Helicobacter pylori Virulence and Genetic Geography
Abstract
Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is responsible for gastritis, peptic ulcer, and gastric cancer. A pathogenicity island acquired by horizontal transfer, coding for a type IV secretion system, is a major determinant of virulence. The infection is now treated with antibiotics, and vaccines are in preparation. The geographic distribution suggests coevolution of man and Helicobacter pylori.
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This article is dedicated to Stanley Falkow. The work of L. L. Cavalli-Sforza was a major source of inspiration. We acknowledge S. Lory for the analysis of Pseudomonas genome; P. Christie and J. Hacker for suggestions; and N. Lange, S. Guidotti, J. M. Reyrat, X. Ji, M. Stein, and E. Segal for granting access to experimental data. We gratefully acknowledge G. Corsi for the illustrations and C. Mallia for editorial assistance.
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Volume 284 | Issue 5418
21 May 1999
21 May 1999
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Published in print: 21 May 1999
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- Antonello Covacci et al.
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