Genetic Mapping in Human Disease
Abstract
Genetic mapping provides a powerful approach to identify genes and biological processes underlying any trait influenced by inheritance, including human diseases. We discuss the intellectual foundations of genetic mapping of Mendelian and complex traits in humans, examine lessons emerging from linkage analysis of Mendelian diseases and genome-wide association studies of common diseases, and discuss questions and challenges that lie ahead.
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Published In
Science
Volume 322 | Issue 5903
7 November 2008
7 November 2008
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American Association for the Advancement of Science.
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Published in print: 7 November 2008
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