Crosstalk Between Calcium and Redox Signaling: From Molecular Mechanisms to Health Implications
Publication: Antioxidants & Redox Signaling
Volume 10, Issue Number 7
Abstract
Studies done many years ago established unequivocally the key role of calcium as a universal second messenger. In contrast, the second messenger roles of reactive oxygen and nitrogen species have emerged only recently. Therefore, their contributions to physiological cell signaling pathways have not yet become universally accepted, and many biological researchers still regard them only as cellular noxious agents. Furthermore, it is becoming increasingly apparent that there are significant interactions between calcium and redox species, and that these interactions modify a variety of proteins that participate in signaling transduction pathways and in other fundamental cellular functions that determine cell life or death. This review article addresses first the central aspects of calcium and redox signaling pathways in animal cells, and continues with the molecular mechanisms that underlie crosstalk between calcium and redox signals under a number of physiological or pathological conditions. To conclude, the review focuses on conditions that, by promoting cellular oxidative stress, lead to the generation of abnormal calcium signals, and how this calcium imbalance may cause a variety of human diseases including, in particular, degenerative diseases of the central nervous system and cardiac pathologies.
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Published In
Antioxidants & Redox Signaling
Volume 10 • Issue Number 7 • July 2008
Pages: 1275 - 1312
PubMed: 18377233
Copyright
Mary Ann Liebert, Inc.
History
Published in print: July 2008
Published online: 30 April 2008
Published ahead of print: 31 March 2008
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