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Lipid Bilayer Deposition and Patterning via Air Bubble Collapse

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Department of Materials Science and Engineering, Stanford University, Stanford, California 94305
Cite this: Langmuir 2007, 23, 18, 9369–9377
Publication Date (Web):August 7, 2007
https://doi.org/10.1021/la701372b
Copyright © 2007 American Chemical Society
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    Abstract

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    We report a new method for forming patterned lipid bilayers on solid substrates. In bubble collapse deposition (BCD), an air bubble is first “inked” with a monolayer of phospholipid molecules and then touched to the surface of a thermally oxidized silicon wafer and the air is slowly withdrawn. As the bubble shrinks, the lipid monolayer pressure increases. Once the monolayer exceeds the collapse pressure, it folds back on itself, depositing a stable lipid bilayer on the surface. These bilayer disks have lateral diffusion coefficients consistent with high quality supported bilayers. By sequentially depositing bilayers in overlapping areas, fluid connections between bilayers of different compositions are formed. Performing vesicle rupture on the open substrate surrounding this bilayer patch results in a fluid but spatially isolated bilayer. Very little intermixing was observed between the vesicle rupture and bubble-deposited bilayers.

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     To whom correspondence should be addressed. E-mail:  nmelosh@ stanford.edu.

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    Images and description of the source bilayer; images of an air bubble rapidly adsorbing a lipid monolayer; graph of solutions to the derivation of lipid monolayer pressure; and image of a bilayer that has been deposited on the site of a previously removed bilayer. This material is available free of charge via the Internet at http://pubs.acs.org.

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