Differential SERM Effects on Corepressor Binding Dictate ERα Activity In Vivo

Journal of Biological Chemistry, 2003

Abstract

Selective estrogen receptor modulators (SERMs) show differential effects upon ERα activation function 1 (AF-1). Tamoxifen allows strong ERα AF-1 activity, whereas raloxifene allows less and ICI 182,780 (ICI) allows none. Here, we show that blockade of corepressor histone ...

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Differential SERM Effects on Corepressor Binding Dictate ERα Activity In Vivo

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