Isolation of T-Cell Tropic HTLV-III-Like Retrovirus from Macaques
Abstract
The isolation of a T-cell tropic retrovirus from three immunodeficient macaques and one macaque with lymphoma is described. The morphology, growth characteristics, and antigenic properties of this virus indicate that it is related to the causative agent of acquired immune deficiency syndrome in humans (HTLV-III or LAV). This virus is referred to as simian T-lymphotropic virus type III (STLV-III) of macaques. The existence of a cytopathic, T-cell tropic virus resembling HTLV-III in monkeys may facilitate study of disease induction and vaccine development in an animal model.
Get full access to this article
View all available purchase options and get full access to this article.
References
MORBIDITY AND MORTALITY WEEKLY REPORT 33: 661 (1984).
ALTER, H.J., TRANSMISSION OF HTLV-III INFECTION FROM HUMAN-PLASMA TO CHIMPANZEES - AN ANIMAL-MODEL FOR AIDS, SCIENCE 226: 549 (1984).
BRUNVEZINET, SCIENCE 226: 453 (1984).
CHALIFOUX, L.V., MORPHOLOGIC CHANGES IN LYMPH-NODES OF MACAQUES WITH AN IMMUNODEFICIENCY SYNDROME, LABORATORY INVESTIGATION 51: 22 (1984).
DALGLEISH, A.G., THE CD4 (T4) ANTIGEN IS AN ESSENTIAL COMPONENT OF THE RECEPTOR FOR THE AIDS RETROVIRUS, NATURE 312: 763 (1984).
DANIEL, M.D., A NEW TYPE-D RETROVIRUS ISOLATED FROM MACAQUES WITH AN IMMUNODEFICIENCY SYNDROME, SCIENCE 223: 602 (1984).
DESROSIERS, R.C., RETROVIRUS-D/NEW-ENGLAND AND ITS RELATION TO MASON-PFIZER MONKEY VIRUS, JOURNAL OF VIROLOGY 54: 552 (1985).
GAJDUSEK, D.C., TRANSMISSION EXPERIMENTS WITH HUMAN T-LYMPHOTROPIC RETROVIRUSES AND HUMAN AIDS TISSUE, LANCET 1: 1415 (1984).
GAJDUSEK, D.C., INFECTION OF CHIMPANZEES BY HUMAN T-LYMPHOTROPIC RETROVIRUSES IN BRAIN AND OTHER TISSUES FROM AIDS PATIENTS, LANCET 1: 55 (1985).
GAJDUSEK, D, MORBIDITY AND MORTALITY WEEKLY REPORT 33: 442 (1984).
GALLO, R.C., FREQUENT DETECTION AND ISOLATION OF CYTOPATHIC RETROVIRUSES (HTLV-III) FROM PATIENTS WITH AIDS AND AT RISK FOR AIDS, SCIENCE 224: 500 (1984).
GAZDAR, A.F., MITOGEN REQUIREMENTS FOR THE INVITRO-PROPAGATION OF CUTANEOUS T-CELL LYMPHOMAS, BLOOD 55: 409 (1980).
GOOTENBERG, J.E., HUMAN CUTANEOUS T-CELL LYMPHOMA AND LEUKEMIA-CELL LINES PRODUCE AND RESPOND TO T-CELL GROWTH-FACTOR, JOURNAL OF EXPERIMENTAL MEDICINE 154: 1403 (1981).
HAYAMI, M, PREVALENCE OF ANTIBODY TO ADULT T-CELL LEUKEMIA VIRUS-ASSOCIATED ANTIGENS (ATLA) IN JAPANESE MONKEYS AND OTHER NON-HUMAN PRIMATES, INTERNATIONAL JOURNAL OF CANCER 33: 179 (1984).
HAYAMI, M, ATLV ANTIBODY IN CYNOMOLGUS MONKEYS IN THE WILD, LANCET 2: 620 (1983).
HENRICKSON, R.V., CLINICAL-FEATURES OF SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME (SAIDS) IN RHESUS-MONKEYS, LABORATORY ANIMAL SCIENCE 34: 140 (1984).
HENRICKSON, R.V., EPIDEMIC OF ACQUIRED IMMUNODEFICIENCY IN RHESUS-MONKEYS, LANCET 1: 388 (1983).
HOMMA, T, LYMPHOMA IN MACAQUES - ASSOCIATION WITH VIRUS OF HUMAN T-LYMPHOTROPHIC FAMILY, SCIENCE 225: 716 (1984).
HUNSMANN, G, DETECTION OF SERUM ANTIBODIES TO ADULT T-CELL LEUKEMIA-VIRUS IN NON-HUMAN PRIMATES AND IN PEOPLE FROM AFRICA, INTERNATIONAL JOURNAL OF CANCER 32: 329 (1983).
HUNT, R.D., TRANSMISSION OF NATURALLY-OCCURRING LYMPHOMA IN MACAQUE MONKEYS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 80: 5085 (1983).
ISHIDA, T, SEROEPIDEMIOLOGICAL STUDY OF ANTIBODIES TO ADULT T-CELL LEUKEMIA VIRUS-ASSOCIATED ANTIGEN (ATLA) IN FREE-RANGING JAPANESE MONKEYS (MACACA-FUSCATA), MICROBIOLOGY AND IMMUNOLOGY 27: 297 (1983).
KANKI, P.J., SEROLOGIC IDENTIFICATION AND CHARACTERIZATION OF A MACAQUE T-LYMPHOTROPIC RETROVIRUS CLOSELY RELATED TO HTLV-III, SCIENCE 228: 1199 (1985).
KING, N.W., HISTOPATHOLOGIC CHANGES IN MACAQUES WITH AN ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), AMERICAN JOURNAL OF PATHOLOGY 113: 382 (1983).
KLATZMANN, D, SELECTIVE TROPISM OF LYMPHADENOPATHY ASSOCIATED VIRUS (LAV) FOR HELPER-INDUCER LYMPHOCYTES-T, SCIENCE 225: 59 (1984).
KOMURO, A, DETECTION AND CHARACTERIZATION OF SIMIAN RETROVIRUSES HOMOLOGOUS TO HUMAN T-CELL LEUKEMIA-VIRUS TYPE-1, VIROLOGY 138: 373 (1984).
LETVIN, N.L., EXPERIMENTAL-INFECTION OF RHESUS-MONKEYS WITH TYPE-D RETROVIRUS, JOURNAL OF VIROLOGY 52: 683 (1984).
LETVIN, N.L., EXPERIMENTAL TRANSMISSION OF MACAQUE AIDS BY MEANS OF INOCULATION OF MACAQUE LYMPHOMA TISSUE, LANCET 2: 599 (1983).
LETVIN, N.L., ACQUIRED IMMUNODEFICIENCY SYNDROME IN A COLONY OF MACAQUE MONKEYS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 80: 2718 (1983).
MARX, P.A., SIMIAN AIDS - ISOLATION OF A TYPE-D RETROVIRUS AND TRANSMISSION OF THE DISEASE, SCIENCE 223: 1083 (1984).
MIYOSHI, I, NATURAL INFECTION IN NON-HUMAN PRIMATES WITH ADULT T-CELL LEUKEMIA-VIRUS OR A CLOSELY RELATED AGENT, INTERNATIONAL JOURNAL OF CANCER 32: 333 (1983).
MIYOSHI, I, NATURAL ADULT T-CELL LEUKEMIA-VIRUS INFECTION IN JAPANESE MONKEYS, LANCET 2: 658 (1982).
MIYOSHI, I, LANCET 1: 166 (1983).
POPOVIC, M, T4 POSITIVE HUMAN NEOPLASTIC CELL-LINES SUSCEPTIBLE TO AND PERMISSIVE FOR HTLV-III, LANCET 2: 1472 (1984).
POPOVIC, M, DETECTION, ISOLATION, AND CONTINUOUS PRODUCTION OF CYTOPATHIC RETROVIRUSES (HTLV-III) FROM PATIENTS WITH AIDS AND PRE-AIDS, SCIENCE 224: 497 (1984).
SAFAI, B, SEROEPIDEMIOLOGICAL STUDIES OF HUMAN LYMPHOTROPIC-T RETROVIRUS TYPE-III IN ACQUIRED IMMUNODEFICIENCY SYNDROME, LANCET 1: 1438 (1984).
SARNGADHARAN, M.G., ANTIBODIES REACTIVE WITH HUMAN T-LYMPHOTROPIC RETROVIRUSES (HTLV-III) IN THE SERUM OF PATIENTS WITH AIDS, SCIENCE 224: 506 (1984).
SCHUPBACH, J, SEROLOGICAL ANALYSIS OF A SUBGROUP OF HUMAN T-LYMPHOTROPIC RETROVIRUSES (HTLV-III) ASSOCIATED WITH AIDS, SCIENCE 224: 503 (1984).
SHAW, G.M., HTLV-III INFECTION IN BRAINS OF CHILDREN AND ADULTS WITH AIDS ENCEPHALOPATHY, SCIENCE 227: 177 (1985).
STROMBERG, K, CHARACTERIZATION OF EXOGENOUS TYPE-D RETROVIRUS FROM A FIBROMA OF A MACAQUE WITH SIMIAN AIDS AND FIBROMATOSIS, SCIENCE 224: 289 (1984).
YAMAMOTO, M, DISTRIBUTION OF COLLAGEN TYPE-I, TYPE-III, AND TYPE-V IN FIBROTIC AND NEOPLASTIC HUMAN-LIVER, ACTA PATHOLOGICA JAPONICA 34: 77 (1984).
YAMAMOTO, N, HUMAN ADULT T-CELL LEUKEMIA-VIRUS IS DISTINCT FROM A SIMILAR ISOLATE OF JAPANESE MONKEYS, JOURNAL OF GENERAL VIROLOGY 65: 2259 (1984).
YAMAMOTO, N, AFRICAN-GREEN MONKEYS ARE INFECTED WITH ADULT T-CELL LEUKEMIA-VIRUS OR A CLOSELY RELATED AGENT, LANCET 1: 240 (1983).
(0)eLetters
eLetters is a forum for ongoing peer review. eLetters are not edited, proofread, or indexed, but they are screened. eLetters should provide substantive and scholarly commentary on the article. Embedded figures cannot be submitted, and we discourage the use of figures within eLetters in general. If a figure is essential, please include a link to the figure within the text of the eLetter. Please read our Terms of Service before submitting an eLetter.
Log In to Submit a ResponseNo eLetters have been published for this article yet.
Information & Authors
Information
Published In
Science
Volume 228 | Issue 4704
7 June 1985
7 June 1985
Copyright
© 1985.
Submission history
Published in print: 7 June 1985
Authors
Metrics & Citations
Metrics
Article Usage
Altmetrics
Citations
Cite as
- M. D. Daniel et al.
Export citation
Select the format you want to export the citation of this publication.
Cited by
- AIDS as a Zoonosis: Scientific and Public Health Implications, Science, 287, 5453, (607-614), (2000)./doi/10.1126/science.287.5453.607
- Pathogenicity of Live, Attenuated SIV After Mucosal Infection of Neonatal Macaques, Science, 267, 5205, (1820-1825), (1995)./doi/10.1126/science.7892606
- Protective Effects of a Live Attenuated SIV Vaccine with a Deletion in the nef Gene, Science, 258, 5090, (1938-1941), (1992)./doi/10.1126/science.1470917
- Induction of Mucosal and Systemic Immunity to a Recombinant Simian Immunodeficiency Viral Protein, Science, 258, 5086, (1365-1369), (1992)./doi/10.1126/science.1360702
- Enhancement of SIV Infection with Soluble Receptor Molecules, Science, 247, 4946, (1084-1088), (1990)./doi/10.1126/science.2309120
- Expanded HIV-1 Cellular Tropism by Phenotypic Mixing with Murine Endogenous Retroviruses, Science, 247, 4944, (848-852), (1990)./doi/10.1126/science.2305256
- Induction of AIDS in Rhesus Monkeys by Molecularly Cloned Simian Immunodeficiency Virus, Science, 248, 4959, (1109-1112), (1990)./doi/10.1126/science.2160735
- A Quantitative Bioassay for HIV-1 Based on Trans-Activation, Science, 239, 4836, (184-187), (1988)./doi/10.1126/science.3422113
- Isolation and Characterization of a Novel Protein (X-ORF Product) from SIV and HIV-2, Science, 241, 4862, (199-201), (1988)./doi/10.1126/science.3388031
- The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis, Science, 239, 4840, (617-622), (1988)./doi/10.1126/science.3277274
- See more
Loading...
View Options
Check Access
Log in to view the full text
AAAS login provides access to Science for AAAS Members, and access to other journals in the Science family to users who have purchased individual subscriptions.
- Become a AAAS Member
- Activate your AAAS ID
- Purchase Access to Other Journals in the Science Family
- Account Help
Log in via OpenAthens.
Log in via Shibboleth.
More options
Purchase digital access to this article
Download and print this article for your personal scholarly, research, and educational use.
Buy a single issue of Science for just $15 USD.
View options
PDF format
Download this article as a PDF file
Download PDF