Experimental Evolution of Parasites
Abstract
Serial passage experiments are a form of experimental evolution that is frequently used in applied sciences; for example, in vaccine development. During these experiments, molecular and phenotypic evolution can be monitored in real time, providing insights into the causes and consequences of parasite evolution. Within-host competition generally drives an increase in a parasite's virulence in a new host, whereas the parasite becomes avirulent to its former host, indicating a trade-off between parasite fitnesses on different hosts. Understanding why parasite virulence seldom escalates similarly in natural populations could help us to manage virulence and deal with emerging diseases.
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I thank A. Carius, J. Hottinger, T. Kawecki, R. Lenski, T. Little, P. Schmid-Hempel, S.C. Stearns, and N. Sokolova for help and encouragment during various steps in the preparation of this paper. I am supported by the Swiss Nationalfond (grant no. 3100-043093.95).
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Science
Volume 282 | Issue 5393
20 November 1998
20 November 1998
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Published in print: 20 November 1998
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