Chapter title |
Allotypes of IgM and IgD receptors in the mouse: a probe for lymphocyte differentiation.
|
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Chapter number | 7 |
Book title |
Contemporary Topics in Immunobiology
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Published in |
Contemporary topics in immunobiology, January 1978
|
DOI | 10.1007/978-1-4684-0922-2_7 |
Pubmed ID | |
Book ISBNs |
978-1-4684-0924-6, 978-1-4684-0922-2
|
Authors |
James W. Goding, Goding, James W. |
Abstract |
Antibodies to IgD and IgM are present in many mouse alloantisera made against lymphocytes. Antibodies to IgM are also present in a small minority of conventional antiallotype sera made against pertussis/anti-pertussis complexes. These antibodies reflect different allelic forms of IgD and IgM in different mouse strains, and allowed the mapping of the delta- and mu-chain genes (Ig-5 and Ig-6, respectively) to the heavy-chain complex. The variable portions of IgM and IgD receptors on individual cells bearing both chains are similar or identical. Both receptors show allelic exclusion and come from the same chromosome on individual cells (haplotype exclusion). It is suggested that very early in B lymphocyte differentiation there is a commitment to a given chromosome, and translocation of one copy of a given variable region gene to each heavy-chain gene. Subsequent switches of immunoglobulin class then involve differential gene activation. Immature B cells possess IgM receptors only and mature into cells bearing both IgM and IgD receptors. After activation with antigen, IgD is probably lost. These findings are discussed within the framework of the clonal abortion theory of B-lymphocyte tolerance. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 6 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 2 | 33% |
Student > Bachelor | 2 | 33% |
Unspecified | 1 | 17% |
Researcher | 1 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 2 | 33% |
Unspecified | 1 | 17% |
Materials Science | 1 | 17% |
Engineering | 1 | 17% |
Unknown | 1 | 17% |