Impaired Breakdown of Bradykinin and Its Metabolites as a Possible Cause for Pulmonary Edema in COVID-19 Infection

Semin Thromb Hemost. 2020 Oct;46(7):835-837. doi: 10.1055/s-0040-1712960. Epub 2020 Jun 11.

Authors

Steven de Maat¹, Quirijn de Mast², A H Jan Danser³, Frank L van de Veerdonk², Coen Maas¹

Affiliations

¹ CDL Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
² Department of Internal Medicine, Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
³ Department of Internal Medicine, Division of Pharmacology and Vascular Medicine, Erasmus MC, Rotterdam, The Netherlands.

No abstract available

Publication types

Review

MeSH terms

Angiotensin II / physiology
Angiotensin-Converting Enzyme 2
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Animals
Betacoronavirus*
Bradykinin / analogs & derivatives
Bradykinin / metabolism*
COVID-19
Chick Embryo
Coronavirus Infections / complications*
Coronavirus Infections / metabolism
Disease Models, Animal
Humans
Kininogens / metabolism
Mice
Pandemics*
Peptidyl-Dipeptidase A / metabolism
Pneumonia, Viral / complications*
Pneumonia, Viral / metabolism
Pulmonary Edema / etiology*
Renin-Angiotensin System / physiology
SARS-CoV-2

Substances

Angiotensin-Converting Enzyme Inhibitors
KNG1 protein, human
Kininogens
Angiotensin II
bradykinin, des-Arg(9)-
Peptidyl-Dipeptidase A
ACE2 protein, human
Ace2 protein, mouse
Angiotensin-Converting Enzyme 2
Bradykinin