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Contemporary Topics in Immunobiology

Overview of attention for book
Attention for Chapter 7: Allotypes of IgM and IgD receptors in the mouse: a probe for lymphocyte differentiation.
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8 Wikipedia pages

Citations

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33 Dimensions

Readers on

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6 Mendeley
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Chapter title
Allotypes of IgM and IgD receptors in the mouse: a probe for lymphocyte differentiation.
Chapter number 7
Book title
Contemporary Topics in Immunobiology
Published in
Contemporary topics in immunobiology, January 1978
DOI 10.1007/978-1-4684-0922-2_7
Pubmed ID
Book ISBNs
978-1-4684-0924-6, 978-1-4684-0922-2
Authors

James W. Goding, Goding, James W.

Abstract

Antibodies to IgD and IgM are present in many mouse alloantisera made against lymphocytes. Antibodies to IgM are also present in a small minority of conventional antiallotype sera made against pertussis/anti-pertussis complexes. These antibodies reflect different allelic forms of IgD and IgM in different mouse strains, and allowed the mapping of the delta- and mu-chain genes (Ig-5 and Ig-6, respectively) to the heavy-chain complex. The variable portions of IgM and IgD receptors on individual cells bearing both chains are similar or identical. Both receptors show allelic exclusion and come from the same chromosome on individual cells (haplotype exclusion). It is suggested that very early in B lymphocyte differentiation there is a commitment to a given chromosome, and translocation of one copy of a given variable region gene to each heavy-chain gene. Subsequent switches of immunoglobulin class then involve differential gene activation. Immature B cells possess IgM receptors only and mature into cells bearing both IgM and IgD receptors. After activation with antigen, IgD is probably lost. These findings are discussed within the framework of the clonal abortion theory of B-lymphocyte tolerance.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 33%
Student > Bachelor 2 33%
Unspecified 1 17%
Researcher 1 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 33%
Unspecified 1 17%
Materials Science 1 17%
Engineering 1 17%
Unknown 1 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 December 2020.
All research outputs
#7,459,696
of 22,807,037 outputs
Outputs from Contemporary topics in immunobiology
#1
of 2 outputs
Outputs of similar age
#4,013
of 25,077 outputs
Outputs of similar age from Contemporary topics in immunobiology
#1
of 1 outputs
Altmetric has tracked 22,807,037 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2 research outputs from this source. They receive a mean Attention Score of 1.6. This one scored the same or higher as 1 of them.
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We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them