Histone deacetylases
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Recent papers in Histone deacetylases
Heterochromatin in metazoans induces transcriptional silencing, as exemplified by position effect variegation in Drosophila melanogaster and X-chromosome inactivation in mammals. Heterochromatic DNA is packaged in nucleosomes that are... more
Summary Primary cilia, which emanate from the cell surface, exhibit assembly and disassembly dynamics along the progression of cell cycle. However, the mechanism that links ciliary dynamics and cell cycle regulation remains elusive. Here,... more
Novel macrocyclic peptide mimetics have been synthesized by exploiting a three-component reaction and an azide–alkyne [3 + 2] cycloaddition. The prepared compounds were screened as HDAC inhibitors allowing us to identify a new compound... more
Silent information regulator two proteins (sirtuins or SIRTs) are a group of histone deacetylases whose activities are dependent on and regulated by nicotinamide adenine dinucleotide (NAD+). They suppress genome-wide transcription, yet... more
NMR-based metabolic profiling was used to assess the effect of Trichostatin A (TSA) treatment on the endogenous metabolome of cultured primary hepatocytes. TSA-treated cultures were metabolically distinct from nontreated cells and the... more
Cellular activation, proliferation and survival in chronic inflammatory diseases is regulated not only by engagement of signal trans-duction pathways that modulate transcription factors required for these processes, but also by epigenetic... more
Activation of complement stimulates inflammation and provides an initial vigorous defense against infection. Insertion of the membrane attack complex in cell membranes of vascular endothelial cells induces changes in cell differentiation... more