmental Research 2021, 192 , 110254. https://doi.org/10.1016/j.envres.2020.110254
    34. Adam D. Biales, David C. Bencic, Robert W. Flick, Armah Delacruz, Denise A. Gordon, Weichun Huang. Global transcriptomic profiling of microcystin-LR or -RR treated hepatocytes (HepaRG). Toxicon: X 2020, 8 , 100060. https://doi.org/10.1016/j.toxcx.2020.100060
    35. Shuaishuai Xu, Xiping Yi, Wenya Liu, Chengcheng Zhang, Isaac Yaw Massey, Fei Yang, Li Tian. A Review of Nephrotoxicity of Microcystins. Toxins 2020, 12 (11) , 693. https://doi.org/10.3390/toxins12110693
    36. Meaghan A. Labine, Emma Shu, Lin Xue, Giselle Mak, Jane Griffith, Gerald Y. Minuk. A lack of association between increases in gastrointestinal, liver, and urologic cancers and cyanobacterial contamination of fresh water lakes in Manitoba. Environmental Science and Pollution Research 2020, 27 (28) , 35852-35858. https://doi.org/10.1007/s11356-020-09731-y
    37. Xilian Ouyang, Lin Tang, Chengyang Feng, Bo Peng, Yani Liu, Xiaoya Ren, Xu Zhu, Jisui Tan, Xingxin Hu. Au/CeO2/g-C3N4 heterostructures: Designing a self-powered aptasensor for ultrasensitive detection of Microcystin-LR by density functional theory. Biosensors and Bioelectronics 2020, 164 , 112328. https://doi.org/10.1016/j.bios.2020.112328
    38. Hongyan Guo, Jian Ji, Jia-sheng Wang, Xiulan Sun. Co-contamination and interaction of fungal toxins and other environmental toxins. Trends in Food Science & Technology 2020, 103 , 162-178. https://doi.org/10.1016/j.tifs.2020.06.021
    39. Lingqiao Wang, Lixiong He, Hui Zeng, Wenjuan Fu, Jia Wang, Yao Tan, Chuanfen Zheng, Zhiqun Qiu, Jiaohua Luo, Chen Lv, Yujing Huang, Weiqun Shu. Low-dose microcystin-LR antagonizes aflatoxin B1 induced hepatocarcinogenesis through decreasing cytochrome P450 1A2 expression and aflatoxin B1-DNA adduct generation. Chemosphere 2020, 248 , 126036. https://doi.org/10.1016/j.chemosphere.2020.126036
    40. Changliang Zhang, Jing Wang, Jinling Zhu, Yabing Chen, Xiaodong Han. Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons. Science of The Total Environment 2020, 703 , 134702. https://doi.org/10.1016/j.scitotenv.2019.134702
    41. Minghao Yan, Gu Shen, Yuan Zhou, Xiannan Meng, Xiaodong Han. The role of ERK-RSK signaling in the proliferation of intrahepatic biliary epithelial cells exposed to microcystin-leucine arginine. Biochemical and Biophysical Research Communications 2020, 521 (2) , 492-498. https://doi.org/10.1016/j.bbrc.2019.10.143
    42. Huiyan Zhang, Gerard Bryan Gonzales, Natalia V. Beloglazova, Sarah De Saeger, Jianzhong Shen, Suxia Zhang, Shupeng Yang, Zhanhui Wang. Development of a validated direct injection-liquid chromatographic tandem mass spectrometric method under negative electrospray ionization for quantitation of nine microcystins and nodularin-R in lake water. Journal of Chromatography A 2020, 1609 , 460432. https://doi.org/10.1016/j.chroma.2019.460432
    43. Sujuan Zhao, Shengzheng Zhong, Fang Wang, Honghui Wang, Dexiang Xu, Guangyu Li. Microcystin-LR exposure decreased the fetal weight of mice by disturbance of placental development and ROS-mediated endoplasmic reticulum stress in the placenta. Environmental Pollution 2020, 256 , 113362. https://doi.org/10.1016/j.envpol.2019.113362
    44. Nada Tokodi, Damjana Drobac Backović, Jelena Lujić, Ilija Šćekić, Snežana Simić, Nevena Đorđević, Tamara Dulić, Branko Miljanović, Nevena Kitanović, Zoran Marinović, Henna Savela, Jussi Meriluoto, Zorica Svirčev. Protected Freshwater Ecosystem with Incessant Cyanobacterial Blooming Awaiting a Resolution. Water 2020, 12 (1) , 129. https://doi.org/10.3390/w12010129
    45. Xiping Yi, Shuaishuai Xu, Feiyu Huang, Cong Wen, Shuilin Zheng, Hai Feng, Jian Guo, Jihua Chen, Xiangling Feng, Fei Yang. Effects of Chronic Exposure to Microcystin-LR on Kidney in Mice. International Journal of Environmental Research and Public Health 2019, 16 (24) , 5030. https://doi.org/10.3390/ijerph16245030
    46. Ji Zhao, Hong-qiang Chen, Hui-fang Yang, Yan Li, Dong-jiao Chen, Yu-jing Huang, Li-xiong He, Chuan-fen Zheng, Ling-qiao Wang, Jia Wang, Na Zhang, Jia Cao, Jin-yi Liu, Wei-qun Shu, Wen-bin Liu. Epigenetic silencing of ALX4 regulates microcystin-LR induced hepatocellular carcinoma through the P53 pathway. Science of The Total Environment 2019, 683 , 317-330. https://doi.org/10.1016/j.scitotenv.2019.05.144
    47. Jing Wang, Yabing Chen, Changliang Zhang, Zou Xiang, Jie Ding, Xiaodong Han. Learning and memory deficits and alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR. Journal of Hazardous Materials 2019, 373 , 504-518. https://doi.org/10.1016/j.jhazmat.2019.03.106
    48. Zhikuan Wang, Guangyu Li, Qin Wu, Chunsheng Liu, JianZhong Shen, Wei Yan. Microcystin-LR exposure induced nephrotoxicity by triggering apoptosis in female zebrafish. Chemosphere 2019, 214 , 598-605. https://doi.org/10.1016/j.chemosphere.2018.09.103
    49. Brett Greer, Julie P. Meneely, Christopher T. Elliott. Uptake and accumulation of Microcystin-LR based on exposure through drinking water: An animal model assessing the human health risk. Scientific Reports 2018, 8 (1) https://doi.org/10.1038/s41598-018-23312-7
    50. Nataliya A. Egorova, N. V. Kuz, O. O. Sinitsyna. MATERIALS FOR THE SUBSTANTIATION OF HYGIENIC STANDARD OF MICROCYSTIN-LR IN WATER OF WATER OBJECTS. Hygiene and sanitation 2018, 97 (11) , 1046-1052. https://doi.org/10.18821/0016-9900-2018-97-11-1046-52
    51. Jing Wang, Yabing Chen, Zhangpeng Chen, Zou Xiang, Jie Ding, Xiaodong Han. Microcystin-leucine arginine inhibits gonadotropin-releasing hormone synthesis in mice hypothalamus. Ecotoxicology and Environmental Safety 2018, 163 , 391-399. https://doi.org/10.1016/j.ecoenv.2018.07.094
    52. Julie P. Meneely, Jana Hajšlová, Rudolf Krska, Christopher T. Elliott. Assessing the combined toxicity of the natural toxins, aflatoxin B1, fumonisin B1 and microcystin-LR by high content analysis. Food and Chemical Toxicology 2018, 121 , 527-540. https://doi.org/10.1016/j.fct.2018.09.052
    53. Isaac Yaw Massey, Fei Yang, Zhen Ding, Shu Yang, Jian Guo, Clara Tezi, Muwaffak Al-Osman, Robert Boukem Kamegni, Weiming Zeng. Exposure routes and health effects of microcystins on animals and humans: A mini-review. Toxicon 2018, 151 , 156-162. https://doi.org/10.1016/j.toxicon.2018.07.010
    54. Sujuan Zhao, Ying Liu, Fang Wang, Dexiang Xu, Ping Xie. N-acetylcysteine protects against microcystin-LR-induced endoplasmic reticulum stress and germ cell apoptosis in zebrafish testes. Chemosphere 2018, 204 , 463-473. https://doi.org/10.1016/j.chemosphere.2018.04.020
    55. Yabing Chen, Jing Wang, Xiang Chen, Dongmei Li, Xiaodong Han. Microcystin-leucine arginine mediates apoptosis and engulfment of Leydig cell by testicular macrophages resulting in reduced serum testosterone levels. Aquatic Toxicology 2018, 199 , 116-126. https://doi.org/10.1016/j.aquatox.2018.03.018
    56. Hong-qiang Chen, Ji Zhao, Yan Li, Li-xiong He, Yu-jing Huang, Wei-qun Shu, Jia Cao, Wen-bin Liu, Jin-yi Liu. Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells. Toxicology Letters 2018, 289 , 42-53. https://doi.org/10.1016/j.toxlet.2018.03.003
    57. Yabing Chen, Jing Wang, Chun Pan, Dongmei Li, Xiaodong Han. Microcystin–leucine–arginine causes blood–testis barrier disruption and degradation of occludin mediated by matrix metalloproteinase-8. Cellular and Molecular Life Sciences 2018, 75 (6) , 1117-1132. https://doi.org/10.1007/s00018-017-2687-6
    58. Guocheng Liu, Hao Zheng, Xiaowei Zhai, Zhenyu Wang. Characteristics and mechanisms of microcystin-LR adsorption by giant reed-derived biochars: Role of minerals, pores, and functional groups. Journal of Cleaner Production 2018, 176 , 463-473. https://doi.org/10.1016/j.jclepro.2017.12.156
    59. Wenyi Liu, Lingqiao Wang, Chuanfen Zheng, Lebin Liu, Jia Wang, Daibo Li, Yao Tan, Xilong Zhao, Lixiong He, Weiqun Shu. Microcystin-LR increases genotoxicity induced by aflatoxin B1 through oxidative stress and DNA base excision repair genes in human hepatic cell lines. Environmental Pollution 2018, 233 , 455-463. https://doi.org/10.1016/j.envpol.2017.10.067
    60. Hui Zeng, Hui Lin, Wenyi Liu, Jia Wang, Lingqiao Wang, Chuanfen Zheng, Yao Tan, Yujing Huang, Lixiong He, Jiaohua Luo, Chaowen Pu, Renping Zhang, Xiaohong Yang, Yingqiao Tian, Zhiqun Qiu, Ji-an Chen, Yang Luo, Xiaobin Feng, Guosheng Xiao, Liping Wu, Weiqun Shu. Prevalence of metabolic syndrome among adults with liver function injury in rural area of Southwest China: A cross-sectional study. Scientific Reports 2017, 7 (1) https://doi.org/10.1038/s41598-017-05791-2
    61. Menghong Hu, Xiancheng Qu, Lisha Pan, Chunxue Fu, Peixuan Jia, Qigen Liu, Youji Wang. Effects of toxic Microcystis aeruginosa on the silver carp Hypophthalmichtys molitrix revealed by hepatic RNA-seq and miRNA-seq. Scientific Reports 2017, 7 (1) https://doi.org/10.1038/s41598-017-10335-9
    62. Yabing Chen, Jing Wang, Qin Zhang, Zou Xiang, Dongmei Li, Xiaodong Han. Microcystin-leucine arginine exhibits immunomodulatory roles in testicular cells resulting in orchitis. Environmental Pollution 2017, 229 , 964-975. https://doi.org/10.1016/j.envpol.2017.07.081
    63. Brett Greer, Ronald Maul, Katrina Campbell, Christopher T Elliott. Detection of freshwater cyanotoxins and measurement of masked microcystins in tilapia from Southeast Asian aquaculture farms. Analytical and Bioanalytical Chemistry 2017, 409 (16) , 4057-4069. https://doi.org/10.1007/s00216-017-0352-4
    64. Honghui Rong, Xin Cheng, Jose M. Garcia, Ling Zhang, Lu Lu, Jian Fang, Mingshan Le, Peng Hu, Xinlu Dong, Junli Yang, Ya Wang, Ting Luo, Jun Liu, Ji-an Chen, . Survey of health literacy level and related influencing factors in military college students in Chongqing, China: A cross-sectional analysis. PLOS ONE 2017, 12 (5) , e0177776. https://doi.org/10.1371/journal.pone.0177776
    65. Franca M. Buratti, Maura Manganelli, Susanna Vichi, Mara Stefanelli, Simona Scardala, Emanuela Testai, Enzo Funari. Cyanotoxins: producing organisms, occurrence, toxicity, mechanism of action and human health toxicological risk evaluation. Archives of Toxicology 2017, 91 (3) , 1049-1130. https://doi.org/10.1007/s00204-016-1913-6
    66. Yiyi Feng, Junguo Ma, Ruichen Xiang, Xiaoyu Li. Alterations in microRNA expression in the tissues of silver carp (Hypophthalmichthys molitrix) following microcystin-LR exposure. Toxicon 2017, 128 , 15-22. https://doi.org/10.1016/j.toxicon.2017.01.016
    67. Zorica Svirčev, Damjana Drobac, Nada Tokodi, Biljana Mijović, Geoffrey A. Codd, Jussi Meriluoto. Toxicology of microcystins with reference to cases of human intoxications and epidemiological investigations of exposures to cyanobacteria and cyanotoxins. Archives of Toxicology 2017, 91 (2) , 621-650. https://doi.org/10.1007/s00204-016-1921-6
    Download PDF

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    MENDELEY PAIRING EXPIRED
    Your Mendeley pairing has expired. Please reconnect