Abstract
Direct electron detectors have played a key role in the recent increase in the power of single-particle electron cryomicroscopy (cryoEM). In this chapter, we summarize the background to these recent developments, give a practical guide to their optimal use, and discuss future directions.
Keywords: CMOS; DDD; DQE; Direct Electron; Electron microscopy; FEI; Gatan; MTF; Sensor; cryoEM.
© 2016 Elsevier Inc. All rights reserved.
Publication types
- Historical Article
- Review
MeSH terms
- Bacterial Proteins / ultrastructure
- Biosensing Techniques / history
- Biosensing Techniques / instrumentation
- Biosensing Techniques / methods*
- Cryoelectron Microscopy / history
- Cryoelectron Microscopy / instrumentation
- Cryoelectron Microscopy / methods*
- Electrons*
- Escherichia coli / chemistry
- Escherichia coli / enzymology
- History, 20th Century
- History, 21st Century
- Monte Carlo Method
- Silicon / chemistry
- Software*
- beta-Galactosidase / ultrastructure
Substances
- Bacterial Proteins
- beta-Galactosidase
- Silicon