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Hemoglobin Synthesis in Murine Virus-Induced Leukemic Cells In Vitro: Stimulation of Erythroid Differentiation by Dimethyl Sulfoxide

February 1, 1971
68 (2) 378-382

Abstract

Cells of a cloned line of murine virus-induced erythroleukemia were stimulated to differentiate along the erythroid pathway by dimethyl sulfoxide at concentrations that did not inhibit growth. A rise in the number of benzidine-positive normoblasts was accompanied by increased synthesis of heme and hemoglobin and a decrease in the malignancy of the cells. This action of dimethyl sulfoxide, which was reversible, may represent the derepression of leukemic cells to permit their maturation.

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Published in

Go to Proceedings of the National Academy of Sciences
Go to Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences
Vol. 68 | No. 2
February 1971
PubMed: 5277089

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Published online: February 1, 1971
Published in issue: February 1971

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Center for Experimental Cell Biology, Mollie B. Roth Laboratory, The Mount Sinai School of Medicine of the City University of New York, New York, N.Y. 10029
Division of Cytology, the Sloan-Kettering Institute for Cancer Research, New York, N.Y. 10021

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    Hemoglobin Synthesis in Murine Virus-Induced Leukemic Cells In Vitro: Stimulation of Erythroid Differentiation by Dimethyl Sulfoxide
    Proceedings of the National Academy of Sciences
    • Vol. 68
    • No. 2

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