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7 result(s) for 'author#Jean-Pierre Vartanian' within BMC
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Citation: Retrovirology 2016 13:52
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Human APOBEC1 cytidine deaminase edits HBV DNA
Retroviruses, hepadnaviruses, and some other retroelements are vulnerable to editing by single stranded DNA cytidine deaminases. Of the eleven human genes encoding such enzymes, eight have demonstrable enzymat...
Citation: Retrovirology 2009 6:96 -
PCR mediated recombination impacts the analysis of hepatitis B Virus covalently closed circular DNA
The replication of HBV involves the production of covalently closed circular DNA (cccDNA) from the HBV genome through the repair of virion relaxed circular DNA (rcDNA) in the virion. As cccDNA is the transcrip...
Citation: Retrovirology 2016 13:84 -
ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity
The role of innate immunity in general and of type I interferon (IFN-I) in particular in HTLV-1 pathogenesis is still a matter of debate. ADAR1-p150 is an Interferon Stimulated Gene (ISG) induced by IFN-I that...
Citation: Retrovirology 2014 11:93 -
New insights into the heterogeneity of Th17 subsets contributing to HIV-1 persistence during antiretroviral therapy
Th17 cells are permissive to HIV-1 infection and their depletion from the gut of infected individuals leads to microbial translocation, a major cause for non-AIDS co-morbidities. Most recent evidence supports ...
Citation: Retrovirology 2016 13:59 -
Critical contribution of mitochondria in the development of cardiomyopathy linked to desmin mutation
Beyond the observed alterations in cellular structure and mitochondria, the mechanisms linking rare genetic mutations to the development of heart failure in patients affected by desmin mutations remain unclear...
Citation: Stem Cell Research & Therapy 2024 15:10 -
Mouse APOBEC1 cytidine deaminase can induce somatic mutations in chromosomal DNA
APOBEC1 (A1) enzymes are cytidine deaminases involved in RNA editing. In addition to this activity, a few A1 enzymes have been shown to be active on single stranded DNA. As two human ssDNA cytidine deaminases ...
Citation: BMC Genomics 2019 20:858