ACS Publications. Most Trusted. Most Cited. Most Read
My Activity
CONTENT TYPES

Figure 1Loading Img

Separation, Characterization, and Quantitation of Phenolic Acids in a Little-Known Blueberry (Vaccinium arctostaphylos L.) Fruit by HPLC-MS

View Author Information
Department of Biology, Karadeniz Technical University, 61080 Trabzon, Turkey, and Laboratory of Growth Regulators, Palacký University and Institute of Experimental Botany ASCR, Slechtitelu 11, CZ-783 71 Olomouc, Czech Republic
Cite this: J. Agric. Food Chem. 2005, 53, 21, 8116–8122
Publication Date (Web):September 16, 2005
https://doi.org/10.1021/jf058057y
Copyright © 2005 American Chemical Society

    Article Views

    2685

    Altmetric

    -

    Citations

    107
    LEARN ABOUT THESE METRICS
    Other access options

    Abstract

    The aim of this study was the qualitative and quantitative determination of free, ester, glycoside, and ester-bound phenolic acids in the blueberry (Vaccinium arctostaphylos L.) fruit. A method for the determination of the profile of phenolic acids of four different phenolic fractions in the fruit was developed using high-performance liquid chromatography−mass spectrometry (HPLC-MS). Thirteen compounds (gallic, protocatechuic, p-hydroxybenzoic, m-hydroxybenzoic, gentisic, chlorogenic, p-coumaric, caffeic, ferulic, syringic, sinapic, salicylic, and trans-cinnamic acids) were identified and quantified in the berry. These experimental results showed that the predominant phenolic acid in the fruit of V. arctostaphylos is caffeic acid in free and insoluble ester-bound forms and p-coumaric acid in soluble ester and glycoside forms. Seven phenolic acids were identified as hydroxybenzoic acid derivatives (HBAs) and four as hydroxycinnamic acid derivatives (HCAs). Total content of HBAs and HCAs in the four phenolic fractions constituted 30.1 and 69.9% of the free, 27.9 and 72.1% of the ester, 24.7 and 75.3% of the glycoside, and 51.7 and 48.3% of the ester-bound forms, respectively. Total phenolics as the sum of individual phenolic acids identified is 698.5 ng/g of fresh weight (fw) for the free, 3399.2 ng/g of fw for the ester, 3522.1 ng/g of fw for the glycoside, and 3671.6 ng/g of fw for the ester-bound phenolic fractions. The present results were compared with reported levels of phenolic acids in the fruits of different Vaccinium species. These data suggest that the fruit can be considered as a potentially good dietary source of phenolic acids.

    Keywords: Blueberry; fruit; Vaccinium arctostaphylos; phenolic acids; HPLC-MS

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. You can change your affiliated institution below.

    *

     Author to whom correspondence should be addressed (telephone 90 0 462 377 3712; fax 90 0 462 325 31 95; e-mail [email protected]).

     Karadeniz Technical University.

    §

     Palacký University and Institute of Experimental Botany ASCR.

    Cited By

    This article is cited by 107 publications.

    1. Sarah Lee, Eun Sung Jung, Seon-Gil Do, Ga-young Jung, Gwanpil Song, Jung-min Song, and Choong Hwan Lee . Correlation between Species-Specific Metabolite Profiles and Bioactivities of Blueberries (Vaccinium spp.). Journal of Agricultural and Food Chemistry 2014, 62 (9) , 2126-2133. https://doi.org/10.1021/jf405272b
    2. Jozef Kováčik, Bořivoj Klejdus, Josef Hedbavny, František Štork, and Jiřı́ Grúz . Modulation of Copper Uptake and Toxicity by Abiotic Stresses in Matricaria chamomilla Plants. Journal of Agricultural and Food Chemistry 2012, 60 (27) , 6755-6763. https://doi.org/10.1021/jf3013426
    3. Yixiang Liu, Dan Wang, Di Zhang, Yechun Lv, Ying Wei, Wei Wu, Feng Zhou, Miaomiao Tang, Ting Mao, Mengmeng Li, and Baoping Ji . Inhibitory Effect of Blueberry Polyphenolic Compounds on Oleic Acid-Induced Hepatic Steatosis in Vitro. Journal of Agricultural and Food Chemistry 2011, 59 (22) , 12254-12263. https://doi.org/10.1021/jf203136j
    4. Jozef Kováčik, Bořivoj Klejdus, František Štork, and Josef Hedbavny . Nitrate Deficiency Reduces Cadmium and Nickel Accumulation in Chamomile Plants. Journal of Agricultural and Food Chemistry 2011, 59 (9) , 5139-5149. https://doi.org/10.1021/jf104793b
    5. Guihua Xu,, Xingqian Ye,, Jianchu Chen, and, Donghong Liu. Effect of Heat Treatment on the Phenolic Compounds and Antioxidant Capacity of Citrus Peel Extract. Journal of Agricultural and Food Chemistry 2007, 55 (2) , 330-335. https://doi.org/10.1021/jf062517l
    6. Melike Yildirim Akatin, Faik Ahmet Ayaz, Gulsum Merve Boyraci, Mehtap Er Kemal, Nevzat Batan, Nesrin Colak. An evaluation of the antioxidant potential and in vitro enzyme inhibition profile of selected bryophytes from Northeast Anatolia (Türkiye). Journal of Biomolecular Structure and Dynamics 2024, 6 , 1-13. https://doi.org/10.1080/07391102.2024.2313155
    7. Aynur Kurt-Celebi, Nesrin Colak, Sanja Ćavar Zeljković, Petr Tarkowski, Ahmet Yasar Zengin, Faik Ahmet Ayaz. Pre- and post-melatonin mitigates the effect of ionizing radiation-induced damage in wheat by modulating the antioxidant machinery. Plant Physiology and Biochemistry 2023, 204 , 108045. https://doi.org/10.1016/j.plaphy.2023.108045
    8. Miao Wang, Yihan Li, Canying Li, Hengping Xu, Tong Sun, Yonghong Ge. Melatonin induces resistance against Penicillium expansum in apple fruit through enhancing phenylpropanoid metabolism. Physiological and Molecular Plant Pathology 2023, 127 , 102082. https://doi.org/10.1016/j.pmpp.2023.102082
    9. Mi Guo, Canying Li, Rui Huang, Linhong Qu, Jiaxin Liu, Chenyang Zhang, Yonghong Ge. Ferulic acid enhanced resistance against blue mold of Malus domestica by regulating reactive oxygen species and phenylpropanoid metabolism. Postharvest Biology and Technology 2023, 202 , 112378. https://doi.org/10.1016/j.postharvbio.2023.112378
    10. Hasan Fallah Huseini, Khalil Mohamadzadeh, Saeed Kianbakht, Sayed Mohammad Mohammadi, Maryam Ahvazi, Mahboobeh Sadat Hooseini, Nahid Khalili, Behzad Foroutan, Mehdi Saberi, Amir Baghaei, Reza Mohtashami. Antihyperglycemic efficacy and safety of AKROPOL, a Persian medicine poly-herbal extract mixture, in the treatment of type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial. The Payam-e-Marefat-Kabul Education University 2023, 22 (86) , 1-13. https://doi.org/10.61186/jmp.22.86.1
    11. Manimegalai Sengani, Shreya Chakraborty, Menaka Priya Balaji, Rajakumar Govindasamy, Tahani Awad Alahmadi, Sami Al Obaid, Indira Karuppusamy, Nguyen Thuy Lan Chi, Kathirvel Brindhadevi, Devi Rajeswari V. Anti-diabetic efficacy and selective inhibition of methyl glyoxal, intervention with biogenic Zinc oxide nanoparticle. Environmental Research 2023, 216 , 114475. https://doi.org/10.1016/j.envres.2022.114475
    12. Arnold A. Shamilov, Daniil N. Olennikov, Dmitryi I. Pozdnyakov, Valentina N. Bubenchikova, Ekaterina R. Garsiya, Mikhail V. Larskii. Caucasian Blueberry: Comparative Study of Phenolic Compounds and Neuroprotective and Antioxidant Potential of Vaccinium myrtillus and Vaccinium arctostaphylos Leaves. Life 2022, 12 (12) , 2079. https://doi.org/10.3390/life12122079
    13. Fábio Jesus, Ana C. Gonçalves, Gilberto Alves, Luís R. Silva. Health Benefits of Prunus avium Plant Parts: An Unexplored Source Rich in Phenolic Compounds. Food Reviews International 2022, 38 (sup1) , 118-146. https://doi.org/10.1080/87559129.2020.1854781
    14. Anela Topčagić, Sanja Ćavar Zeljković, Munevera Kezić, Emin Sofić. Fatty acids and phenolic compounds composition of anise seed. Journal of Food Processing and Preservation 2022, 46 (10) https://doi.org/10.1111/jfpp.15872
    15. Jinxiang Li, Jun Liu, Qianfeng Weng. A Hydrophilic Strong Anion-Exchange Hybrid Monolith for Capillary Liquid Chromatography. LCGC Europe 2022, , 319-324. https://doi.org/10.56530/lcgc.eu.od3570x2
    16. Mustafa Cüce, Nesrin Colak, Sanja Ćavar Zeljković, Petr Tarkowski, Miroslav Strnad, Jiri Gruz, Kemal Vehbi İmamoğlu, Faik Ahmet Ayaz. An evaluation of volatiles and phenolic compounds in conjunction with the antioxidant capacity of endemic endangered species of Erodium hendrikii Alpinar. South African Journal of Botany 2022, 149 , 458-467. https://doi.org/10.1016/j.sajb.2022.06.010
    17. Ye Han, Ruirui Yang, Qihui Wang, Bin Wang, Dov Prusky. Sodium silicate promotes wound healing by inducing the deposition of suberin polyphenolic and lignin in potato tubers. Frontiers in Plant Science 2022, 13 https://doi.org/10.3389/fpls.2022.942022
    18. Zhicheng Li, Xiaoqin Xu, Sulin Xue, Di Gong, Bin Wang, Xiaoyuan Zheng, Pengdong Xie, Yang Bi, Dov Prusky. Preharvest multiple sprays with chitosan promotes the synthesis and deposition of lignin at wounds of harvested muskmelons. International Journal of Biological Macromolecules 2022, 206 , 167-174. https://doi.org/10.1016/j.ijbiomac.2022.02.130
    19. Yatong Zhu, Yuanyuan Zong, Wei Liang, Rui Kong, Di Gong, Ye Han, Yongcai Li, Yang Bi, Dov Prusky. Sorbitol immersion accelerates the deposition of suberin polyphenolic and lignin at wounds of potato tubers by activating phenylpropanoid metabolism. Scientia Horticulturae 2022, 297 , 110971. https://doi.org/10.1016/j.scienta.2022.110971
    20. Ye Han, Ruirui Yang, Xuejiao Zhang, Qihui Wang, Bin Wang, Xiaoyuan Zheng, Yongcai Li, Dov Prusky, Yang Bi. Brassinosteroid Accelerates Wound Healing of Potato Tubers by Activation of Reactive Oxygen Metabolism and Phenylpropanoid Metabolism. Foods 2022, 11 (7) , 906. https://doi.org/10.3390/foods11070906
    21. Nesrin Colak, Aynur Kurt-Celebi, Jiri Gruz, Miroslav Strnad, Sema Hayirlioglu-Ayaz, Myoung-Gun Choung, Tuba Esatbeyoglu, Faik Ahmet Ayaz. The Phenolics and Antioxidant Properties of Black and Purple versus White Eggplant Cultivars. Molecules 2022, 27 (8) , 2410. https://doi.org/10.3390/molecules27082410
    22. Lirong Yu, Yuanyuan Zong, Ye Han, Xuemei Zhang, Yatong Zhu, William Oyom, Di Gong, Dov Prusky, Yang Bi. Both chitosan and chitooligosaccharide treatments accelerate wound healing of pear fruit by activating phenylpropanoid metabolism. International Journal of Biological Macromolecules 2022, 205 , 483-490. https://doi.org/10.1016/j.ijbiomac.2022.02.098
    23. Sergio Izcara, Sonia Morante-Zarcero, Natalia Casado, Isabel Sierra. Study of the Phenolic Compound Profile of Arbutus unedo L. Fruits at Different Ripening Stages by HPLC-TQ-MS/MS. Applied Sciences 2021, 11 (24) , 11616. https://doi.org/10.3390/app112411616
    24. Yatong Zhu, Yuanyuan Zong, Wei Liang, Ackah Sabina, Xiuwei Chai, Yongcai Li, Yang Bi, Prusky Dov. β-Aminobutyric acid treatment accelerates the deposition of suberin polyphenolic and lignin at wound sites of potato tubers during healing. Postharvest Biology and Technology 2021, 179 , 111566. https://doi.org/10.1016/j.postharvbio.2021.111566
    25. Rosa Tundis, Maria C. Tenuta, Monica R. Loizzo, Marco Bonesi, Federica Finetti, Lorenza Trabalzini, Brigitte Deguin. Vaccinium Species (Ericaceae): From Chemical Composition to Bio-Functional Activities. Applied Sciences 2021, 11 (12) , 5655. https://doi.org/10.3390/app11125655
    26. Xiaoyuan Zheng, Hong Jiang, Esrat Mahmud Silvy, Shijia Zhao, Xiuwei Chai, Bin Wang, Zhicheng Li, Yang Bi, Dov Prusky. Candida Oleophila Proliferated and Accelerated Accumulation of Suberin Poly Phenolic and Lignin at Wound Sites of Potato Tubers. Foods 2021, 10 (6) , 1286. https://doi.org/10.3390/foods10061286
    27. Hui Li, Xiaoxuan Yu, Chenxi Li, Lei Ma, Zhenyu Zhao, Shuwen Guan, Liping Wang. Caffeic acid protects against Aβ toxicity and prolongs lifespan in Caenorhabditis elegans models. Food & Function 2021, 12 (3) , 1219-1231. https://doi.org/10.1039/D0FO02784G
    28. Yannan Jin, Randolph R. J. Arroo. Application of dietary supplements in the prevention of type 2 diabetes-related cardiovascular complications. Phytochemistry Reviews 2021, 20 (1) , 181-209. https://doi.org/10.1007/s11101-020-09710-8
    29. Sabrine Ben Lataief, Mohamed-Nizar Zourgui, Rami Rahmani, Hanen Najjaa, Néji Gharsallah, Lazhar Zourgui. Chemical composition, antioxidant, antimicrobial and cytotoxic activities of bioactive compounds extracted from Opuntia dillenii cladodes. Journal of Food Measurement and Characterization 2021, 15 (1) , 782-794. https://doi.org/10.1007/s11694-020-00671-2
    30. Alam Zeb. Phenolic Antioxidants in Fruits. 2021, 89-129. https://doi.org/10.1007/978-3-030-74768-8_3
    31. Sunny Dhiman, Gunjan Mukherjee. Gallic Acid (GA): A Multifaceted Biomolecule Transmuting the Biotechnology Era. 2021, 163-202. https://doi.org/10.1007/978-981-15-4439-2_8
    32. Xiangzhen Ge, Yan Zhu, Zhicheng Li, Yang Bi, Jing Yang, Junlian Zhang, Dov Prusky. Preharvest multiple fungicide stroby sprays promote wound healing of harvested potato tubers by activating phenylpropanoid metabolism. Postharvest Biology and Technology 2021, 171 , 111328. https://doi.org/10.1016/j.postharvbio.2020.111328
    33. Mohamed Nizar Zourgui, Mbarka Hfaiedh, Dalel Brahmi, Wissal Affi, Néji Gharsallah, Lazhar Zourgui, Mohamed Amri. Phytochemical screening, antioxidant and antimicrobial activities of Opuntia streptacantha fruit skin. Journal of Food Measurement and Characterization 2020, 14 (5) , 2721-2733. https://doi.org/10.1007/s11694-020-00518-w
    34. Danijel D. Milinčić, Uroš D. Vojinović, Aleksandar Ž. Kostić, Mirjana B. Pešić, Bojana D. Špirović Trifunović, Dragica V. Brkić, Milan Ž. Stević, Milan O. Kojić, Nemanja S. Stanisavljević. In vitro assessment of pesticide residues bioaccessibility in conventionally grown blueberries as affected by complex food matrix. Chemosphere 2020, 252 , 126568. https://doi.org/10.1016/j.chemosphere.2020.126568
    35. Francesca Truzzi, Maria Chiara Valerii, Camilla Tibaldi, Yanxin Zhang, Veronika Abduazizova, Enzo Spisni, Giovanni Dinelli. Are Supplements Safe? Effects of Gallic and Ferulic Acids on In Vitro Cell Models. Nutrients 2020, 12 (6) , 1591. https://doi.org/10.3390/nu12061591
    36. Senem Şanlı, Onur Güneşer, Sinem Kılıçarslan, Nurullah Şanlı. Screening of eighteen polyphenolic compounds in different carob pekmez by green capillary electrophoresis method. SN Applied Sciences 2020, 2 (4) https://doi.org/10.1007/s42452-020-2387-y
    37. Mohsen Akbari Bazm, Nader Goodarzi, Seyed Reza Shahrokhi, Mozafar Khazaei. The effects of hydroalcoholic extract of Vaccinium arctostaphylos L. on sperm parameters, oxidative injury and apoptotic changes in oxymetholone‐induced testicular toxicity in mouse. Andrologia 2020, 52 (3) https://doi.org/10.1111/and.13522
    38. Filiz YÜKSEK. The Effects of Ecological Factors on Some Properties of Fruits in Vaccinium arctostaphylos (L.) Populations in The Fırtına Valley. Journal of Anatolian Environmental and Animal Sciences 2020, 5 (1) , 19-24. https://doi.org/10.35229/jaes.638742
    39. Moonkyeung Choi, Yu-Ra Kang, Hyo Don Zu, In-Sook Lim, Sung Keun Jung, Yoon Hyuk Chang. Effects of Time on Phenolics and in vitro Bioactivity in Autoclave Extraction of Graviola (Annona muricata) Leaf. Biotechnology and Bioprocess Engineering 2020, 25 (1) , 9-15. https://doi.org/10.1007/s12257-019-0259-3
    40. Mahdi Jamshidi, Sara Torabi, Mansoureh Tavan, Ali Azizi, Sadegh Khazalpour. Electrochemical Behavior and LC-MS Analysis of Anthocyanin’s in Vaccinium Arctostaphylos L. Extract: The Molecular Modelling of Potential Inhibition to COVID-19 and ROS Generation Receptors. Journal of The Electrochemical Society 2020, 167 (15) , 155505. https://doi.org/10.1149/1945-7111/abaa6a
    41. Milica Fotirić Akšić, Dragana Dabić Zagorac, Milica Sredojević, Jasminka Milivojević, Uroš Gašić, Mekjell Meland, Maja Natić. Chemometric Characterization of Strawberries and Blueberries according to Their Phenolic Profile: Combined Effect of Cultivar and Cultivation System. Molecules 2019, 24 (23) , 4310. https://doi.org/10.3390/molecules24234310
    42. Hong Jiang, Bin Wang, Li Ma, Xiaoyuan Zheng, Di Gong, Huali Xue, Yang Bi, Yi Wang, Zhong Zhang, Dov Prusky. Benzo-(1, 2, 3)-thiadiazole-7-carbothioic acid s-methyl ester (BTH) promotes tuber wound healing of potato by elevation of phenylpropanoid metabolism. Postharvest Biology and Technology 2019, 153 , 125-132. https://doi.org/10.1016/j.postharvbio.2019.03.003
    43. Solomon Habtemariam. Bilberries and blueberries as potential modulators of type 2 diabetes and associated diseases. 2019, 135-175. https://doi.org/10.1016/B978-0-08-102922-0.00007-9
    44. Mustafa Cüce, Tuba Bekircan, Atalay Sökmen. Phenolic Constituents of Vaccinium Species from Both Natural Resources and Micropropagated Plantlets. International Journal of Secondary Metabolite 2018, 5 (4) , 304-311. https://doi.org/10.21448/ijsm.445551
    45. Ying Xue, Xian-Shun Xu, Li Yong, Bin Hu, Xing-De Li, Shi-Hong Zhong, Yi Li, Jing Xie, Lin-Sen Qing. Optimization of Vortex-Assisted Dispersive Liquid-Liquid Microextraction for the Simultaneous Quantitation of Eleven Non-Anthocyanin Polyphenols in Commercial Blueberry Using the Multi-Objective Response Surface Methodology and Desirability Function Approach. Molecules 2018, 23 (11) , 2921. https://doi.org/10.3390/molecules23112921
    46. Ruixin Gu, Minqin Zhang, Hu Meng, Dandan Xu, Yonghua Xie. Gallic acid targets acute myeloid leukemia via Akt/mTOR-dependent mitochondrial respiration inhibition. Biomedicine & Pharmacotherapy 2018, 105 , 491-497. https://doi.org/10.1016/j.biopha.2018.05.158
    47. Abolfazl Bayrami, Shadi Parvinroo, Aziz Habibi-Yangjeh, Shima Rahim Pouran. Bio-extract-mediated ZnO nanoparticles: microwave-assisted synthesis, characterization and antidiabetic activity evaluation. Artificial Cells, Nanomedicine, and Biotechnology 2018, 46 (4) , 730-739. https://doi.org/10.1080/21691401.2017.1337025
    48. Takuya Yamane. Beneficial Effects of Anthocyanin From Natural Products on Lifestyle-Related Diseases Through Inhibition of Protease Activities. 2018, 245-264. https://doi.org/10.1016/B978-0-444-64056-7.00008-8
    49. Yang Huang, Guangyun Tang, Tingting Zhang, Marianne Fillet, Jacques Crommen, Zhengjin Jiang. Supercritical fluid chromatography in traditional Chinese medicine analysis. Journal of Pharmaceutical and Biomedical Analysis 2018, 147 , 65-80. https://doi.org/10.1016/j.jpba.2017.08.021
    50. Dinesh C Bilehal, Mahadev B. Chetti, Deepa G. T, Mahadev C. Khethagoudar. Analysis of Pesticide Residues in Chili (Capsicum annuum L.) using Ultra Performance Liquid Chromatography with UV Detection. 2017https://doi.org/10.5772/intechopen.70061
    51. Nesrin Colak, Anja K. Primetta, Kaisu R. Riihinen, Laura Jaakola, Jiři Grúz, Miroslav Strnad, Hülya Torun, Faik Ahmet Ayaz. Phenolic compounds and antioxidant capacity in different-colored and non-pigmented berries of bilberry ( Vaccinium myrtillus L.). Food Bioscience 2017, 20 , 67-78. https://doi.org/10.1016/j.fbio.2017.06.004
    52. Guihua Xu, Donghong Liu, Yaqin Ma, Tian Ding. Phenolic Compounds and Bioactive Agents in Citrus Fruits. 2017, 169-210. https://doi.org/10.1201/9781315369068-6
    53. Erna Karalija, Edina Muratović, Petr Tarkowski, Sanja Ćavar Zeljković. Variation in Phenolic Composition of Knautia arvensis in Correlation with Geographic Area and Plant Organ. Natural Product Communications 2017, 12 (4) , 1934578X1701200. https://doi.org/10.1177/1934578X1701200421
    54. Gádor-Indra Hidalgo, María Almajano. Red Fruits: Extraction of Antioxidants, Phenolic Content, and Radical Scavenging Determination: A Review. Antioxidants 2017, 6 (1) , 7. https://doi.org/10.3390/antiox6010007
    55. Ok-Ju Kang. Distribution of free, esterified, and insoluble bound forms of phenolics in tea seeds and their antioxidant activity. Food Science and Biotechnology 2017, 26 (1) , 121-127. https://doi.org/10.1007/s10068-017-0016-3
    56. Nesrin Colak, Hülya Torun, Jiri Gruz, Miroslav Strnad, Isidro Hermosín-Gutiérrez, Sema Hayirlioglu-Ayaz, Faik Ahmet Ayaz. Bog bilberry phenolics, antioxidant capacity and nutrient profile. Food Chemistry 2016, 201 , 339-349. https://doi.org/10.1016/j.foodchem.2016.01.062
    57. Nesrin Colak, Ahmet Yaşar Zengin, Faik Ahmet Ayaz. The effect of anthocyanin-rich bilberry extract on the antioxidant system in roots of barley (Hordeum vulgare L.) cultivars under ionizing radiation. Acta Physiologiae Plantarum 2015, 37 (9) https://doi.org/10.1007/s11738-015-1925-5
    58. Vivian Caetano Bochi, Helena Teixeira Godoy, M. Monica Giusti. Anthocyanin and other phenolic compounds in Ceylon gooseberry (Dovyalis hebecarpa) fruits. Food Chemistry 2015, 176 , 234-243. https://doi.org/10.1016/j.foodchem.2014.12.041
    59. Haining Yu, Shengrong Shen. Phenolic composition, antioxidant, antimicrobial and antiproliferative activities of water caltrop pericarps extract. LWT - Food Science and Technology 2015, 61 (1) , 238-243. https://doi.org/10.1016/j.lwt.2014.11.003
    60. Anna Laura Capriotti, Chiara Cavaliere, Patrizia Foglia, Susy Piovesana, Salvatore Ventura. Chromatographic Methods Coupled to Mass Spectrometry Detection for the Determination of Phenolic Acids in Plants and Fruits. Journal of Liquid Chromatography & Related Technologies 2015, 38 (3) , 353-370. https://doi.org/10.1080/10826076.2014.941263
    61. Parag Jain, Ravindra Pandey, Shiv Shankar Shukla. Natural Sources of Anti-inflammation. 2015, 25-133. https://doi.org/10.1007/978-81-322-2163-0_4
    62. A. P. Subramanian, A. A. John, M. V. Vellayappan, A. Balaji, S. K. Jaganathan, Eko Supriyanto, Mustafa Yusof. Gallic acid: prospects and molecular mechanisms of its anticancer activity. RSC Advances 2015, 5 (45) , 35608-35621. https://doi.org/10.1039/C5RA02727F
    63. Bernhard HJ Juurlink, Haya J Azouz, Alaa MZ Aldalati, Basmah MH AlTinawi, Paul Ganguly. Hydroxybenzoic acid isomers and the cardiovascular system. Nutrition Journal 2014, 13 (1) https://doi.org/10.1186/1475-2891-13-63
    64. Oliviert Martínez-Cruz, Octavio Paredes-López. Phytochemical profile and nutraceutical potential of chia seeds (Salvia hispanica L.) by ultra high performance liquid chromatography. Journal of Chromatography A 2014, 1346 , 43-48. https://doi.org/10.1016/j.chroma.2014.04.007
    65. Young-Hee Jo, Sugyeong Kim, Da-Ae Kwon, Hong Jin Lee, Hyung-Kyoon Choi, Joong-Hyuck Auh. Metabolomic Analysis of Ethyl Acetate and Methanol Extracts of Blueberry. Journal of the Korean Society of Food Science and Nutrition 2014, 43 (3) , 419-424. https://doi.org/10.3746/jkfn.2014.43.3.419
    66. Yaoyao Liu, Yonghong Ge, Yang Bi, Canying Li, Huiwen Deng, Lingang Hu, Boyu Dong. Effect of postharvest acibenzolar-S-methyl dipping on phenylpropanoid pathway metabolism in muskmelon (Cucumis melo L.) fruits. Scientia Horticulturae 2014, 168 , 113-119. https://doi.org/10.1016/j.scienta.2014.01.030
    67. Neda Nićiforović, Helena Abramovič. Sinapic Acid and Its Derivatives: Natural Sources and Bioactivity. Comprehensive Reviews in Food Science and Food Safety 2014, 13 (1) , 34-51. https://doi.org/10.1111/1541-4337.12041
    68. Geetanjali Yadav, Anshu Singh, Patrali Bhattacharya, Jude Yuvraj, Rintu Banerjee. Comparative analysis of solid-state bioprocessing and enzymatic treatment of finger millet for mobilization of bound phenolics. Bioprocess and Biosystems Engineering 2013, 36 (11) , 1563-1569. https://doi.org/10.1007/s00449-013-0924-4
    69. Mohaddese Mahboubi, Nastaran Kazempour, Mohsen Taghizadeh. In vitro Antimicrobial and Antioxidant Activity of Vaccinium arctostaphylos L. Extracts. Journal of Biologically Active Products from Nature 2013, 3 (4) , 241-247. https://doi.org/10.1080/22311866.2013.782696
    70. Efthimia I. Alevizou, Epaminondas C. Voutsas. Solubilities of p-coumaric and caffeic acid in ionic liquids and organic solvents. The Journal of Chemical Thermodynamics 2013, 62 , 69-78. https://doi.org/10.1016/j.jct.2013.02.013
    71. Mark S. Lowenthal, Melissa M. Phillips, Catherine A. Rimmer, Paul A. Rudnick, Yamil Simón-Manso, Stephen E. Stein, Dmitrii Tchekhovskoi, Karen W. Phinney. Developing qualitative LC-MS methods for characterization of Vaccinium berry Standard Reference Materials. Analytical and Bioanalytical Chemistry 2013, 405 (13) , 4451-4465. https://doi.org/10.1007/s00216-012-6346-3
    72. Hong-Xia Zhao, Shan-Cang Zhao, Li-Gang Deng, Jiang-Sheng Mao, Chang-Ying Guo, Guo-Sheng Yang, Xiao Lu, Hassan Y. Aboul-Enein. Rapid Determination of Organonitrogen, Organophosphorus and Carbamate Pesticides in Tea by Ultrahigh-Performance Liquid Chromatography–Tandem Mass Spectrometry (UPLC-MS/MS). Food Analytical Methods 2013, 6 (2) , 497-505. https://doi.org/10.1007/s12161-012-9465-8
    73. Bořivoj Klejdus, Jozef Kováčik, Petr Babula. PAL inhibitor evokes different responses in two Hypericum species. Plant Physiology and Biochemistry 2013, 63 , 82-88. https://doi.org/10.1016/j.plaphy.2012.11.019
    74. Saeed Kianbakht, Behrooz Abasi, Fataneh Hashem Dabaghian. Anti-Hyperglycemic Effect of Vaccinium arctostaphylos in Type 2 Diabetic Patients: A Randomized Controlled Trial. Complementary Medicine Research 2013, 20 (1) , 17-22. https://doi.org/10.1159/000346607
    75. Hülya Torun, Faik Ahmet Ayaz, Nesrin Colak, Jiří Grúz, Miroslav Strnad. Phenolic Acid Content and Free Radical-Scavenging Activity of Two Differently Processed Carob Tree (Ceratonia siliqua L.) Pod. Food and Nutrition Sciences 2013, 04 (05) , 547-553. https://doi.org/10.4236/fns.2013.45070
    76. Jozef Kováčik, František Štork, Bořivoj Klejdus, Jiři Grúz, Josef Hedbavny. Effect of metabolic regulators on aluminium uptake and toxicity in Matricaria chamomilla plants. Plant Physiology and Biochemistry 2012, 54 , 140-148. https://doi.org/10.1016/j.plaphy.2012.02.018
    77. Zhimin Xu. Analysis Methods of Phenolic Acids. 2012, 69-104. https://doi.org/10.1002/9781118229378.ch3
    78. Klára Kosová, Ilja Tom Prášil, Pavel Vítámvás, Petre Dobrev, Václav Motyka, Kristýna Floková, Ondřej Novák, Veronika Turečková, Jakub Rolčik, Bedřich Pešek, Alena Trávničková, Alena Gaudinová, Gabor Galiba, Tibor Janda, Eva Vlasáková, Pavla Prášilová, Radomíra Vanková. Complex phytohormone responses during the cold acclimation of two wheat cultivars differing in cold tolerance, winter Samanta and spring Sandra. Journal of Plant Physiology 2012, 169 (6) , 567-576. https://doi.org/10.1016/j.jplph.2011.12.013
    79. Jozef Kováčik, Jiři Grúz, Bořivoj Klejdus, František Štork, Josef Hedbavny. Accumulation of metals and selected nutritional parameters in the field-grown chamomile anthodia. Food Chemistry 2012, 131 (1) , 55-62. https://doi.org/10.1016/j.foodchem.2011.08.028
    80. Jozef Kováčik, Bořivoj Klejdus, Klára Repčáková. Phenolic metabolites in carnivorous plants: Inter-specific comparison and physiological studies. Plant Physiology and Biochemistry 2012, 52 , 21-27. https://doi.org/10.1016/j.plaphy.2011.11.007
    81. Elhadi M. Yahia, Fabiola Gutiérrez-Orozco, Claudia Arvizu-de Leon. Phytochemical and antioxidant characterization of mamey (Pouteria sapota Jacq. H.E. Moore & Stearn) fruit. Food Research International 2011, 44 (7) , 2175-2181. https://doi.org/10.1016/j.foodres.2010.11.029
    82. Jozef Kováčik, Bořivoj Klejdus, František Štork, Silvia Malčovská. Sensitivity of Xanthoria parietina to UV-A: Role of metabolic modulators. Journal of Photochemistry and Photobiology B: Biology 2011, 103 (3) , 243-250. https://doi.org/10.1016/j.jphotobiol.2011.04.002
    83. Xing-Qian Ye, Jian-Chu Chen, Dong-Hong Liu, Ping Jiang, John Shi, Sophia Xue, Dan Wu, Jian-Guo Xu, Yukio Kakuda. Identification of bioactive composition and antioxidant activity in young mandarin fruits. Food Chemistry 2011, 124 (4) , 1561-1566. https://doi.org/10.1016/j.foodchem.2010.08.013
    84. Jiri Gruz, Faik Ahmet Ayaz, Hülya Torun, Miroslav Strnad. Phenolic acid content and radical scavenging activity of extracts from medlar (Mespilus germanica L.) fruit at different stages of ripening. Food Chemistry 2011, 124 (1) , 271-277. https://doi.org/10.1016/j.foodchem.2010.06.030
    85. Jasenka Piljac-Žegarac, Dunja Šamec. Antioxidant stability of small fruits in postharvest storage at room and refrigerator temperatures. Food Research International 2011, 44 (1) , 345-350. https://doi.org/10.1016/j.foodres.2010.09.039
    86. Aboozar Monavar Feshani, Shideh Monatasser Kouhsari, Saeed Mohammadi. Vaccinium arctostaphylos, a common herbal medicine in Iran: Molecular and biochemical study of its antidiabetic effects on alloxan-diabetic Wistar rats. Journal of Ethnopharmacology 2011, 133 (1) , 67-74. https://doi.org/10.1016/j.jep.2010.09.002
    87. Pavel Kosina, Jana Gregorova, Jiri Gruz, Jan Vacek, Milan Kolar, Mathias Vogel, Werner Roos, Kathrin Naumann, Vilim Simanek, Jitka Ulrichova. Phytochemical and antimicrobial characterization of Macleaya cordata herb. Fitoterapia 2010, 81 (8) , 1006-1012. https://doi.org/10.1016/j.fitote.2010.06.020
    88. Yun-Ping Neo, Azis Ariffin, Chin-Ping Tan, Yew-Ai Tan. Phenolic acid analysis and antioxidant activity assessment of oil palm (E. guineensis) fruit extracts. Food Chemistry 2010, 122 (1) , 353-359. https://doi.org/10.1016/j.foodchem.2010.02.046
    89. Jozef Kováčik, Bořivoj Klejdus, Jiří Grúz, Silvia Malčovská, Josef Hedbavny. Role of ploidy in cadmium and nickel uptake by Matricaria chamomilla plants. Food and Chemical Toxicology 2010, 48 (8-9) , 2109-2114. https://doi.org/10.1016/j.fct.2010.05.012
    90. B. Stephen Inbaraj, H. Lu, T.H. Kao, B.H. Chen. Simultaneous determination of phenolic acids and flavonoids in Lycium barbarum Linnaeus by HPLC–DAD–ESI-MS. Journal of Pharmaceutical and Biomedical Analysis 2010, 51 (3) , 549-556. https://doi.org/10.1016/j.jpba.2009.09.006
    91. Yaqin Wang, Zhimou Guo, Yu Jin, Xiuli Zhang, Li Wang, Xingya Xue, Xinmiao Liang. Identification of prenyl flavonoid glycosides and phenolic acids in Epimedium koreanum Nakai by Q-TOF-MS combined with selective enrichment on “click oligo (ethylene glycol)” column. Journal of Pharmaceutical and Biomedical Analysis 2010, 51 (3) , 606-616. https://doi.org/10.1016/j.jpba.2009.09.033
    92. M.J. Simirgiotis, G. Schmeda-Hirschmann. Direct identification of phenolic constituents in Boldo Folium (Peumus boldus Mol.) infusions by high-performance liquid chromatography with diode array detection and electrospray ionization tandem mass spectrometry. Journal of Chromatography A 2010, 1217 (4) , 443-449. https://doi.org/10.1016/j.chroma.2009.11.014
    93. Tatiana S. Fukuji, Fernando G. Tonin, Marina F.M. Tavares. Optimization of a method for determination of phenolic acids in exotic fruits by capillary electrophoresis. Journal of Pharmaceutical and Biomedical Analysis 2010, 51 (2) , 430-438. https://doi.org/10.1016/j.jpba.2009.05.014
    94. Jiyang Luo, Chengrui Tian, Jianguo Xu, Ye Sun. Studies on the antioxidant activity and phenolic compounds of enzyme-assisted water extracts from Du-zhong ( Eucommia ulmoides Oliv.) leaves. Journal of Enzyme Inhibition and Medicinal Chemistry 2009, 24 (6) , 1280-1287. https://doi.org/10.3109/14756360902829741
    95. Ryszard Amarowicz, Reinhold Carle, Gerhard Dongowski, Alessandra Durazzo, Rudolf Galensa, Dietmar Kammerer, Guiseppe Maiani, Mariusz K. Piskula. Influence of postharvest processing and storage on the content of phenolic acids and flavonoids in foods. Molecular Nutrition & Food Research 2009, 53 (S2) https://doi.org/10.1002/mnfr.200700486
    96. Lunzhao Yi, Yizeng Liang, Hai Wu, Dalin Yuan. The analysis of Radix Angelicae Sinensis (Danggui). Journal of Chromatography A 2009, 1216 (11) , 1991-2001. https://doi.org/10.1016/j.chroma.2008.07.033
    97. Maureen McKenzie, Carl Li, Peter B. Kaufman, E. Mitchell Seymour, Ara Kirakosyan. The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression. 2009, 231-287. https://doi.org/10.1007/978-1-4419-0194-1_11
    98. Jiří Gruz, Ondřej Novák, Miroslav Strnad. Rapid analysis of phenolic acids in beverages by UPLC–MS/MS. Food Chemistry 2008, 111 (3) , 789-794. https://doi.org/10.1016/j.foodchem.2008.05.014
    99. Guihua Xu, Xingqian Ye, Donghong Liu, Yaqin Ma, Jianchu Chen. Composition and distribution of phenolic acids in Ponkan (Citrus poonensis Hort. ex Tanaka) and Huyou (Citrus paradisi Macf. Changshanhuyou) during maturity. Journal of Food Composition and Analysis 2008, 21 (5) , 382-389. https://doi.org/10.1016/j.jfca.2008.03.003
    100. Aurora Navas Díaz, Manuel Algarra, Lorenzo Sánchez Feria, Francisco García Sánchez. Fluorimetric Determination of p -Hydroxybenzoic Acid in Beer as α -Cyclodextrin Inclusion Complex. Analytical Letters 2008, 41 (10) , 1802-1810. https://doi.org/10.1080/00032710802162368
    Load all citations

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    MENDELEY PAIRING EXPIRED
    Your Mendeley pairing has expired. Please reconnect