Cancer Viruses and Viral Cancers

25 July 2023
25 July 2023
Special Issue Editor: Dr. Deilson Elgui De Oliveira

Table of Contents

Open Access

Epstein−Barr virus reactivation induces MYC-IGH spatial proximity and t(8;14) in B cells

Statement of significance

This study analyzed the role of Epstein−Barr virus (EBV) reactivation in the occurrence of Burkitt lymphoma-specific t(8;14) chromosomal translocations. Our findings demonstrate that EBV reactivation induces MRE11-dependent proximity between the MYC and IGH loci in B cells, which translates into elevated t(8;14) rates upon induction of DSBs within these loci.