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Biomechanical Design of Elastic Protein Biomaterials: A Balance of Protein Structure and Conformational Disorder

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† Molecular Structure and Function Program, Research Institute, The Hospital for Sick Children, 686 Bay Street, Toronto, Ontario, Canada M5G 0A4
‡ Department of Biochemistry and Department of Laboratory Medicine and Pathobiology, 1 King’s College Circle, University of Toronto, Toronto, Ontario, Canada M5S 1A8
*E-mail: [email protected]
Cite this: ACS Biomater. Sci. Eng. 2017, 3, 5, 661–679
Publication Date (Web):October 10, 2016
https://doi.org/10.1021/acsbiomaterials.6b00469
Copyright © 2016 American Chemical Society
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    Elastic biomaterials are found across biology where they fulfill diverse load-bearing and energy storage and dissipation functions. This class of biomaterials comprises elastic proteins that provide materials with combinations of extensibility, stiffness, tensile strength, toughness, and viscoelastic properties. Differences in mechanical properties are due in large part to variations in the ratio of secondary structure and conformational disorder of constituent protein monomers, arising from differences in amino acid sequence. This natural diversity provides rich inspiration for the design of elastic biomaterials. Here, we review the relationship between sequence, structure, disorder, and mechanical properties of elastic proteins from natural materials ranging from highly extensible and soft, to mechanically strong and tough. We describe molecular strategies as well as recombinant efforts to design materials with tailored mechanical properties, with the ultimate aim of rationally engineering biomaterials for advanced biomedical applications.

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