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Download Hi-Res ImageDownload to MS-PowerPointCite This:Nano Lett. 2009, 9, 3, 1121-1126
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Highly Efficient Biocompatible Single Silicon Nanowire Electrodes with Functional Biological Pore Channels

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Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California 94551, Department of Chemical Engineering, University of California, Davis, Davis, California 95616, Department of Mechanical Engineering, University of California, Berkeley, Berkeley, California 94720, and School of Natural Sciences, University of California, Merced, Merced, California 95344
* Corresponding author, [email protected]
†Equal contribution.
‡Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory.
§Department of Chemical Engineering, University of California, Davis.
∥Department of Mechanical Engineering, University of California, Berkeley.
⊥School of Natural Sciences, University of California, Merced.
Cite this: Nano Lett. 2009, 9, 3, 1121–1126
Publication Date (Web):February 9, 2009
https://doi.org/10.1021/nl8036504
Copyright © 2009 American Chemical Society
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    Abstract

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    Nanoscale electrodes based on one-dimensional inorganic conductors could possess significant advantages for electrochemical measurements over their macroscopic counterparts in a variety of electrochemical applications. We show that the efficiency of the electrodes constructed of individual highly doped silicon nanowires greatly exceeds the efficiency of flat Si electrodes. Modification of the surfaces of the nanowire electrodes with phospholipid bilayers produces an efficient biocompatible barrier to transport of the solution redox species to the nanoelectrode surface. Incorporating functional α-hemolysin protein pores in the lipid bilayer results in a partial recovery of the Faradic current due to the specific transport through the protein pore. These assemblies represent a robust and versatile platform for building a new generation of highly specific biosensors and nano/bioelectronic devices.

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    Descriptions of materials and methods and electrochemical characterization of the flat silicon electrodes. This material is available free of charge via the Internet at http://pubs.acs.org.

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