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Redox Signaling by Reactive Electrophiles and Oxidants

  • Saba Parvez
    Saba Parvez
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, Utah 84112, United States
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States
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  • , 
  • Marcus J. C. Long
    Marcus J. C. Long
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States
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  • , 
  • Jesse R. Poganik
    Jesse R. Poganik
    École Polytechnique Fédérale de Lausanne, Institute of Chemical Sciences and Engineering, 1015 Lausanne, Switzerland
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States
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  • , and 
  • Yimon Aye*
    Yimon Aye
    École Polytechnique Fédérale de Lausanne, Institute of Chemical Sciences and Engineering, 1015 Lausanne, Switzerland
    *E-mail: [email protected]
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    Orcidhttp://orcid.org/0000-0002-1256-4159
Cite this: Chem. Rev. 2018, 118, 18, 8798–8888
Publication Date (Web):August 27, 2018
https://doi.org/10.1021/acs.chemrev.7b00698
Copyright © 2018 American Chemical Society
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    Abstract

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    The concept of cell signaling in the context of nonenzyme-assisted protein modifications by reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely complex topic that has been approached from numerous different and multidisciplinary angles. Our Review reflects on five aspects critical for understanding how nature harnesses these noncanonical post-translational modifications to coordinate distinct cellular activities: (1) specific players and their generation, (2) physicochemical properties, (3) mechanisms of action, (4) methods of interrogation, and (5) functional roles in health and disease. Emphasis is primarily placed on the latest progress in the field, but several aspects of classical work likely forgotten/lost are also recollected. For researchers with interests in getting into the field, our Review is anticipated to function as a primer. For the expert, we aim to stimulate thought and discussion about fundamentals of redox signaling mechanisms and nuances of specificity/selectivity and timing in this sophisticated yet fascinating arena at the crossroads of chemistry and biology.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.chemrev.7b00698.

    • A selection of HNE-sensitive proteins reported in the literature, energy diagram, oxidation of GSH by HOCl reaction, structures of other various compounds discussed, and cysteine adducts to isothiocyanates reactions (PDF)

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