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895 result(s) for 'author#Nick Lane' within BMC

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  2. The palindromic termini of parvoviruses have proven to play an essential role as origins of replication at different stages during the replication of their viral genome. Sequences from the left-end telomere of...

    Authors: Nanette Diffoot-Carlo, Lisandra Vélez-Pérez and Idaris de Jesús-Maldonado
    Citation: Virology Journal 2005 2:47
    Content type: Research Published on:

  3. Conjugative spread of antibiotic resistance and virulence genes in bacteria constitutes an important threat to public health. Beyond the well-known conjugative plasmids, recent genome analyses have shown that ...

    Authors: Nicolas Soler, Emilie Robert, Isaure Chauvot de Beauchêne, Philippe Monteiro, Virginie Libante, Bernard Maigret, Johan Staub, David W. Ritchie, Gérard Guédon, Sophie Payot, Marie-Dominique Devignes and Nathalie Leblond-Bourget
    Citation: Mobile DNA 2019 10:18
    Content type: Research Published on:

  4. The current investigation was undertaken to determine key steps differentiating G:T and G:A repair at the H-ras oncogenic hot spot within the nuclear environment because of the large difference in repair efficien...

    Authors: Michael Edelbrock, Huiling He, Allen Schroering, Martha Fernstrom, Sangeetha Bathala and Kandace J Williams
    Citation: BMC Molecular Biology 2005 6:6
    Content type: Research article Published on:

  5. Suppression of gene expression by small interfering RNA (siRNA) has proved to be a gene-specific and cost effective alternative to other gene suppression technologies. Short hairpin RNAs (shRNAs) generated fro...

    Authors: Hailong Wu, Anh Dinh and Yin-Yuan Mo
    Citation: Biological Procedures Online 2007 9:91009
    Content type: OriginalPaper Published on:

  6. Pseudomonas aeruginosa encodes a putative topoisomerase with sequence similarity to the eukaryotic type IB topoisomerase from Vaccinia virus. Residues in the active site are conserved, notably Tyr292 which would ...

    Authors: Teesta Jain, Benjamin J Roper and Anne Grove
    Citation: BMC Molecular Biology 2009 10:23
    Content type: Research article Published on:

  7. Functional immunoglobulin and T cell receptor genes are produced in developing lymphocytes by V(D)J recombination. The initial site-specific DNA cleavage steps in this process are catalyzed by the V(D)J recomb...

    Authors: Pallabi De, Shuying Zhao, Lori M Gwyn, LeAnn J Godderz, Mandy M Peak and Karla K Rodgers
    Citation: BMC Biochemistry 2008 9:5
    Content type: Research article Published on:

  8. During DNA replication or repair, disease-associated (CAG)n/(CTG)n expansion can result from formation of hairpin structures in the repeat tract of the newly synthesized or nicked DNA strand. Recent studies ident...

    Authors: Caixia Hou, Tianyi Zhang, Lei Tian, Jian Huang, Liya Gu and Guo-Min Li
    Citation: Cell & Bioscience 2011 1:11
    Content type: Research Published on:

  9. The quality of chemically synthesized oligonucleotides falls with the length of the oligonucleotide, not least due to depurinations and premature termination during production. This limits the use of long olig...

    Authors: Jakob S Lohmann, Magnus Stougaard and Jørn Koch
    Citation: BMC Biotechnology 2007 7:49
    Content type: Methodology article Published on:

  10. The putative regulatory role of the male reproductive hormones in the molecular mechanism underlying chromatin condensation remains poorly understood. In the past decade, we developed two adult male rat models...

    Authors: Manjeet Kaur Gill-Sharma, Jyoti Choudhuri, Mukhtar Aleem Ansari and Serena D’Souza
    Citation: Clinical Epigenetics 2012 4:23
    Content type: Research Published on:

  12. DNA ligases are required for DNA strand joining in all forms of cellular life. NAD+-dependent DNA ligases are found primarily in eubacteria but also in some eukaryotic viruses, bacteriophage and archaea. Among th...

    Authors: Laetitia Poidevin and Stuart A MacNeill
    Citation: BMC Molecular Biology 2006 7:44
    Content type: Research article Published on:

  13. Genomics and metagenomics are currently leading research areas, with DNA sequences accumulating at an exponential rate. Although enormous advances in DNA sequencing technologies are taking place, progress is f...

    Authors: Agnieszka Zylicz-Stachula, Olga Zolnierkiewicz, Jacek Jasiecki and Piotr M Skowron
    Citation: BMC Genomics 2013 14:370
    Content type: Methodology article Published on:

  14. A wide variety of DNA lesions interfere with replication and transcription, leading to mutations and cell death. DNA repair mechanisms act upon these DNA lesions present in the genomic DNA. To investigate a DN...

    Authors: Mika Yukutake, Mika Hayashida, Narumi Shioi Aoki and Isao Kuraoka
    Citation: Genes and Environment 2018 40:23
    Content type: Research Published on:

  15. DNA-protein cross-links (DPCs) are one of the most deleterious DNA lesions, originating from various sources, including enzymatic activity. For instance, topoisomerases, which play a fundamental role in DNA me...

    Authors: Victoria Marini, Fedor Nikulenkov, Pounami Samadder, Sissel Juul, Birgitta R. Knudsen and Lumir Krejci
    Citation: BMC Biology 2023 21:110
    Content type: Research article Published on:

  16. Engineered endonucleases are a powerful tool for editing DNA. However, sequence preferences may limit their application. We engineer a structure-guided endonuclease (SGN) composed of flap endonuclease-1 (FEN-1...

    Authors: Shu Xu, Shasha Cao, Bingjie Zou, Yunyun Yue, Chun Gu, Xin Chen, Pei Wang, Xiaohua Dong, Zheng Xiang, Kai Li, Minsheng Zhu, Qingshun Zhao and Guohua Zhou
    Citation: Genome Biology 2016 17:186
    Content type: Method Published on:

  17. Escherichia coli RecA plays a crucial role in recombinational processes, the induction of SOS responses and mutagenic lesion bypasses. It has also been demonstrated that RecA protein is indispensable when it come...

    Authors: Marta Wanarska, Beata Krawczyk, Piotr Hildebrandt and Józef Kur
    Citation: BMC Molecular Biology 2011 12:17
    Content type: Research article Published on: