Clinical Implant Dentistry and Related Research

Volume 16, Issue 2 p. 194-201

ARTICLE

Vertical Osteoconductive Characteristics of Titanium Implants with Calcium-Phosphate-Coated Surfaces – A Pilot Study in Rabbits

Eik Schiegnitz MD,

Corresponding Author

Eik Schiegnitz MD

Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany;

Dr. Eik Schiegnitz, Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Centre of the Johannes Gutenberg-University. Augustusplatz 2, 55131 Mainz, Germany; e-mail: [email protected]Search for more papers by this author

Victor Palarie DDS,

Victor Palarie DDS

State Medical and Pharmaceutical University “Nicolae Testemitanu”, Chisinau, Moldova, Clinic for Oral & Maxillofacial Surgery, Chisinau, Moldova;

Search for more papers by this author

Viorel Nacu MD, PhD,

Viorel Nacu MD, PhD

State Medical and Pharmaceutical University “Nicolae Testemitanu,” Chisinau, Moldova, Clinic for Oral & Maxillofacial Surgery, Chisinau, Moldova;

Search for more papers by this author

Bilal Al-Nawas MD, DMD, PhD,

Bilal Al-Nawas MD, DMD, PhD

Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany;

Search for more papers by this author

Peer Wolfgang Kämmerer MD, DMD,

Peer Wolfgang Kämmerer MD, DMD

Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany

Search for more papers by this author

Eik Schiegnitz MD,

Corresponding Author

Eik Schiegnitz MD

Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany;

Victor Palarie DDS,

Victor Palarie DDS

State Medical and Pharmaceutical University “Nicolae Testemitanu”, Chisinau, Moldova, Clinic for Oral & Maxillofacial Surgery, Chisinau, Moldova;

Search for more papers by this author

Viorel Nacu MD, PhD,

Viorel Nacu MD, PhD

State Medical and Pharmaceutical University “Nicolae Testemitanu,” Chisinau, Moldova, Clinic for Oral & Maxillofacial Surgery, Chisinau, Moldova;

Search for more papers by this author

Bilal Al-Nawas MD, DMD, PhD,

Bilal Al-Nawas MD, DMD, PhD

Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany;

Search for more papers by this author

Peer Wolfgang Kämmerer MD, DMD,

Peer Wolfgang Kämmerer MD, DMD

Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany

Search for more papers by this author

First published: 25 April 2014

https://doi.org/10.1111/j.1708-8208.2012.00469.x

Citations: 15

The authors Schiegnitz and Palarie contributed equally in this study.

There are no commercial or other associations that might create a duality of interests in connection with the article.

Read the full text

About

PDF

Tools

Share a link

Email
Facebook
Twitter
LinkedIn
Reddit
Wechat

ABSTRACT

Introduction: Osteoconductive characteristics of different implant surface coatings are in the focus of current interest. The aim of the present study was to compare the vertical osteoconductivity at the implant shoulder of supracrestal inserted calcium-phosphate coated implants (SLA-CaP) with conventional sand-blasted/acid-etched (SLA) implants in a rabbit model.

Materials and Methods: SLA-CaP and SLA implants were inserted bilaterally in the mandible of four rabbits in a split-mouth design. The implants were placed 2 mm supracrestal. After 3 weeks, at the left and right implant shoulder, the percentage of linear bone fill (PLF) as well as bone-implant contact (BIC-D) were determined.

Results: After 3 weeks, newly formed woven bone could be found at the shoulder of the most of both surface-treated implants (75%). PLF was significantly higher in SLA-CaP implants (11.2% vs. 46.5%; n = 8, p = .008). BIC-D was significantly increased in the SLA-CaP implants (13.0% vs. 71.4%; n = 8, p < .001) as well.

Conclusion: The results of this study show for the first time that calcium-phosphate coated surfaces on supracrestal inserted implants have vertical osteoconductive characteristics and increase the bone-implant contact at the implant shoulder significantly in a rabbit model. In clinical long-term settings, these implants may contribute to a better vertical bone height.

REFERENCES

1 Jemt T , Chai J , Harnett J , et al . A 5-year prospective multicenter follow-up report on overdentures supported by osseointegrated implants . Int J Oral Maxillofac Implants 1996 ; 11 : 291 – 298 .

CASPubMedGoogle Scholar
2 Lindquist LW , Carlsson GE , Jemt T . A prospective 15-year follow-up study of mandibular fixed prostheses supported by osseointegrated implants. Clinical results and marginal bone loss . Clin Oral Implants Res 1996 ; 7 : 329 – 336 .
10.1034/j.1600-0501.1996.070405.x
CASPubMedWeb of Science®Google Scholar
3 Lambrecht JT , Filippi A , Kunzel AR , Schiel HJ . Long-term evaluation of submerged and nonsubmerged ITI solid-screw titanium implants: a 10-year life table analysis of 468 implants . Int J Oral Maxillofac Implants 2003 ; 18 : 826 – 834 .

PubMedWeb of Science®Google Scholar
4 Kumar V , Sagheb K , Klein MO , Al-Nawas B , Kann PH , Kämmerer PW . Relation between bone quality values from ultrasound transmission velocity and implant stability parameters – an ex-vivo study . Clin Oral Imp Res 2011 . DOI: 10.1111/j.1600-0501.2011.02250.x. [Epub ahead of print] .

Google Scholar
5 Herrmann I , Lekholm U , Holm S , Kultje C . Evaluation of patient and implant characteristics as potential prognostic factors for oral implant failures . Int J Oral Maxillofac Implants 2005 ; 20 : 220 – 230 .

PubMedWeb of Science®Google Scholar
6 Puleo DA , Nanci A . Understanding and controlling the bone-implant interface . Biomaterials 1999 ; 20 : 2311 – 2321 .
10.1016/S0142-9612(99)00160-X
CASPubMedWeb of Science®Google Scholar
7 Al-Nawas B , Wagner W , Grotz KA . Insertion torque and resonance frequency analysis of dental implant systems in an animal model with loaded implants . Int J Oral Maxillofac Implants 2006 ; 21 : 726 – 732 .

PubMedWeb of Science®Google Scholar
8 Klein MO , Bijelic A , Ziebart T , et al . Submicron scale-structured hydrophilic titanium surfaces promote early osteogenic gene response for cell adhesion and cell differentiation . Clin Implant Dent Relat Res 2011 . DOI: 10.1111/j.1708-8208.2011.00339.x. [Epub ahead of print] .

Google Scholar
9 Kämmerer PW , Heller M , Brieger J , Klein MO , Al-Nawas B , Gabriel M . Immobilization of linear and cyclic RGD-peptides on titanium surfaces and their impact on endothelial cell adhesion and proliferation . Eur Cell Mater 2011 ; 11 : 364 – 372 .
10.22203/eCM.v021a27
Google Scholar
10 Lai HC , Zhuang LF , Zhang ZY , Wieland M , Liu X . Bone apposition around two different sandblasted, large-grit and acid-etched implant surfaces at sites with coronal circumferential defects: an experimental study in dogs . Clin Oral Implants Res 2009 ; 20 : 247 – 253 .
10.1111/j.1600-0501.2008.01651.x
CASPubMedWeb of Science®Google Scholar
11 Vignoletti F , de Sanctis M , Berglundh T , Abrahamsson I , Sanz M . Early healing of implants placed into fresh extraction sockets: an experimental study in the beagle dog. III: soft tissue findings . J Clin Periodontol 2009 ; 36 : 1059 – 1066 .
10.1111/j.1600-051X.2009.01489.x
CASPubMedWeb of Science®Google Scholar
12 Schwarz F , Herten M , Sager M , Wieland M , Dard M , Becker J . Bone regeneration in dehiscence-type defects at chemically modified (SLActive) and conventional SLA titanium implants: a pilot study in dogs . J Clin Periodontol 2007 ; 34 : 78 – 86 .
10.1111/j.1600-051X.2006.01008.x
CASPubMedWeb of Science®Google Scholar
13 Schwarz F , Rothamel D , Herten M , et al . Immunohistochemical characterization of guided bone regeneration at a dehiscence-type defect using different barrier membranes: an experimental study in dogs . Clin Oral Implants Res 2008 ; 19 : 402 – 415 .
10.1111/j.1600-0501.2007.01486.x
CASPubMedWeb of Science®Google Scholar
14 Wikesjo UM , Qahash M , Polimeni G , et al . Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-2: histologic observations . J Clin Periodontol 2008 ; 35 : 1001 – 1010 .
10.1111/j.1600-051X.2008.01321.x
CASPubMedWeb of Science®Google Scholar
15 Strnad Z , Strnad J , Povysil C , Urban K . Effect of plasma-sprayed hydroxyapatite coating on the osteoconductivity of commercially pure titanium implants . Int J Oral Maxillofac Implants 2000 ; 15 : 483 – 490 .

CASPubMedWeb of Science®Google Scholar
16 Weinlaender M . Bone growth around dental implants . Dent Clin North Am 1991 ; 35 : 585 – 601 .

CASPubMedGoogle Scholar
17 Palarie V , Bicer C , Lehmann KM , Zahalka M , Draenert FG , Kammerer PW . Early outcome of an implant system with a resorbable adhesive calcium-phosphate coating – a prospective clinical study in partially dentate patients . Clin Oral Investig 2010 . DOI: 10.1007/s00784-011-0598-8. [Epub ahead of print] .

Google Scholar
18 Donath K , Breuner G . A method for the study of undecalcified bones and teeth with attached soft tissues. The Sage-Schliff (sawing and grinding) technique . J Oral Pathol 1982 ; 11 : 318 – 326 .
10.1111/j.1600-0714.1982.tb00172.x
CASPubMedWeb of Science®Google Scholar
19 Wagner W , Tetsch P , Ackermann KL , Bohmer U , Dahl H . Animal experimental studies on bone regeneration in standardized defects after the implantation of tricalcium phosphate ceramic . Dtsch Zahnarztl Z 1981 ; 36 : 82 – 85 .

CASPubMedGoogle Scholar
20 Bose S , Tarafder S . Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: a review . Acta Biomater 2012 ; 8 : 1401 – 1421 .
10.1016/j.actbio.2011.11.017
CASPubMedWeb of Science®Google Scholar
21 Sennerby L , Dasmah A , Larsson B , Iverhed M . Bone tissue responses to surface-modified zirconia implants: a histomorphometric and removal torque study in the rabbit . Clin Implant Dent Relat Res 2005 ; 7 ( Suppl 1 ): S13 – S20 .
10.1111/j.1708-8208.2005.tb00070.x
PubMedWeb of Science®Google Scholar
22 Susin C , Qahash M , Hall J , Sennerby L , Wikesjo UM . Histological and biomechanical evaluation of phosphorylcholine-coated titanium implants . J Clin Periodontol 2008 ; 35 : 270 – 275 .
10.1111/j.1600-051X.2007.01196.x
CASPubMedWeb of Science®Google Scholar
23 Draenert FG , Kammerer PW , Palarie V , Wagner W . Vertical bone augmentation with simultaneous dental implantation using crestal biomaterial rings: a rabbit animal study . Clin Implant Dent Relat Res 2012 ; 14 ( Suppl s1 ): e169 – e174 .
10.1111/j.1708-8208.2011.00401.x
PubMedWeb of Science®Google Scholar
24 Freilich M , Shafer D , Wei M , Kompalli R , Adams D , Kuhn L . Implant system for guiding a new layer of bone. Computed microtomography and histomorphometric analysis in the rabbit mandible . Clin Oral Implants Res 2009 ; 20 : 201 – 207 .
10.1111/j.1600-0501.2008.01615.x
CASPubMedWeb of Science®Google Scholar
25 Meirelles L , Uzumaki ET , Lima JH , et al . A novel technique for tailored surface modification of dental implants – a step wise approach based on plasma immersion ion implantation . Clin Oral Implants Res 2011 . DOI: 10.1111/j.1600-0501.2011.02352.x. [Epub ahead of print] .

PubMedWeb of Science®Google Scholar
26 Schlegel KA , Prechtl C , Most T , Seidl C , Lutz R , von Wilmowsky C . Osseointegration of SLActive implants in diabetic pigs . Clin Oral Implants Res 2011 . DOI: 10.1111/j.1600-0501.2011.02380.x. [Epub ahead of print] .

Google Scholar
27 de Barros RR , Novaes AB Jr , Queiroz A , de Almeida AL . Early peri-implant endosseous healing of two implant surfaces placed in surgically created circumferential defects. A histomorphometric and fluorescence study in dogs . Clin Oral Implants Res 2011 . DOI: 10.1111/j.1600-0501.2011.02357.x. [Epub ahead of print] .

PubMedWeb of Science®Google Scholar
28 Zeggel P . Bioactive calcium phosphate coatings for dental implants . Int Mag Oral Implant 2000 ; 1 : 52 – 57 .

Google Scholar
29 Caulier H , van der Waerden JP , Wolke JG , Kalk W , Naert I , Jansen JA . A histological and histomorphometrical evaluation of the application of screw-designed calciumphosphate (Ca-P)-coated implants in the cancellous maxillary bone of the goat . J Biomed Mater Res 1997 ; 35 : 19 – 30 .
10.1002/(SICI)1097-4636(199704)35:1<19::AID-JBM3>3.0.CO;2-P
CASPubMedWeb of Science®Google Scholar
30 Karabuda C , Sandalli P , Yalcin S , Steflik DE , Parr GR . Histologic and histomorphometric comparison of immediately placed hydroxyapatite-coated and titanium plasma-sprayed implants: a pilot study in dogs . Int J Oral Maxillofac Implants 1999 ; 14 : 510 – 515 .

CASPubMedWeb of Science®Google Scholar
31 Mohammadi S , Esposito M , Hall J , Emanuelsson L , Krozer A , Thomsen P . Short-term bone response to titanium implants coated with thin radiofrequent magnetron-sputtered hydroxyapatite in rabbits . Clin Implant Dent Relat Res 2003 ; 5 : 241 – 253 .
10.1111/j.1708-8208.2003.tb00207.x
CASPubMedGoogle Scholar
32 Webster TJ , Ergun C , Doremus RH , Lanford WA . Increased osteoblast adhesion on titanium-coated hydroxylapatite that forms CaTiO3 . J Biomed Mater Res A 2003 ; 67 : 975 – 980 .
10.1002/jbm.a.10160
CASPubMedWeb of Science®Google Scholar
33 Suh JY , Jeung OC , Choi BJ , Park JW . Effects of a novel calcium titanate coating on the osseointegration of blasted endosseous implants in rabbit tibiae . Clin Oral Implants Res 2007 ; 18 : 362 – 369 .
10.1111/j.1600-0501.2006.01323.x
CASPubMedWeb of Science®Google Scholar
34 Jansen JA , van der Waerden JP , Wolke JG . Histologic investigation of the biologic behavior of different hydroxyapatite plasma-sprayed coatings in rabbits . J Biomed Mater Res 1993 ; 27 : 603 – 610 .
10.1002/jbm.820270507
CASPubMedWeb of Science®Google Scholar
35 Fontana F , Rocchietta I , Addis A , Schupbach P , Zanotti G , Simion M . Effects of a calcium phosphate coating on the osseointegration of endosseous implants in a rabbit model . Clin Oral Implants Res 2010 ; 22 : 760 – 766 .
10.1111/j.1600-0501.2010.02056.x
PubMedWeb of Science®Google Scholar
36 Ducheyne P , Beight J , Cuckler J , Evans B , Radin S . Effect of calcium phosphate coating characteristics on early post-operative bone tissue ingrowth . Biomaterials 1990 ; 11 : 531 – 540 .
10.1016/0142-9612(90)90073-Y
CASPubMedWeb of Science®Google Scholar
37 Palarie V , Bicer C , Lehmann KM , Zahalka M , Draenert FG , Kammerer PW . Early outcome of an implant system with a resorbable adhesive calcium-phosphate coating – a prospective clinical study in partially dentate patients . Clin Oral Investig 2011 . DOI: 10.1007/s00784-011-0598-8. [Epub ahead of print] .

PubMedWeb of Science®Google Scholar
38 Daculsi G , Laboux O , Malard O , Weiss P . Current state of the art of biphasic calcium phosphate bioceramics . J Mater Sci Mater Med 2003 ; 14 : 195 – 200 .
10.1023/A:1022842404495
CASPubMedWeb of Science®Google Scholar
39 Davies JE . Understanding peri-implant endosseous healing . J Dent Educ 2003 ; 67 : 932 – 949 .
10.1002/j.0022-0337.2003.67.8.tb03681.x
PubMedGoogle Scholar
40 Barrere F , van der Valk CM , Meijer G , Dalmeijer RA , de Groot K , Layrolle P . Osteointegration of biomimetic apatite coating applied onto dense and porous metal implants in femurs of goats . J Biomed Mater Res B Appl Biomater 2003 ; 67 : 655 – 665 .
10.1002/jbm.b.10057
PubMedWeb of Science®Google Scholar
41 Geurs NC , Jeffcoat RL , McGlumphy EA , Reddy MS , Jeffcoat MK . Influence of implant geometry and surface characteristics on progressive osseointegration . Int J Oral Maxillofac Implants 2002 ; 17 : 811 – 815 .

PubMedWeb of Science®Google Scholar

Citing Literature

Volume16, Issue2

April 2014

Pages 194-201

Vertical Osteoconductive Characteristics of Titanium Implants with Calcium-Phosphate-Coated Surfaces – A Pilot Study in Rabbits

ABSTRACT

REFERENCES

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley