Analysis of Sequence Conservation at Nucleotide Resolution
Figure 1
Examples of SCONE p-Value Scores for Coding (A), Highly Conserved Noncoding (B), and Nonconserved Regions
Positions likely to be conserved (p < 0.05) are in light green; other positions are dark. Below each plot is the portion of the multiple sequence used to generate scores for each sequence region. Deviations from human sequence (green) are indicated in red.
(A) A portion of an exon from the MET gene (chr7:115,933,744–115,933,793). The pattern of conserved positions is indicative of the triplet structure of the genetic code.
(B) A highly conserved intronic sequence in the FOXP2 gene (chr7:113,646,877–113,646,926).
(C) An intergenic region near the AXIN1 gene (chr16:343,046–343,095) showing little overall conservation, but containing a significant number of individually conserved positions.