Trans-splicing and polycistronic transcription in Caenorhabditis elegans

Trends Genet. 1995 Apr;11(4):132-6. doi: 10.1016/s0168-9525(00)89026-5.

Abstract

Caenorhabditis elegans engages in three distinct versions of nuclear pre-mRNA splicing: cis-splicing of introns and two kinds of trans-splicing that result in the addition of two different spliced leaders onto mRNAs. One leader (SL1) is used near the 5' ends of pre-mRNAs while the other (SL2) is used at internal trans-splice sites of polycistronic pre-mRNAs. Here, I consider how these three types of splicing event are faithfully carried out.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Evolution
  • Caenorhabditis elegans / genetics*
  • Genes
  • Operon
  • RNA Splicing*
  • Transcription, Genetic*