Bridging Macro and Nano
One of the most exciting directions for nanoscience and nanotechnology is the coupling of materials systems on different length scales to enable new ways to take advantage of the unique properties of nanoscale materials.
References
This article references 7 other publications.
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1Schrlau, M. G.; Dun, N. J.; Bau, H. H. Cell Electrophysiology with Carbon Nanopipettes ACS Nano 2009, 3, 563– 568Google Scholar1https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BD1MXhsFegtL4%253D&md5=d236f4007e09c99540eb8d8628848554Cell Electrophysiology with Carbon NanopipettesSchrlau, Michael G.; Dun, Nae J.; Bau, Haim H.ACS Nano (2009), 3 (3), 563-568CODEN: ANCAC3; ISSN:1936-0851. (American Chemical Society)The ability to monitor living cell behavior in real time and with high spatial resoln. is vital for advancing our knowledge of cellular machinery and evaluating cellular response to various drugs. Here, we report the development and utilization of carbon-based nanoelectrodes for cell electrophysiol. We employ carbon nanopipettes (CNPs), novel carbon-based nanoprobes which integrate carbon nanopipes into the tips of pulled glass capillaries, to measure elec. signals in the mouse hippocampal cell line HT-22. Using a std. electrophysiol. amplifier in current-clamp mode, we measured the resting membrane potential of cells and their transient membrane response to extracellular pharmacol. agents. In addn. to their superior injection capabilities reported previously, CNPs are capable of multifunctionality, enabling, for example, concurrent intracellular injection and elec. measurements without damaging cells.
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2Mani, V.; Chikkaveeraiah, B. V.; Patel, V.; Gutkind, J. S.; Rusling, J. F. Ultrasensitive Immunosensor for Cancer Biomarker Proteins Using Gold Nanoparticle Film Electrodes and Multienzyme-Particle Amplification ACS Nano 2009, 3, 585– 594Google Scholar2https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BD1MXhvVChtrY%253D&md5=5f711b00d24a9fa8961572db281a3fffUltrasensitive Immunosensor for Cancer Biomarker Proteins Using Gold Nanoparticle Film Electrodes and Multienzyme-Particle AmplificationMani, Vigneshwaran; Chikkaveeraiah, Bhaskara V.; Patel, Vyomesh; Gutkind, J. Silvio; Rusling, James F.ACS Nano (2009), 3 (3), 585-594CODEN: ANCAC3; ISSN:1936-0851. (American Chemical Society)A densely packed gold nanoparticle platform combined with a multiple-enzyme labeled detection antibody-magnetic bead bioconjugate was used as the basis for an ultrasensitive electrochem. immunosensor to detect cancer biomarkers in serum. Sensitivity was greatly amplified by synthesizing magnetic bioconjugates particles contg. 7500 horseradish peroxidase (HRP) labels along with detection antibodies (Ab2) attached to activated carboxyl groups on 1 μm diam. magnetic beads. These sensors had sensitivity of 31.5 μA mL ng-1 and detection limit (DL) of 0.5 pg mL-1 for prostate specific antigen (PSA) in 10 μL of undiluted serum. This represents an ultralow mass DL of 5 fg PSA, 8-fold better than a previously reported carbon nanotube (CNT) forest immunosensor featuring multiple labels on carbon nanotubes, and near or below the normal serum levels of most cancer biomarkers. Measurements of PSA in cell lysates and human serum of cancer patients gave excellent correlations with std. ELISA assays. These easily fabricated AuNP immunosensors show excellent promise for future fabrication of bioelectronic arrays.
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3Matthiesen, J.; Wendt, S.; Hansen, J. Ø.; Madsen, G. K. H.; Lira, E.; Galliker, P.; Vestergaard, E. K.; Schaub, R.; Lægsgaard, E.; Hammer, B. F.et al. Observation of All the Intermediate Steps of a Chemical Reaction on an Oxide Surface by Scanning Tunneling Microscopy ACS Nano 2009, 3, 517– 526Google Scholar3https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BD1MXhs1Slurs%253D&md5=8f76458810bcdc5239eb9ec97a438bd1Observation of All the Intermediate Steps of a Chemical Reaction on an Oxide Surface by Scanning Tunneling MicroscopyMatthiesen, Jesper; Wendt, Stefan; Hansen, Jonas O.; Madsen, Georg K. H.; Lira, Estephania; Galliker, Patrick; Vestergaard, Ebbe K.; Schaub, Renald; Laegsgaard, Erik; Hammer, Bjork; Besenbacher, FlemmingACS Nano (2009), 3 (3), 517-526CODEN: ANCAC3; ISSN:1936-0851. (American Chemical Society)By high-resoln. scanning tunneling microscopy (STM), the authors revealed unprecedented details about the intermediate steps for a surface-catalyzed reaction. Specifically, the authors studied the oxidn. of H adatoms by O2 mols. on the rutile TiO2(110) surface. O2 adsorbs and successively reacts with the H adatoms, giving water species. Using time-lapsed STM imaging, the authors have unraveled the individual reaction intermediates of HO2, H2O2, and H3O2 stoichiometry and the final reaction product-pairs of water mols., [H2O]2. Because of their different appearance and mobility, these four species are discernible in the time-lapsed STM images. The interpretation of the STM results is corroborated by d. functional theory calcns. The presented exptl. and theor. results are discussed with respect to previous reports where other reaction mechanisms were put forward.
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4Huang, M.; Ritz, C. S.; Novakovic, B.; Yu, D.; Zhang, Y.; Flack, F.; Savage, D. E.; Evans, P. G.; Knezevic, I.; Liu, F.; Lagally, M. G. Mechano-electronic Superlattices in Silicon Nanoribbons ACS Nano 2009, 3, 721– 727Google ScholarThere is no corresponding record for this reference.
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5Kim, D.-H.; Rogers, J. A. Bend, Buckle and Fold: Mechanical Engineering with Nanomembranes ACS Nano 2009, 3, 498– 501Google ScholarThere is no corresponding record for this reference.
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6Babayan, Y.; McMahon, J. M.; Li, S.; Gray, S. K.; Schatz, G. C.; Odom, T. W. Confining Standing Waves in Optical Corrals ACS Nano 2009, 3, 615– 620Google ScholarThere is no corresponding record for this reference.
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7Nordlander, P. The Ring: A Leitmotif in Plasmonics ACS Nano 2009, 3, 488– 492Google ScholarThere is no corresponding record for this reference.
Cited By
This article is cited by 1 publications.
- Yan Sun, Yong Yao, Chao-Guo Yan, Ying Han and Ming Shen. Selective Decoration of Metal Nanoparticles inside or outside of Organic Microstructures via Self-Assembly of Resorcinarene. ACS Nano 2010, 4 (4) , 2129-2141. https://doi.org/10.1021/nn901412n
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References
ARTICLE SECTIONS
This article references 7 other publications.
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1Schrlau, M. G.; Dun, N. J.; Bau, H. H. Cell Electrophysiology with Carbon Nanopipettes ACS Nano 2009, 3, 563– 5681https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BD1MXhsFegtL4%253D&md5=d236f4007e09c99540eb8d8628848554Cell Electrophysiology with Carbon NanopipettesSchrlau, Michael G.; Dun, Nae J.; Bau, Haim H.ACS Nano (2009), 3 (3), 563-568CODEN: ANCAC3; ISSN:1936-0851. (American Chemical Society)The ability to monitor living cell behavior in real time and with high spatial resoln. is vital for advancing our knowledge of cellular machinery and evaluating cellular response to various drugs. Here, we report the development and utilization of carbon-based nanoelectrodes for cell electrophysiol. We employ carbon nanopipettes (CNPs), novel carbon-based nanoprobes which integrate carbon nanopipes into the tips of pulled glass capillaries, to measure elec. signals in the mouse hippocampal cell line HT-22. Using a std. electrophysiol. amplifier in current-clamp mode, we measured the resting membrane potential of cells and their transient membrane response to extracellular pharmacol. agents. In addn. to their superior injection capabilities reported previously, CNPs are capable of multifunctionality, enabling, for example, concurrent intracellular injection and elec. measurements without damaging cells.
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2Mani, V.; Chikkaveeraiah, B. V.; Patel, V.; Gutkind, J. S.; Rusling, J. F. Ultrasensitive Immunosensor for Cancer Biomarker Proteins Using Gold Nanoparticle Film Electrodes and Multienzyme-Particle Amplification ACS Nano 2009, 3, 585– 5942https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BD1MXhvVChtrY%253D&md5=5f711b00d24a9fa8961572db281a3fffUltrasensitive Immunosensor for Cancer Biomarker Proteins Using Gold Nanoparticle Film Electrodes and Multienzyme-Particle AmplificationMani, Vigneshwaran; Chikkaveeraiah, Bhaskara V.; Patel, Vyomesh; Gutkind, J. Silvio; Rusling, James F.ACS Nano (2009), 3 (3), 585-594CODEN: ANCAC3; ISSN:1936-0851. (American Chemical Society)A densely packed gold nanoparticle platform combined with a multiple-enzyme labeled detection antibody-magnetic bead bioconjugate was used as the basis for an ultrasensitive electrochem. immunosensor to detect cancer biomarkers in serum. Sensitivity was greatly amplified by synthesizing magnetic bioconjugates particles contg. 7500 horseradish peroxidase (HRP) labels along with detection antibodies (Ab2) attached to activated carboxyl groups on 1 μm diam. magnetic beads. These sensors had sensitivity of 31.5 μA mL ng-1 and detection limit (DL) of 0.5 pg mL-1 for prostate specific antigen (PSA) in 10 μL of undiluted serum. This represents an ultralow mass DL of 5 fg PSA, 8-fold better than a previously reported carbon nanotube (CNT) forest immunosensor featuring multiple labels on carbon nanotubes, and near or below the normal serum levels of most cancer biomarkers. Measurements of PSA in cell lysates and human serum of cancer patients gave excellent correlations with std. ELISA assays. These easily fabricated AuNP immunosensors show excellent promise for future fabrication of bioelectronic arrays.
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3Matthiesen, J.; Wendt, S.; Hansen, J. Ø.; Madsen, G. K. H.; Lira, E.; Galliker, P.; Vestergaard, E. K.; Schaub, R.; Lægsgaard, E.; Hammer, B. F.et al. Observation of All the Intermediate Steps of a Chemical Reaction on an Oxide Surface by Scanning Tunneling Microscopy ACS Nano 2009, 3, 517– 5263https://chemport.cas.org/services/resolver?origin=ACS&resolution=options&coi=1%3ACAS%3A528%3ADC%252BD1MXhs1Slurs%253D&md5=8f76458810bcdc5239eb9ec97a438bd1Observation of All the Intermediate Steps of a Chemical Reaction on an Oxide Surface by Scanning Tunneling MicroscopyMatthiesen, Jesper; Wendt, Stefan; Hansen, Jonas O.; Madsen, Georg K. H.; Lira, Estephania; Galliker, Patrick; Vestergaard, Ebbe K.; Schaub, Renald; Laegsgaard, Erik; Hammer, Bjork; Besenbacher, FlemmingACS Nano (2009), 3 (3), 517-526CODEN: ANCAC3; ISSN:1936-0851. (American Chemical Society)By high-resoln. scanning tunneling microscopy (STM), the authors revealed unprecedented details about the intermediate steps for a surface-catalyzed reaction. Specifically, the authors studied the oxidn. of H adatoms by O2 mols. on the rutile TiO2(110) surface. O2 adsorbs and successively reacts with the H adatoms, giving water species. Using time-lapsed STM imaging, the authors have unraveled the individual reaction intermediates of HO2, H2O2, and H3O2 stoichiometry and the final reaction product-pairs of water mols., [H2O]2. Because of their different appearance and mobility, these four species are discernible in the time-lapsed STM images. The interpretation of the STM results is corroborated by d. functional theory calcns. The presented exptl. and theor. results are discussed with respect to previous reports where other reaction mechanisms were put forward.
-
4Huang, M.; Ritz, C. S.; Novakovic, B.; Yu, D.; Zhang, Y.; Flack, F.; Savage, D. E.; Evans, P. G.; Knezevic, I.; Liu, F.; Lagally, M. G. Mechano-electronic Superlattices in Silicon Nanoribbons ACS Nano 2009, 3, 721– 727There is no corresponding record for this reference.
-
5Kim, D.-H.; Rogers, J. A. Bend, Buckle and Fold: Mechanical Engineering with Nanomembranes ACS Nano 2009, 3, 498– 501There is no corresponding record for this reference.
-
6Babayan, Y.; McMahon, J. M.; Li, S.; Gray, S. K.; Schatz, G. C.; Odom, T. W. Confining Standing Waves in Optical Corrals ACS Nano 2009, 3, 615– 620There is no corresponding record for this reference.
-
7Nordlander, P. The Ring: A Leitmotif in Plasmonics ACS Nano 2009, 3, 488– 492There is no corresponding record for this reference.
-