Bioavailability of Anthocyanins from Purple Carrot Juice: Effects of Acylation and Plant Matrix
- Craig S. Charron
- ,
- Anne C. Kurilich
- ,
- Beverly A. Clevidence
- ,
- Philipp W. Simon
- ,
- Dawn J. Harrison
- ,
- Steven J. Britz
- ,
- David J. Baer
- , and
- Janet A. Novotny
Abstract
Absorption of cyanidin-based anthocyanins is not fully understood with respect to dose or anthocyanin structure. In feeding studies using whole foods, nonacylated anthocyanins are more bioavailable than their acylated counterparts, but the extent to which plant matrix determines relative bioavailability of anthocyanins is unknown. Using juice of purple carrots to circumvent matrix effects, a feeding trial was conducted to determine relative bioavailability of acylated and nonacylated anthocyanins and to assess dose−response effects. Appearance of anthocyanins in plasma was measured in 10 healthy adults for 8 h following consumption of purple carrot juice. Each subject consumed 50, 150, and 250 mL of juice containing 76 μmol (65 mg), 228 μmol (194 mg), and 380 μmol (323 mg) of total anthocyanins, respectively. Acylated anthocyanins comprised 76% of total anthocyanins in the juice, yet their bioavailability was found to be significantly less than that of nonacylated anthocyanins. Peak plasma concentrations of nonacylated anthocyanins were 4-fold higher than that for acylated anthocyanins. Absorption efficiency declined across the doses administered. Because the treatments were consumed as juice, it could be discerned that the difference in bioavailability of acylated versus nonacylated anthocyanins was not primarily caused by interactions with the plant matrix.
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- Amandeep K. Sandhu, Yancui Huang, Di Xiao, Eunyoung Park, Indika Edirisinghe, and Britt Burton-Freeman . Pharmacokinetic Characterization and Bioavailability of Strawberry Anthocyanins Relative to Meal Intake. Journal of Agricultural and Food Chemistry 2016, 64 (24) , 4891-4899. https://doi.org/10.1021/acs.jafc.6b00805
- Mary H. Grace, Debora Esposito, Kriya L. Dunlap, and Mary Ann Lila . Comparative Analysis of Phenolic Content and Profile, Antioxidant Capacity, and Anti-inflammatory Bioactivity in Wild Alaskan and Commercial Vaccinium Berries. Journal of Agricultural and Food Chemistry 2014, 62 (18) , 4007-4017. https://doi.org/10.1021/jf403810y
- Jim Fang . Some Anthocyanins Could Be Efficiently Absorbed across the Gastrointestinal Mucosa: Extensive Presystemic Metabolism Reduces Apparent Bioavailability. Journal of Agricultural and Food Chemistry 2014, 62 (18) , 3904-3911. https://doi.org/10.1021/jf405356b
- Mary Ann Lila, David M. Ribnicky, Leonel E. Rojo, Patricio Rojas-Silva, Andrew Oren, Robert Havenaar, Elsa M. Janle, Ilya Raskin, Gad G. Yousef, and Mary H. Grace . Complementary Approaches To Gauge the Bioavailability and Distribution of Ingested Berry Polyphenolics. Journal of Agricultural and Food Chemistry 2012, 60 (23) , 5763-5771. https://doi.org/10.1021/jf203526h
- Janet A. Novotny . Anthocyanin Bioavailability: Past Progress and Current Challenges. 2012, 559-568. https://doi.org/10.1021/bk-2012-1093.ch032
- Wieslaw Wiczkowski, Ewa Romaszko, and Mariusz K. Piskula . Bioavailability of Cyanidin Glycosides from Natural Chokeberry (Aronia melanocarpa) Juice with Dietary-Relevant Dose of Anthocyanins in Humans. Journal of Agricultural and Food Chemistry 2010, 58 (23) , 12130-12136. https://doi.org/10.1021/jf102979z
- Sara A. Arscott, Philipp W. Simon and Sherry A. Tanumihardjo . Anthocyanins in Purple−Orange Carrots (Daucus carota L.) Do Not Influence the Bioavailability of β-Carotene in Young Women. Journal of Agricultural and Food Chemistry 2010, 58 (5) , 2877-2881. https://doi.org/10.1021/jf9041326
- Zahra Foroutani, Mohammad Reza Afshar Mogaddam, Zahra Ghasempour, Nazila Ghareaghajlou. Application of deep eutectic solvents in the extraction of anthocyanins: Stability, bioavailability, and antioxidant property. Trends in Food Science & Technology 2024, 144 , 104324. https://doi.org/10.1016/j.tifs.2023.104324
- Amanda Lais Alves Almeida Nascimento, Larissa Lorrane Rodrigues Borges, Janaina Gonçalves Fernandes, Valdeir Viana Freitas, Evandro Martins, Pedro Henrique Campelo, Paulo Cesar Stringheta. Exploring strategies to enhance anthocyanin bioavailability and bioaccessibility in food: A literature review. Food Bioscience 2023, 56 , 103388. https://doi.org/10.1016/j.fbio.2023.103388
- Wenfeng Li, Wanjie Zhang, Xin Fan, Hai Xu, Hong Yuan, Yimeng Wang, Rui Yang, Hua Tian, Yinmei Wu, Hongyan Yang. Fructo-oligosaccharide enhanced bioavailability of polyglycosylated anthocyanins from red radish via regulating gut microbiota in mice. Food Chemistry: X 2023, 19 , 100765. https://doi.org/10.1016/j.fochx.2023.100765
- Eun Ha Lee, Sung-Chul Hong, Sang Min Kim, Cheol-Ho Pan. Inhibitory effect of anthocyanin-enriched fractions from colored potatoes against lipase and α-glucosidase. LWT 2023, 184 , 114952. https://doi.org/10.1016/j.lwt.2023.114952
- Connie M. Weaver, Mario G. Ferruzzi, Maria Maiz, Dennis P. Cladis, Cindy H. Nakatsu, George P. McCabe, Mary Ann Lila. Crop, Host, and Gut Microbiome Variation Influence Precision Nutrition: An Example of Blueberries. Antioxidants 2023, 12 (5) , 1136. https://doi.org/10.3390/antiox12051136
- María Belén Pérez, Sofía Carvajal, Vanesa Beretta, Florencia Bannoud, María Florencia Fangio, Federico Berli, Ariel Fontana, María Victoria Salomón, Roxana Gonzalez, Lucia Valerga, Jorgelina C. Altamirano, Mehtap Yildiz, Massimo Iorizzo, Philipp W. Simon, Pablo F. Cavagnaro. Characterization of Purple Carrot Germplasm for Antioxidant Capacity and Root Concentration of Anthocyanins, Phenolics, and Carotenoids. Plants 2023, 12 (9) , 1796. https://doi.org/10.3390/plants12091796
- Pablo F. Cavagnaro, Frank Dunemann, Raman Selvakumar, Massimo Iorizzo, Philipp W. Simon. Health-Enhancing Compounds in Carrots: Genetics, Genomics, and Molecular Breeding. 2023, 1-72. https://doi.org/10.1007/978-981-19-3627-2_51-1
- Pritam Kalia, Raman Selvakumar. Root Vegetables for Nutrition and Entrepreneurship. 2023, 481-532. https://doi.org/10.1007/978-981-19-9016-8_22
- Pablo F. Cavagnaro, Frank Dunemann, Raman Selvakumar, Massimo Iorizzo, Philipp W. Simon. Health-Enhancing Compounds in Carrots: Genetics, Genomics, and Molecular Breeding. 2023, 1365-1435. https://doi.org/10.1007/978-981-19-4169-6_51
- Haochen Dai, Adam Forbes, Xin Guo, Lili He. Prediction of Anthocyanin Color Stability against Iron Co-Pigmentation by Surface-Enhanced Raman Spectroscopy. Foods 2022, 11 (21) , 3436. https://doi.org/10.3390/foods11213436
- Raman Selvakumar, Pritam Kalia, Dalasanuru Chandregowda Manjunathagowda, R. S. Raje. Inheritance of purple colour and its different flavonoids profiling in F2 populations of tropical carrot (Daucus carota L.). Genetic Resources and Crop Evolution 2022, 69 (7) , 2413-2423. https://doi.org/10.1007/s10722-022-01380-z
- Molla Fentie Mengist, Mary H. Grace, Ted Mackey, Bryan Munoz, Boas Pucker, Nahla Bassil, Claire Luby, Mario Ferruzzi, Mary Ann Lila, Massimo Iorizzo. Dissecting the genetic basis of bioactive metabolites and fruit quality traits in blueberries (Vaccinium corymbosum L.). Frontiers in Plant Science 2022, 13 https://doi.org/10.3389/fpls.2022.964656
- Dina M. El-Kersh, Rania F. Abou El-Ezz, Marwa Fouad, Mohamed A. Farag. Unveiling Natural and Semisynthetic Acylated Flavonoids: Chemistry and Biological Actions in the Context of Molecular Docking. Molecules 2022, 27 (17) , 5501. https://doi.org/10.3390/molecules27175501
- Jingren He, Shuxin Ye, Patrícia Correia, Iva Fernandes, Rui Zhang, Muci Wu, Victor Freitas, Nuno Mateus, Hélder Oliveira. Dietary polyglycosylated anthocyanins, the smart option? A comprehensive review on their health benefits and technological applications. Comprehensive Reviews in Food Science and Food Safety 2022, 21 (4) , 3096-3128. https://doi.org/10.1111/1541-4337.12970
- Aynur Müdüroğlu Kırmızıbekmez, İhsan Kara. Dietary Components Consisting of Bioactive Molecules in the Prevention of Neurodegenerative Diseases. 2022, 73-100. https://doi.org/10.4018/978-1-6684-5129-8.ch005
- Gesyane Bentos França, Mayara Schueroff Siqueira, Jean Carlos de Souza Melo, Danusia Tavares de Albuquerque, Francine Perri Venturini, Claucia Aparecida Honorato. HYDROALCOHOLIC EXTRACT OF JABUTICABA BARK IN FEMALE BETTA FISH DIET. Boletim do Instituto de Pesca 2022, 48 https://doi.org/10.20950/1678-2305/bip.2022.48.e659
- Yanjie Zhang, Qing Zhao, Youwei Feng, Yuanhang Dong, Tianjiao Zhang, Qiu Yang, Huihui Gu, Jinyong Huang, Yan Li. Integrated Transcriptomic and Metabolomic Analyses Reveal the Mechanisms Underlying Anthocyanin Coloration and Aroma Formation in Purple Fennel. Frontiers in Nutrition 2022, 9 https://doi.org/10.3389/fnut.2022.875360
- Ruth Hornedo-Ortega, Zuriñe Rasines-Perea, Ana B. Cerezo, Pierre-Louis Teissedre, Michael Jourdes. Anthocyanins: Dietary Sources, Bioavailability, Human Metabolic Pathways, and Potential Anti-Neuroinflammatory Activity. 2022https://doi.org/10.5772/intechopen.99927
- Takashi Ichiyanagi, Masayuki Nashimoto, Hiroki Hayashi, Norihiko Terahara. Effect of Acylated Sugar Moieties on Gastrointestinal Absorption of Mono-Acylated Anthocyanins in Rats. BPB Reports 2022, 5 (3) , 24-32. https://doi.org/10.1248/bpbreports.5.3_24
- Vimbainashe E. Manhivi, Retha M. Slabbert, Dharini Sivakumar. Co-Ingestion of Natal Plums (Carissa macrocarpa) and Marula Nuts (Sclerocarya birrea) in a Snack Bar and Its Effect on Phenolic Compounds and Bioactivities. Molecules 2022, 27 (1) , 310. https://doi.org/10.3390/molecules27010310
- Avinash Karn, Luis Diaz-Garcia, Noam Reshef, Cheng Zou, David C. Manns, Lance Cadle-Davidson, Anna Katharine Mansfield, Bruce I. Reisch, Gavin L. Sacks. The Genetic Basis of Anthocyanin Acylation in North American Grapes (Vitis spp.). Genes 2021, 12 (12) , 1962. https://doi.org/10.3390/genes12121962
- Johanna Jokioja, Baoru Yang, Kaisa M. Linderborg. Acylated anthocyanins: A review on their bioavailability and effects on postprandial carbohydrate metabolism and inflammation. Comprehensive Reviews in Food Science and Food Safety 2021, 20 (6) , 5570-5615. https://doi.org/10.1111/1541-4337.12836
- Hasan Tanguler, Adnan Bozdogan, Salih Aksay, Hasim Kelebek, Huseyin Erten. Comparison of anthocyanin profiles in şalgams (shalgams) produced with different production procedures. Journal of Food Processing and Preservation 2021, 45 (8) https://doi.org/10.1111/jfpp.14770
- Angela R. Hillman, Kathy Uhranowsky. Acute Ingestion of Montmorency Tart Cherry Reduces Serum Uric Acid but Has no Impact on High Sensitivity C-Reactive Protein or Oxidative Capacity. Plant Foods for Human Nutrition 2021, 76 (1) , 83-89. https://doi.org/10.1007/s11130-021-00879-7
- Bin Li, Li Wang, Weibin Bai, Wei Chen, Fang Chen, Chi Shu. Bioavailability and Bioabsorption of Anthocyanins. 2021, 95-113. https://doi.org/10.1007/978-981-16-7055-8_5
- Fabio Sciubba, Alberta Tomassini, Giorgio Giorgi, Elisa Brasili, Gabriella Pasqua, Giorgio Capuani, Walter Aureli, Alfredo Miccheli. NMR-Based Metabolomic Study of Purple Carrot Optimal Harvest Time for Utilization as a Source of Bioactive Compounds. Applied Sciences 2020, 10 (23) , 8493. https://doi.org/10.3390/app10238493
- Celia Carrillo, Senem Kamiloglu, Charlotte Grootaert, John Van Camp, Marc Hendrickx. Co-Ingestion of Black Carrot and Strawberry. Effects on Anthocyanin Stability, Bioaccessibility and Uptake. Foods 2020, 9 (11) , 1595. https://doi.org/10.3390/foods9111595
- Ruirui Gao, Philip D. Chilibeck. Effect of Tart Cherry Concentrate on Endurance Exercise Performance: A Meta-analysis. Journal of the American College of Nutrition 2020, 39 (7) , 657-664. https://doi.org/10.1080/07315724.2020.1713246
- Luana Izzo, Yelko Rodríguez-Carrasco, Severina Pacifico, Luigi Castaldo, Alfonso Narváez, Alberto Ritieni. Colon Bioaccessibility under In Vitro Gastrointestinal Digestion of a Red Cabbage Extract Chemically Profiled through UHPLC-Q-Orbitrap HRMS. Antioxidants 2020, 9 (10) , 955. https://doi.org/10.3390/antiox9100955
- Alyssa Francavilla, Iris J. Joye. Anthocyanins in Whole Grain Cereals and Their Potential Effect on Health. Nutrients 2020, 12 (10) , 2922. https://doi.org/10.3390/nu12102922
- Roberto Mattioli, Antonio Francioso, Luciana Mosca, Paula Silva. Anthocyanins: A Comprehensive Review of Their Chemical Properties and Health Effects on Cardiovascular and Neurodegenerative Diseases. Molecules 2020, 25 (17) , 3809. https://doi.org/10.3390/molecules25173809
- Hélder Oliveira, Ana Fernandes, Natércia F. Brás, Nuno Mateus, Victor de Freitas, Iva Fernandes. Anthocyanins as Antidiabetic Agents—In Vitro and In Silico Approaches of Preventive and Therapeutic Effects. Molecules 2020, 25 (17) , 3813. https://doi.org/10.3390/molecules25173813
- Massimo Iorizzo, Julien Curaba, Marti Pottorff, Mario G. Ferruzzi, Philipp Simon, Pablo F. Cavagnaro. Carrot Anthocyanins Genetics and Genomics: Status and Perspectives to Improve Its Application for the Food Colorant Industry. Genes 2020, 11 (8) , 906. https://doi.org/10.3390/genes11080906
- Molla F. Mengist, Mary H. Grace, Jia Xiong, Colin D. Kay, Nahla Bassil, Kim Hummer, Mario G. Ferruzzi, Mary Ann Lila, Massimo Iorizzo. Diversity in Metabolites and Fruit Quality Traits in Blueberry Enables Ploidy and Species Differentiation and Establishes a Strategy for Future Genetic Studies. Frontiers in Plant Science 2020, 11 https://doi.org/10.3389/fpls.2020.00370
- Julien Curaba, Hamed Bostan, Pablo F. Cavagnaro, Douglas Senalik, Molla Fentie Mengist, Yunyang Zhao, Philipp W. Simon, Massimo Iorizzo. Identification of an SCPL Gene Controlling Anthocyanin Acylation in Carrot (Daucus carota L.) Root. Frontiers in Plant Science 2020, 10 https://doi.org/10.3389/fpls.2019.01770
- Rasika Hudlikar, Renyi Wu, David Cheng, Dina Hsiao-Chen Kuo, Lujing Wang, Rebecca Peter, Ran Yin, Shanyi Li, Ah-Ng Kong. Anthocyanins and Cancer Prevention. 2020, 351-373. https://doi.org/10.1007/978-3-030-39855-2_11
- Ji-Li Fang, Yang Luo, Ke Yuan, Ying Guo, Song-Heng Jin. Preparation and evaluation of an encapsulated anthocyanin complex for enhancing the stability of anthocyanin. LWT 2020, 117 , 108543. https://doi.org/10.1016/j.lwt.2019.108543
- Merve Eda Eker, Kjersti Aaby, Irena Budic-Leto, Suzana Rimac Brnčić, Sedef Nehir El, Sibel Karakaya, Sebnem Simsek, Claudine Manach, Wieslaw Wiczkowski, Sonia de Pascual-Teresa. A Review of Factors Affecting Anthocyanin Bioavailability: Possible Implications for the Inter-Individual Variability. Foods 2020, 9 (1) , 2. https://doi.org/10.3390/foods9010002
- P.F. Cavagnaro, F. Bannoud, M. Iorizzo, D. Senalik, S.L. Ellison, P.W. Simon. Carrot anthocyanins: nutrition, diversity and genetics. Acta Horticulturae 2019, 33 (1264) , 101-106. https://doi.org/10.17660/ActaHortic.2019.1264.11
- Wilhelmina Kalt. Anthocyanins and Their C6-C3-C6 Metabolites in Humans and Animals. Molecules 2019, 24 (22) , 4024. https://doi.org/10.3390/molecules24224024
- Florencia Bannoud, Shelby Ellison, Marcos Paolinelli, Thomas Horejsi, Douglas Senalik, Martín Fanzone, Massimo Iorizzo, Philipp W. Simon, Pablo F. Cavagnaro. Dissecting the genetic control of root and leaf tissue-specific anthocyanin pigmentation in carrot (Daucus carota L.). Theoretical and Applied Genetics 2019, 132 (9) , 2485-2507. https://doi.org/10.1007/s00122-019-03366-5
- Ayaka Tsutsumi, Yukari Horikoshi, Taiki Fushimi, Akiko Saito, Ryo Koizumi, Yasuyuki Fujii, Qing Qiang Hu, Yoshihisa Hirota, Koichi Aizawa, Naomi Osakabe. Acylated anthocyanins derived from purple carrot ( Daucus carota L.) induce elevation of blood flow in rat cremaster arteriole. Food & Function 2019, 10 (3) , 1726-1735. https://doi.org/10.1039/C8FO02125B
- Massimo Iorizzo, Pablo F. Cavagnaro, Hamed Bostan, Yunyang Zhao, Jianhui Zhang, Philipp W. Simon. A Cluster of MYB Transcription Factors Regulates Anthocyanin Biosynthesis in Carrot (Daucus carota L.) Root and Petiole. Frontiers in Plant Science 2019, 9 https://doi.org/10.3389/fpls.2018.01927
- Pablo F. Cavagnaro, Massimo Iorizzo. Carrot Anthocyanin Diversity, Genetics, and Genomics. 2019, 261-277. https://doi.org/10.1007/978-3-030-03389-7_15
- Carlo Barnaba, Ilce G. Medina-Meza. Flavonoids Ability to Disrupt Inflammation Mediated by Lipid and Cholesterol Oxidation. 2019, 243-253. https://doi.org/10.1007/978-3-030-21735-8_19
- Iva Fernandes, Cláudia Marques, Ana Évora, Ana Faria, Conceição Calhau, Nuno Mateus, Victor de Freitas. Anthocyanins: Nutrition and Health. 2019, 1097-1133. https://doi.org/10.1007/978-3-319-78030-6_79
- Feng Wang, Guang-Long Wang, Xi-Lin Hou, Meng-Yao Li, Zhi-Sheng Xu, Ai-Sheng Xiong. The genome sequence of ‘Kurodagosun’, a major carrot variety in Japan and China, reveals insights into biological research and carrot breeding. Molecular Genetics and Genomics 2018, 293 (4) , 861-871. https://doi.org/10.1007/s00438-018-1428-3
- Yelfira Sari, Adlis Santoni, Elisabet Elisabet. Comparative Test of Color Stability between Betalain Pigments of Red Dragon Fruits and Anthocyanin Pigments from Tamarillo Fruit at Various pH. Jurnal Kimia Sains dan Aplikasi 2018, 21 (3) , 107-112. https://doi.org/10.14710/jksa.21.3.107-112
- Anna Rafaela Cavalcante Braga, Daniella Carisa Murador, Leonardo Mendes de Souza Mesquita, Veridiana Vera de Rosso. Bioavailability of anthocyanins: Gaps in knowledge, challenges and future research. Journal of Food Composition and Analysis 2018, 68 , 31-40. https://doi.org/10.1016/j.jfca.2017.07.031
- Senem Kamiloglu, John Van Camp, Esra Capanoglu. Black carrot polyphenols: effect of processing, storage and digestion—an overview. Phytochemistry Reviews 2018, 17 (2) , 379-395. https://doi.org/10.1007/s11101-017-9539-8
- Glaucia Resende Soares, Carolina Foot Gomes de Moura, Marcelo Jose Dias Silva, Wagner Vilegas, Aline Boveto Santamarina, Luciana Pellegrini Pisani, Debora Estadella, Daniel Araki Ribeiro. Protective effects of purple carrot extract (Daucus carota) against rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. Medical Oncology 2018, 35 (4) https://doi.org/10.1007/s12032-018-1114-7
- Iva Fernandes, Cláudia Marques, Ana Évora, Ana Faria, Conceição Calhau, Nuno Mateus, Victor de Freitas. Anthocyanins: Nutrition and Health. 2018, 1-37. https://doi.org/10.1007/978-3-319-54528-8_79-1
- Siqiong Zhong, Amandeep Sandhu, Indika Edirisinghe, Britt Burton‐Freeman. Characterization of Wild Blueberry Polyphenols Bioavailability and Kinetic Profile in Plasma over 24‐h Period in Human Subjects. Molecular Nutrition & Food Research 2017, 61 (12) https://doi.org/10.1002/mnfr.201700405
- Hala M. Ayoub, Mary Ruth McDonald, James Alan Sullivan, Rong Tsao, Mathew Platt, Jeremy Simpson, Kelly A. Meckling. The Effect of Anthocyanin-Rich Purple Vegetable Diets on Metabolic Syndrome in Obese Zucker Rats. Journal of Medicinal Food 2017, 20 (12) , 1240-1249. https://doi.org/10.1089/jmf.2017.0025
- Giovana Bonat Celli, Amyl Ghanem, Marianne Su-Ling Brooks. A theoretical physiologically based pharmacokinetic approach for modeling the fate of anthocyanins in vivo. Critical Reviews in Food Science and Nutrition 2017, 57 (15) , 3197-3207. https://doi.org/10.1080/10408398.2015.1104290
- Giovana Bonat Celli, Marianne Su-Ling Brooks. Impact of extraction and processing conditions on betalains and comparison of properties with anthocyanins — A current review. Food Research International 2017, 100 , 501-509. https://doi.org/10.1016/j.foodres.2016.08.034
- Saeed Akhtar, Abdur Rauf, Muhammad Imran, Muhammad Qamar, Muhammad Riaz, Mohammad S. Mubarak. Black carrot ( Daucus carota L.), dietary and health promoting perspectives of its polyphenols: A review. Trends in Food Science & Technology 2017, 66 , 36-47. https://doi.org/10.1016/j.tifs.2017.05.004
- Celia Carrillo, Carolien Buvé, Agnese Panozzo, Tara Grauwet, Marc Hendrickx. Role of structural barriers in the in vitro bioaccessibility of anthocyanins in comparison with carotenoids. Food Chemistry 2017, 227 , 271-279. https://doi.org/10.1016/j.foodchem.2017.01.062
- John Overall, Mary Ann Lila, Slavko Komarnytsky. Anthocyanins in metabolic health and disease. 2017, 92-124. https://doi.org/10.1002/9781119101277.ch5
- Senem Kamiloglu, Charlotte Grootaert, Esra Capanoglu, Ceren Ozkan, Guy Smagghe, Katleen Raes, John Van Camp. Anti‐inflammatory potential of black carrot ( Daucus carota L.) polyphenols in a co‐culture model of intestinal Caco‐2 and endothelial EA.hy926 cells. Molecular Nutrition & Food Research 2017, 61 (2) https://doi.org/10.1002/mnfr.201600455
- Cansu Pala, Canan Sevimli-Gur, Ozlem Yesil-Celiktas. Green Extraction Processes Focusing on Maximization of Black Carrot Anthocyanins along with Cytotoxic Activities. Food Analytical Methods 2017, 10 (2) , 529-538. https://doi.org/10.1007/s12161-016-0599-y
- John Overall, Sierra Bonney, Mickey Wilson, Arnold Beermann, Mary Grace, Debora Esposito, Mary Lila, Slavko Komarnytsky. Metabolic Effects of Berries with Structurally Diverse Anthocyanins. International Journal of Molecular Sciences 2017, 18 (2) , 422. https://doi.org/10.3390/ijms18020422
- Sepideh Hosseini, Maryam Gharachorloo, Babak Ghiassi-Tarzi, Mehrdad Ghavami. Evaluation the Organic Acids Ability for Extraction of Anthocyanins and Phenolic Compounds from different sources and Their Degradation Kinetics during Cold Storage. Polish Journal of Food and Nutrition Sciences 2016, 66 (4) , 261-269. https://doi.org/10.1515/pjfns-2015-0057
- Nurcan Değirmencioğlu, Ozan Gurbuz, Yasemin Şahan. The Monitoring, Via an In vitro Digestion System, of the Bioactive Content of Vegetable Juice Fermented with Saccharomyces cerevisiae and Saccharomyces boulardii. Journal of Food Processing and Preservation 2016, 40 (4) , 798-811. https://doi.org/10.1111/jfpp.12704
- Giovana Bonat Celli, Wilhelmina Kalt, Marianne Su-Ling Brooks. Gastroretentive systems – a proposed strategy to modulate anthocyanin release and absorption for the management of diabetes. Drug Delivery 2016, 23 (6) , 1892-1901. https://doi.org/10.3109/10717544.2016.1143058
- Jamie I. Baum, Luke R. Howard, Ronald L. Prior, Sun-Ok Lee, , . Effect of Aronia melanocarpa (Black Chokeberry) supplementation on the development of obesity in mice fed a high-fat diet. Journal of Berry Research 2016, 6 (2) , 203-212. https://doi.org/10.3233/JBR-160134
- Wieslaw Wiczkowski, Dorota Szawara-Nowak, Jerzy Romaszko. The impact of red cabbage fermentation on bioavailability of anthocyanins and antioxidant capacity of human plasma. Food Chemistry 2016, 190 , 730-740. https://doi.org/10.1016/j.foodchem.2015.06.021
- Anna Olejnik, Joanna Rychlik, Marcin Kidoń, Janusz Czapski, Katarzyna Kowalska, Wojciech Juzwa, Mariola Olkowicz, Radosław Dembczyński, Mary Pat Moyer. Antioxidant effects of gastrointestinal digested purple carrot extract on the human cells of colonic mucosa. Food Chemistry 2016, 190 , 1069-1077. https://doi.org/10.1016/j.foodchem.2015.06.080
- Anna Olejnik, Katarzyna Kowalska, Marcin Kidoń, Janusz Czapski, Joanna Rychlik, Mariola Olkowicz, Radosław Dembczyński. Purple carrot anthocyanins suppress lipopolysaccharide-induced inflammation in the co-culture of intestinal Caco-2 and macrophage RAW264.7 cells. Food & Function 2016, 7 (1) , 557-564. https://doi.org/10.1039/C5FO00890E
- Iva Fernandes, Ana Faria, Victor de Freitas, Conceição Calhau, Nuno Mateus. Multiple-approach studies to assess anthocyanin bioavailability. Phytochemistry Reviews 2015, 14 (6) , 899-919. https://doi.org/10.1007/s11101-015-9415-3
- Senem Kamiloglu, Esra Capanoglu, Charlotte Grootaert, John Van Camp. Anthocyanin Absorption and Metabolism by Human Intestinal Caco-2 Cells—A Review. International Journal of Molecular Sciences 2015, 16 (9) , 21555-21574. https://doi.org/10.3390/ijms160921555
- Senem Kamiloglu, Ayca Ayfer Pasli, Beraat Ozcelik, John Van Camp, Esra Capanoglu. Colour retention, anthocyanin stability and antioxidant capacity in black carrot (Daucus carota) jams and marmalades: Effect of processing, storage conditions and in vitro gastrointestinal digestion. Journal of Functional Foods 2015, 13 , 1-10. https://doi.org/10.1016/j.jff.2014.12.021
- Chang Tian, Qian Jiang, Feng Wang, Guang-Long Wang, Zhi-Sheng Xu, Ai-Sheng Xiong, . Selection of Suitable Reference Genes for qPCR Normalization under Abiotic Stresses and Hormone Stimuli in Carrot Leaves. PLOS ONE 2015, 10 (2) , e0117569. https://doi.org/10.1371/journal.pone.0117569
- Pablo F Cavagnaro, Massimo Iorizzo, Mehtap Yildiz, Douglas Senalik, Joshua Parsons, Shelby Ellison, Philipp W Simon. A gene-derived SNP-based high resolution linkage map of carrot including the location of QTL conditioning root and leaf anthocyanin pigmentation. BMC Genomics 2014, 15 (1) https://doi.org/10.1186/1471-2164-15-1118
- Phillip G. Bell, David C. Gaze, Gareth W. Davison, Trevor W. George, Michael J. Scotter, Glyn Howatson. Montmorency tart cherry (Prunus cerasus L.) concentrate lowers uric acid, independent of plasma cyanidin-3-O-glucosiderutinoside. Journal of Functional Foods 2014, 11 , 82-90. https://doi.org/10.1016/j.jff.2014.09.004
- Jim Fang. Bioavailability of anthocyanins. Drug Metabolism Reviews 2014, 46 (4) , 508-520. https://doi.org/10.3109/03602532.2014.978080
- Carolina Fredes, Gad G Yousef, Paz Robert, Mary H Grace, Mary Ann Lila, Miguel Gómez, Marlene Gebauer, Gloria Montenegro. Anthocyanin profiling of wild maqui berries ( Aristotelia chilensis [Mol.] Stuntz) from different geographical regions in Chile. Journal of the Science of Food and Agriculture 2014, 94 (13) , 2639-2648. https://doi.org/10.1002/jsfa.6602
- Xin Jin, Mingliang Chen, Long Yi, Hui Chang, Ting Zhang, Li Wang, Wanqiang Ma, Xiaoli Peng, Yong Zhou, Mantian Mi. Delphinidin‐3‐glucoside protects human umbilical vein endothelial cells against oxidized low‐density lipoprotein‐induced injury by autophagy upregulation via the AMPK/SIRT1 signaling pathway. Molecular Nutrition & Food Research 2014, 58 (10) , 1941-1951. https://doi.org/10.1002/mnfr.201400161
- Jungmin Lee, Michael Dossett, Chad Finn. Mistaken Identity: Clarification of Rubus coreanus Miquel (Bokbunja). Molecules 2014, 19 (7) , 10524-10533. https://doi.org/10.3390/molecules190710524
- M.T.M. Assous, M.M. Abdel-Hady, Ghada M. Medany. Evaluation of red pigment extracted from purple carrots and its utilization as antioxidant and natural food colorants. Annals of Agricultural Sciences 2014, 59 (1) , 1-7. https://doi.org/10.1016/j.aoas.2014.06.001
- P. G. Bell, M. P. McHugh, E. Stevenson, G. Howatson. The role of cherries in exercise and health. Scandinavian Journal of Medicine & Science in Sports 2014, 24 (3) , 477-490. https://doi.org/10.1111/sms.12085
- Yixiang Liu, Di Zhang, Yongpei Wu, Dan Wang, Ying Wei, Jiulin Wu, Baoping Ji. Stability and absorption of anthocyanins from blueberries subjected to a simulated digestion process. International Journal of Food Sciences and Nutrition 2014, 65 (4) , 440-448. https://doi.org/10.3109/09637486.2013.869798
- Gad G. Yousef, Mary A. Lila, Ivette Guzman, James R. Ballington, Allan F. Brown. Impact of Interspecific Introgression on Anthocyanin Profiles of Southern Highbush Blueberry. Journal of the American Society for Horticultural Science 2014, 139 (2) , 99-112. https://doi.org/10.21273/JASHS.139.2.99
- Phillip Bell, Ian Walshe, Gareth Davison, Emma Stevenson, Glyn Howatson. Montmorency Cherries Reduce the Oxidative Stress and Inflammatory Responses to Repeated Days High-Intensity Stochastic Cycling. Nutrients 2014, 6 (2) , 829-843. https://doi.org/10.3390/nu6020829
- M. J. Akhtar, M. Jacquot, S. Desobry. Effect of HPMC–Anthocyanin Packaging Color and Oxygen Permeability on Salmon Oil Preservation. Food and Bioprocess Technology 2014, 7 (1) , 93-104. https://doi.org/10.1007/s11947-013-1075-y
- Angélique Stalmach. Bioavailability of Dietary Anthocyanins and Hydroxycinnamic Acids. 2014, 561-576. https://doi.org/10.1016/B978-0-12-398456-2.00042-6
- Giulia Corona, David Vauzour, Anna Amini, Jeremy P.E. Spencer. The Impact of Gastrointestinal Modifications, Blood-Brain Barrier Transport, and Intracellular Metabolism on Polyphenol Bioavailability. 2014, 591-604. https://doi.org/10.1016/B978-0-12-398456-2.00044-X
- Vasil Georgiev, Anthony Ananga, Violeta Tsolova. Recent Advances and Uses of Grape Flavonoids as Nutraceuticals. Nutrients 2014, 6 (1) , 391-415. https://doi.org/10.3390/nu6010391
- Fangli Hou, Ruifen Zhang, Mingwei Zhang, Dongxiao Su, Zhencheng Wei, Yuanyuan Deng, Yan Zhang, Jianwei Chi, Xiaojun Tang. Hepatoprotective and antioxidant activity of anthocyanins in black rice bran on carbon tetrachloride-induced liver injury in mice. Journal of Functional Foods 2013, 5 (4) , 1705-1713. https://doi.org/10.1016/j.jff.2013.07.015
- Pu Jing, M Giusti. Analysis of Anthocyanins in Biological Samples. 2013, 115-140. https://doi.org/10.1201/b15554-5
- Rosalind Miller, Sophie Putnam, Michael Edwards, Gary Woodward, Colin Kay. Potential Health Benefits of Blackcurrants. 2013, 215-250. https://doi.org/10.1002/9781118635551.ch10
- Olivia R.L. Wright, Gabriele A. Netzel, Amy R. Sakzewski. A randomized, double-blind, placebo-controlled trial of the effect of dried purple carrot on body mass, lipids, blood pressure, body composition, and inflammatory markers in overweight and obese adults: The QUENCH Trial. Canadian Journal of Physiology and Pharmacology 2013, 91 (6) , 480-488. https://doi.org/10.1139/cjpp-2012-0349