rRNA Binding Sites and the Molecular Mechanism of Action of the Tetracyclines
ABSTRACT
INTRODUCTION
OVERVIEW OF INTERACTIONS OF rRNA WITH ANTIBIOTICS
COMPOSITION, STRUCTURE, AND FUNCTION OF rRNA
DOUBLE-STRANDED RNAs IN CELLS
STRUCTURE AND ANTIMICROBIAL ACTIVITY SPECTRUM OF THE TETRACYCLINES
Infection type (examples) or disease condition | Drug(s) used | Target(s)a | Mechanism(s) of actiona | Reference(s) |
---|---|---|---|---|
Bacterial infectionb (anthrax, bubonic plague, Rocky Mountain spotted fever [Rickettsia rickettsii], borreliosis, psittacosis [Chlamydia psittaci], leptospirosis [spirochetes]) | All tetracyclines | 16S rRNA | Inhibits protein synthesis by inhibiting binding of aminoacyl-tRNA to mRNA-ribosome complex | 8, 39 |
Viral infections (West Nile virus, HIV, Japanese encephalitis virus) | Minocycline | CD4+ T cells | Suppresses activation of CD4+ T cells; anti-inflammatory, antiapoptotic, and neuroprotective | 2, 13, 14, 68–70 |
Protozoan infections (malaria, toxoplasmosis, leishmaniasis, amoebic dysentery, giardiasis, trichomoniasis) | Doxycycline, minocycline | Mitochondria and apicoplasts | Inhibits mitochondrial protein synthesisc | 5–7, 67, 86 |
Helminth infections (lymphatic filariasis, onchocerciasis) | Doxycycline | Wolbachia endosymbionts | Eliminates bacterial endosymbiont(s) necessary for parasite survival and reproduction | 40 |
Acne and rosacea | All tetracyclines | Anti-inflammatory | 15 | |
Elephantiasis | Doxycycline | Reduces plasma VEGF; anti-inflammatory | 4 | |
Osteoarthritis | Doxycycline, minocycline | Nitric oxide synthase | Inhibits RNA expression, translation of enzyme | 71 |
ROLE OF METAL IONS IN THE PHARMACOKINETICS OF TETRACYCLINES
MECHANISM(S) OF ACTION OF THE TETRACYCLINES: THE JOURNEY SO FAR
Mechanism of antibacterial activity based on interactions of tetracycline antibiotics with bacterial rRNA.
Current theories on the mechanism(s) of action against nonbacterial pathogens and noninfectious disease conditions.
Consideration of tetracyclines as dsRNA ligands for a potential mechanism of action for their wide range of activities.
Proposed mechanism of selective microbial protein synthesis inhibition by the tetracyclines.
(i) Higher-affinity binding for prokaryotic rRNAs versus eukaryotic rRNAs.
(ii) Relative effects of drug binding on processing of prokaryotic versus eukaryotic RNAs.
CONCLUSION
REFERENCES
Author Bios
Information & Contributors
Information
Published In
Copyright
History
Contributors
Metrics & Citations
Metrics
Note:
- For recently published articles, the TOTAL download count will appear as zero until a new month starts.
- There is a 3- to 4-day delay in article usage, so article usage will not appear immediately after publication.
- Citation counts come from the Crossref Cited by service.
Citations
If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. For an editable text file, please select Medlars format which will download as a .txt file. Simply select your manager software from the list below and click Download.